Clinical Characteristics of Optic Neuritis in Koreans Greater than 50 Years of Age

Choi, Jin Seok; Kim, Seong Joon; Chang, Ji Woong; Kim, Jeong Hun; Yu, Young Suk

doi:10.3341/kjo.2012.26.2.111

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…A recent study, which is conducted in Korea, reported that patients > 50 years recovered well from ON attacks; all affected eyes had final BCVA > 20/40 within two months [ 15 ]. However, the small sample size, eight patients in total, may result in increase of the bias.…”

Section: Discussionmentioning

confidence: 99%

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Wang

Zhou

Qin

et al. 2017

Journal of Ophthalmology

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Objective This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45–65 years and age ≥ 65 years). Results 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45–83 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA) < 20/200 in 93% and final BCVA < 20/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (≥65 years) developed NMOSD or MS. Conclusion Chinese patients in the age group ≥ 65 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery.

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Section: Discussionmentioning

confidence: 99%

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Wang

Zhou

Qin

et al. 2017

Journal of Ophthalmology

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“…NAION is a sight threatening disease that typically presents a painless and prompt loss of vision in the middleaged or elderly, which is associated to campimetric defects, being the most common type an inferior altitudinal defect, although other types may also be present, such as arcuate scotoma, central scotoma, blind-spot enlargement, and ring scotoma (Choi et al 2012;Hayreh and Zimmerman 2005). Depending on the severity of the NAION, some patients may experience a worsening, stabilisation, or improvement of their visual function, though, in general terms, NAION is associated to a poor prognosis due to the irreversible changes of the optic disc derived from temporally insufficient blood supply (Jung et al 2011).…”

Section: Introductionmentioning

confidence: 98%

Metabolomics in non-arteritic anterior ischemic optic neuropathy patients by liquid chromatography–quadrupole time-of-flight mass spectrometry

et al. 2014

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Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) is a rare ischemic disease that affects the optic nerve. Pathophysiology and mechanism of ischemia of NAION remain uncertain, so the aim of this work is to establish the first metabolic fingerprinting of patients with NAION to discover possible new biomarkers. Twenty-four patients, aged 39-85 years, diagnosed with NAION, after a sudden loss of vision, were recruited for the study. Plasma samples of patients and controls were fingerprinted with liquid chromatography coupled to quadrupole time-offlight by electrospray ionization, and obtained data were filtered, aligned and statistically analysed to identify new biomarkers. The identity of compounds that were found to be significant in class separation was later confirmed by obtaining the characteristic MS/MS spectra and online databases. In general, biochemical and metabolic profiles between patients and controls did not show profound differences, but NAION patients presented disturbances in the phospholipid composition which lead to reduced plasma values of LysoPCs. Altered levels of other metabolites, such as L-Palmitoylcarnitine, have been detected and could be considered as potential biomarkers.

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“…There is a paucity of information describing the clinical profile of ON in middle-aged and elderly populations. To our knowledge, only three articles from China [ 2 , 7 ] and Korea [ 6 ] have described ON profiles in this age group in the Asian region. The ONTT and a few other studies reported female predominance among ON patients [ 2 , 4 , 9 ]; although the background of this observation is unclear, it was believed to be due to the twofold risk of developing a demyelinating disease (MS) in young women [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are limited studies describing ON features in populations older than 45 years of age. This can be due to the rarity of ON, and this is oftentimes misdiagnosed as non-arteritic anterior ischaemic optic neuropathy (NAION) due to the overlapping clinical profiles of these two diseases [ 6 ]. There are also inconsistent findings describing ON in middle-aged and elderly populations in China, Korea, and the US [ 2 , 6 - 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…This can be due to the rarity of ON, and this is oftentimes misdiagnosed as non-arteritic anterior ischaemic optic neuropathy (NAION) due to the overlapping clinical profiles of these two diseases [ 6 ]. There are also inconsistent findings describing ON in middle-aged and elderly populations in China, Korea, and the US [ 2 , 6 - 8 ]. Therefore, to improve the understanding of this disease in our population, we described the clinical manifestations, visual outcomes, and etiology of ON in patients in this age group.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Profile of Optic Neuritis in Malaysian Patients Older Than 45 Years of Age

Hudzaifah-Nordin¹,

Wendy-Ong²,

Nurul-Ain³

et al. 2022

Cureus

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Introduction Optic neuritis (ON) is a blinding inflammatory disease of the optic nerve, typically affecting young adults as described in the Optic Neuritis Treatment Trial (ONTT). However, there is limited information describing ON in patients older than 45 years of age. The aim of this study was to determine the clinical profile of ON in this age group in Malaysia. Methods A retrospective case series study was performed between January 2014 and December 2018 among patients older than 45 years old, treated as ON in Hospital Universiti Sains Malaysia, Kelantan, Malaysia. Clinical features, visual acuity, imaging, laboratory results, aetiologies, and visual outcomes were analyzed. Results This study comprised 17 patients (20 eyes) with a gender distribution of eight males and nine females. The mean age of ON onset was 55.8 ± 7.7 years (46-80 years). Most patients (94.1%) presented with reduced vision and retroorbital pain, and three patients (17.6%) had bilateral eye involvement. Papillitis was observed in 13 eyes (65%), retrobulbar ON in five eyes (25%), and optic atrophy in two eyes. Presenting visual acuity was moderately correlated with final visual outcome (rs= 0.47, n = 20, p < 0.05). Post-treatment visual improvement (good and slight) was reported in 14 eyes (70%), four (20%) had no improvement while the remaining two eyes (10%) had worsening best-corrected visual acuity (BCVA). Infective causes accounted for 23.5% of cases (one ocular syphilis, two ocular tuberculosis, and one case of toxoplasmosis). Most cases (70.6%) were idiopathic ON, and only one case was diagnosed with neuromyelitis optica spectrum disorder (NMOSD). Conclusion ON in Malaysian patients older than 45 years of age has no gender predilection and is most likely to be idiopathic; however, infective ON must still be ruled out. Overall visual outcomes were satisfactory. Among the infective causes, ocular tuberculosis caused poor visual recovery as compared with syphilitic and toxoplasmosis-related ON cases.

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Clinical Characteristics of Optic Neuritis in Koreans Greater than 50 Years of Age

Cited by 9 publications

References 17 publications

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Metabolomics in non-arteritic anterior ischemic optic neuropathy patients by liquid chromatography–quadrupole time-of-flight mass spectrometry

Clinical Profile of Optic Neuritis in Malaysian Patients Older Than 45 Years of Age

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