Clinical characteristics of malignant melanoma in central China and predictors of metastasis

Shi, Ke; Zhu, Xuran; Liu, Zhongyang; Sun, Nan; Gu, Luosha; Wei, Yang; Xu, Cheng; Zhang, Zewei; Xie, Baihui; Yang, Shenghong; Li, Guangshuai; Linbo, Liu

doi:10.3892/ol.2019.11219

Cited by 8 publications

(8 citation statements)

References 55 publications

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“…To obtain the hub genes of BSG in TC, we first searched the cBioPortal for Cancer Genomics [ 32 ] and found the co-expressed genes of BSG. The DEGs from all gene microarray datasets and RNA-seq data were obtained using the RRA method.…”

Section: Methodsmentioning

confidence: 99%

“…The potential mechanism of BSG expression in thyroid cancer Identification of BSG co-expressed genes and differentially expressed genes (DEGs) in TC To obtain the hub genes of BSG in TC, we first searched the cBioPortal for Cancer Genomics [32] and found the co-expressed genes of BSG. The DEGs from all gene microarray datasets and RNA-seq data were obtained using the RRA method.…”

Section: Validation Of the Expression Of Bsg Using Cell Line Data Fromentioning

confidence: 99%

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Immunohistochemical basigin expression level in thyroid cancer tissues

et al. 2020

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Background: Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism. Methods: The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC. Results: The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p < 0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly upregulated in TC cases. Conclusion: BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.

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Section: Methodsmentioning

confidence: 99%

Section: Validation Of the Expression Of Bsg Using Cell Line Data Fromentioning

confidence: 99%

Immunohistochemical basigin expression level in thyroid cancer tissues

et al. 2020

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show abstract

“…The coloured bars represent mean and standard deviations obtained from literature studies. [30][31][32][33][34][35][36][37][38][39] For albumin and AAG, a second population was simulated with a 50% reduction in% CV.…”

Section: The Impact Of Drug-drug Interactions On Gefitinib Pharmacoki...mentioning

confidence: 99%

The Pharmacokinetics of Gefitinib in a Chinese Cancer Population Group: A Virtual Clinical Trials Population Study

He¹,

Badhan²

2021

Journal of Pharmaceutical Sciences

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“…To obtain the hub genes of BSG in TC, we rst searched the cBioPortal for Cancer Genomics [32]and found the co-expressed genes of BSG. The DEGs from all gene microarray datasets and RNA-seq data were obtained using the RRA method.…”

Section: The Potential Mechanism Of Bsg Expression In Thyroid Cancer mentioning

confidence: 99%

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

Guo

Tang

Pang

et al. 2020

Preprint

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Background: Thyroid cancer (TC) is the most common endocrine malignancy, Basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism. Methods: The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC. Results: The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p<0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly up-regulated in TC cases. Conclusion: BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.

show abstract

Clinical characteristics of malignant melanoma in central China and predictors of metastasis

Cited by 8 publications

References 55 publications

Immunohistochemical basigin expression level in thyroid cancer tissues

Immunohistochemical basigin expression level in thyroid cancer tissues

The Pharmacokinetics of Gefitinib in a Chinese Cancer Population Group: A Virtual Clinical Trials Population Study

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

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