Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings

Sun, Qiao; Sun, Mingming; Zhang, Yuan; Wang, Song; Bai, Wenhao; Wei, Shimin; Xu, Quangang; Zhou, Huanfen

doi:10.1155/2022/4671671

Cited by 7 publications

(2 citation statements)

References 37 publications

(55 reference statements)

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“…[ 6 ] Additionally, a mitochondrial genetic defect as a predisposing factor has been suggested by Sun et al . [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome

Gheshlaghi,

Wong,

Firuzfar

et al. 2023

Journal of Research in Pharmacy Practice

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Objective: Methanol poisoning can occur either intentionally through the consumption of methanol-containing products or accidentally through ingestion, resulting in visual impairment. We assessed the long-term visual sequelae in patients with methanol poisoning. Methods: This prospective cohort study was conducted at referral centers, Khorshid and Alzahra University Hospitals, affiliated with Isfahan University of Medical Sciences, Isfahan, Iran. The study included patients hospitalized for methanol poisoning from June 22, 2018, to June 21, 2020, with follow-up extended until June 2021. Toxico-clinical and ophthalmologic examination data were collected from patients upon hospital admission, discharge, and during follow-up. Findings: Thirty-nine patients were assessed in this study. The majority of them (94.9%) were male, with an average age of 34 years. Patients who presented with reduced visual acuity (VA) upon admission subsequently showed abnormalities (in acuity and visual fields) during follow-up (n = 13). Among the patients who displayed visual field defects on admission, bilateral optic disc atrophy was observed in follow-up (n = 13). Conversely, patients who reported blurred vision, with or without photophobia upon admission, had normal results in their follow-up eye examinations. Among the 36 patients who underwent dialysis, 14 (38.9%) exhibited visual impairment during follow-up examinations. Additionally, 38 patients received sodium bicarbonate, and 14 of them (36.85%) also presented ocular abnormalities. Conclusion: Patients who demonstrated VA deficits upon admission are more likely to experience long-term VA and visual field defects, as well as optic disc atrophy. Patients who solely complained of blurred vision, with or without photophobia, during admission were less likely to develop long-term visual defects.

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“…[ 6 ] Additionally, a mitochondrial genetic defect as a predisposing factor has been suggested by Sun et al . [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome

Gheshlaghi,

Wong,

Firuzfar

et al. 2023

Journal of Research in Pharmacy Practice

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“…Some studies have reported that magnetic resonance imaging abnormalities, like T1 enhancement and or long T2 in the retrobulbar segment of optic nerves, were found in methanol-induced optic neuropathy. Optical coherence tomography finding of ganglion cell layer loss, selectively involving the papillomacular bundle, was also reported [4]. Ma et al also mentioned that inhalational methanol toxicity may lead to serious damage to the optic nerve in a process of chronic intoxication with acute attack and poor prognosis [5].…”

Section: Introductionmentioning

confidence: 92%

Evaluation of the Efficacy of Melatonin in Visual Disturbed Methanol-intoxicated Patients: A Randomized Clinical Trial

Samsamshariat,

Zoofaghari,

Meamar

et al. 2024

IJMTFM

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Background: This study evaluates the role of oral melatonin in improving vision in methanol toxicity since vision disorders are one of the side effects related to methanol toxicity and assumes the potential effects of melatonin in protecting neurons and optic nerves. Meanwhile, little attention has been paid by researchers to the effect of melatonin in these patients. Methods: A double-blind randomized controlled clinical trial study was conducted on 40 patients diagnosed with methanol toxicity who were referred to Khorshid Hospital of Isfahan City, Iran, from May 2022 to May 2023. These patients were randomly divided into two groups. In the first group (the intervention group), in addition to the usual treatment, the patients were prescribed orally 3 mg of melatonin every morning and 6 mg of melatonin every night for 10 days. In the second group (the control group), in addition to the usual treatment, a placebo was administered similar to the intervention group protocol. Then, the clinical and vision parameters of the patients were evaluated before, during, and after the intervention. Results: The mean pH, PCO2 and HCO3 increased significantly after the intervention compared to the pre-intervention in both groups (P<0.05); however, no significant difference was found between the two groups in any of the two follow-up times (P>0.05). The most common visual complication caused by methadone toxicity was blurred vision with 71.4% and 90% in the melatonin and non-melatonin groups, respectively. Visual complications improved significantly after the intervention compared to the pre-intervention; accordingly, the complete improvement of vision complications in the melatonin group (76.2%) was significantly more than the non-melatonin group (53.3%) (P=0.040). Conclusion: Melatonin improves blurred or snowfield vision in methanol poisoning. Therefore, the administration of melatonin plus routine treatment can be effective in improving vision disorders (blurred or snowfield vision) caused by methanol poisoning.

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Maculopapillary Bundle Degeneration in Optic Neuropathies

Lambiri,

Levin

2024

Curr Neurol Neurosci Rep

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Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings

Cited by 7 publications

References 37 publications

Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome

Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome

Evaluation of the Efficacy of Melatonin in Visual Disturbed Methanol-intoxicated Patients: A Randomized Clinical Trial

Maculopapillary Bundle Degeneration in Optic Neuropathies

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