Clinical characteristics of keratoconus patients in Malaysia: a review from a cornea specialist centre

Mohd‐Ali, Bariah; Abdu, Mustafa; Yaw, Choong Yean; Mohidin, Norhani

doi:10.1016/j.optom.2012.01.002

Cited by 25 publications

(32 citation statements)

References 14 publications

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“…This study found a mean age at the time of diagnosis of around 23.33 ± 7.37 years, and no significant difference was found in the mean age between sexes ( P = 0.548). Our result was nearly consistent with a Malaysian study, where the mean age of disease onset was 20.9 ± 5.6 years [ 15 ]. Meanwhile, in Saudi Arabia, the mean age at diagnosis was slightly lower than in our study, about 17.7 years for males and 19.0 years for females [ 16 ].…”

Section: Discussionsupporting

confidence: 92%

“…Most of the patients in this study, as well as those in the Saudi Arabian [ 16 ], Malaysian [ 15 ] and Macedonian [ 17 ] studies presented with the mild disease form at the time of diagnosis, for example, in this study, 62% had the mild form, 28.1% had moderate KC and 9.9% of the total patients’ eyes had severe KC. Moreover, in Malaysia 37.6%, were stage I, 30.1% stage II, 4.4% stage III and 27.8% stage IV at the time of diagnosis [ 15 ]. Also, in Saudi Arabia it was found that 39.2% were in the early stage, 42.5% in the moderate stage and 18.3% in the advanced one [ 16 ].…”

Section: Discussionmentioning

confidence: 66%

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Characteristics of keratoconic patients at two main eye centres in Palestine: a cross-sectional study

et al. 2018

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BackgroundKeratoconus (KC) is a multifactorial, degenerative ectatic condition of the cornea. It usually manifests during late adolescence or the early twenties. A painless disease, KC may end with severe visual loss. The prevalence of KC in middle-eastern countries is much higher than in other regions of the world. This may be due to genetic and environmental risk factors and consanguinity. The goal of this study is to explore the demographic profile of Palestinian keratoconic patients.MethodsA retrospective study was conducted in two ophthalmology centres (Tertiary Ophthalmic Centre of An-Najah National University Hospital and An-Noor Centre at the Specialized Arab Hospital). All medical charts of keratoconic patients attending both centres over the period from 2009 to 2016 were reviewed. These patients were diagnosed by ophthalmologists depending on history, examination and Pentacam. Severity was determined using the k median index from the Pentacam map. Data analysis was carried out using SPSS Version 22.ResultsThe medical files of 936 keratoconic eyes of 505 keratoconic patients were reviewed. Their mean age at the time of diagnosis was 23.3 ranging from 8 to 62 years. Approximately 70.1% of them presented after the age of 20 years, and younger age groups were more likely to develop a severe disease stage than older ones (P = 0.001, r = − 0.108). There was a nearly equal distribution of patients between the two sexes (49.5% male, 50.5% female). On initial evaluation, the best-corrected visual acuity (BCVA) was recorded as ≥6/12 in most affected eyes (71.5%). Regarding severity, 62% presented in a mild form, while 9.9% were at a severe stage. About 88.2% presented with bilateralism.ConclusionsMost of the patients in their twenties presented with a mild bilateral form of the disease. This result is compatible with published international reports. It is recommended that the results of this study be considered when establishing a screening program in Palestine. Subsequently, patients will be identified at an appropriate time where action can be taken before disease progression take place.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 66%

Characteristics of keratoconic patients at two main eye centres in Palestine: a cross-sectional study

et al. 2018

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“…Similar results were observed in other researches as one done in Kenya by Zahra Aly Rashid, et al mentioned that severe keratoconus in (71%) followed by moderate in (22.9%) and mild keratoconus in (6.2%) [43]. Tarannum Fatima, et al found that severe keratoconus in (49%) of cases and (36.7%) were moderate [44], while in other studies they found that moderate keratoconus was more frequent like study done in Iran by Naderan M, Shoar S, et al in which they found that moderate keratoconus was (43.8%) while the severe keratoconus (41%) [45]. Bilgin In our study there is no significant difference in grades of keratoconus between genders (p value= 0.087).…”

Section: Discussionsupporting

confidence: 85%

Prevalence of Refractive Errors in Patients with Keratoconus among Sample of Iraqi Population

Kf¹

2017

OAJO

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Background: Kerato-conus is a progressive disease of the cornea with deformed keratometry readings, characterize by progressive thinning of corneal apex and corneal ectasia. Keratoconus can affect each layer of the cornea. Keratoconus present in patients with teenage groups and early twenties with complaints of deterioration of vision and frequent change of glasses due to alteration in refractive state of them who develops different types of astigmatism, commonly myopic one. Aim of Study: The prevalence of refractive errors in patients with keratoconus to explain their clinical characteristics. Patients & Methods: This is a retrospective cross sectional research study, in which the clinical data in recorded files were reviewed, (343) eyes of (180) patients with keratoconus, among them (110) were females and (70) were males consulting Al-Najaf refractive surgery center and Al-Hakeem general hospital for correction of their refractive errors during the period between May, 2016 through February, 2017. Results: The commonest refractive error that present in all grades and age groups of the disease is compound myopic astigmatism (69.7%) followed by simple myopic astigmatism (25.4%), mixed astigmatism (3.2%) then the simple myopia (1.7%). Conclusion: The prevalence of keratoconus was higher among patients between (10 to 30) years old. Females were the dominant gender but no significant difference detected in grades of keratoconus and refractive error between genders.

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“…The study showed that prevalence of keratoconus significantly increased with age [ 17 ]. Another study conducted in Malaysia reported that 26.4% of KC patients were under 23 years of age, while 52.8% were in between 23 and 32 years of age [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Keratoconus Among a Palestinian Tertiary Student Population

Shehadeh¹,

Diakonis²,

Jalil³

et al. 2015

TOOPHTJ

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Purpose:To screen for keratoconus and potential associated risk factors in a tertiary student population sample.Population and Methods:This cross sectional study included 1234 students attending An-Najah National University (Nablus, West Bank, Palestine), that were randomly selected from a total of 20,000 university students. 634 (51.3%) student participants responded by completing a self-administered questionnaire and were assessed by means of corneal topography. Following initial evaluation, participants were referred for Pentacam evaluation if they demonstrated either a mean keratometry of more than 45 diopters, corneal astigmatism of more than 2 diopters and/or if asymmetric topographic patterns were present. Pentacam images were analyzed by an experienced ophthalmologist based on a number of indices and the participants were classified as normal, keratoconus suspects, and keratoconus patients.Results:A total of 620 participants (mean age, 20.1±1.6 years) were included in this study, 379 (61.1%) were females and 241 (38.9%) were males. Nine subjects were diagnosed with keratoconus, demonstrating a prevalence of 1.5%. 52 (8.4%) participants showed at least one abnormal pentacam index, and were considered as KC suspects.Conclusion:Keratoconus is a prevalent disease among the tertiary Palestinian student population. This may be related to a combination of genetic and environmental factors. The results of this study signal the need for public health outreach and intervention for keratoconus.

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Clinical characteristics of keratoconus patients in Malaysia: a review from a cornea specialist centre

Cited by 25 publications

References 14 publications

Characteristics of keratoconic patients at two main eye centres in Palestine: a cross-sectional study

Characteristics of keratoconic patients at two main eye centres in Palestine: a cross-sectional study

Prevalence of Refractive Errors in Patients with Keratoconus among Sample of Iraqi Population

Prevalence of Keratoconus Among a Palestinian Tertiary Student Population

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