Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort

Feng, Chaoyi; Chen, Qian; Zhao, Guodong; Li, Zhenxin; Chen, Weimin; Sha, Yan; Sun, Xinghuai; Wang, Min; Tian, Guohong

doi:10.1038/s41598-021-93976-1

Cited by 12 publications

(3 citation statements)

References 30 publications

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“…The present study noted a female predominance, particularly in NMOSD and double seronegative optic neuritis, which is in line with the findings of other reports [ 4 , 10 , 29 , 30 ]. Previously, Hussain et al hypothesized that testosterone could stimulate myelin repair [ 31 ].…”

Section: Discussionsupporting

confidence: 93%

A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes

Kemchoknatee

Singhakul

Arjkongharn

et al. 2023

Vision

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The clinical characteristics of three types of optic neuritis (double seronegative optic neuritis; DN-ON, Neuromyelitis optica spectrum disorder-related optic neuritis; NMOSD-ON, and multiple sclerosis-related optic neuritis; MS-ON) were examined in order to identify factors that may affect good visual recovery in Thai patients. The study included patients diagnosed with three types of optic neuritis at Rajavithi Hospital between 2011 and 2020. Visual acuity at the end of 12 months was used as the treatment outcome. Multiple logistic regression analysis was used to evaluate potential predictors of good visual recovery. Of the 76 patients, 61 had optic neuritis, with DN-ON as the most common subtype (52.6%). MS-ON patients were significantly younger (28.3 ± 6.6 years, p = 0.002) and there was a female predominance in all subgroups (p = 0.076). NMOSD-ON patients had a significantly higher proportion of poor baseline VA (p < 0.001). None of the NMOSD-ON patients achieved 0.3 logMAR visual recovery in the 12-month period (p = 0.022). A delay in treatment with intravenous methylprednisolone (IVMP) for more than 7 days increased the risk of failure to gain 0.3 logMAR visual recovery by five times (OR 5.29, 95% CI 1.359–20.616, p = 0.016), with NMOSD-ON as the strongest predictor (OR 10.47, 95% CI; 1.095–99.993, p = 0.041). Early treatment with intravenous methylprednisolone may be important for achieving at least 0.3 logMAR visual recovery in Thai patients with optic neuritis.

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Section: Discussionsupporting

confidence: 93%

A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes

Kemchoknatee

Singhakul

Arjkongharn

et al. 2023

Vision

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“…In a 3-year-follow-up cohort in China, only 25% of the patients with AQP4-ON had a VA ≥20/25, and more than 45% had a VA <20/200, whereas 85% of the patients with MOG-ON had a VA ≥20/25. [ 21 ] Optic disc may be swelling at presentation. The prevalence of disc swelling is higher in MOG-ON than AQP4-ON.…”

Section: Clinical Presentation Of Optic Neuritis In Neuromyelitis Opt...mentioning

confidence: 99%

What's new in neuromyelitis optica spectrum disorder treatment?

Huang

Chu

2022

Taiwan Journal of Ophthalmology

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Optic neuritis, an optic nerve inflammatory disease presenting with acute unilateral or bilateral visual loss, is one of the core symptoms of neuromyelitis optica spectrum disorder (NMOSD). The diagnosis of NMOSD-related optic neuritis is challenging, and it is mainly based on clinical presentation, optical coherence tomography, magnetic resonance imaging scans, and the status of serum aquaporin-4 antibodies. In the pathogenesis, aquaporin-4 antibodies target astrocytes in the optic nerves, spinal cord and some specific regions of the brain eliciting a devastating autoimmune response. Current pharmacological interventions are directed against various steps within the immunological response, notably the terminal complement system, B-cells, and the pro-inflammatory cytokine Interleukin 6 (IL6). Conventional maintenance therapies were off-label uses of the unspecific immunosuppressants azathioprine and mycophenolate mofetil as well as the CD20 specific antibody rituximab and the IL6 receptor specific antibody tocilizumab. Recently, four phase III clinical trials demonstrated the safety and efficacy of the three novel biologics eculizumab, inebilizumab, and satralizumab. These monoclonal antibodies are directed against the complement system, CD19 B-cells and the IL6 receptor, respectively. All three have been approved for NMOSD in the US and several other countries worldwide and thus provide convincing treatment options.

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“…Most of those studies focused on changes in RNFL and ganglion cell-inner plexiform layer (GCIPL) thicknesses [4][5][6][7][8] . In fact, RNFL and GCIPL analyses performed using OCT have helped to characterize ON according to the etiology, such as aquaporin-4 (AQP4) immunoglobulin G (IgG)-related ON (AQP4-ON), myelin oligodendrocyte glycoprotein (MOG) IgG-related ON (MOG-ON), and multiple sclerosis (MS)-related ON (MS-ON) [9][10][11][12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of macular changes according to the etiology of optic neuritis: a cross-sectional study

Moon,

Jung

2024

Int J Ophthalmol

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AIM: To compare the macular structure including foveal thickness among patients with optic neuritis (ON) according to the etiology and to investigate the possible correlation between structural and visual outcomes METHODS: In this retrospective cross-sectional study, the clinical data of patients with aquaporin-4 immunoglobulin G-related ON (AQP4 group, 40 eyes), myelin oligodendrocyte glycoprotein IgG-related ON (MOG group, 31 eyes), and multiple sclerosis-related ON (MS group, 24 eyes) were obtained. The retinal thickness of the foveal, parafoveal and perifoveal regions were measured. Visual acuity (VA), visual field index and mean deviation were measured as visual outcomes. RESULTS: The AQP4 group showed a significantly thinner fovea (226.4±13.4 μm) relative to the MOG (236.8±14.0 μm, P=0.015) and MS (238.9±14.3 μm, P=0.007) groups. The thickness in the parafoveal area also was thinner in the AQP4 group, though the difference in perifoveal retinal thickness was not significant. Foveal thickness was correlated with VA in the AQP4 group (coefficient ρ=-0.418, P=0.014), but not in the MOG and MS groups (P=0.218 and P=0.138, respectively). There was no significant correlation between foveal thickness and visual field test in all three groups. CONCLUSION: The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are found. Additionally, macular changes in AQP4-ON show a significant correlation with VA. The results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON, distinct from MOG-ON and MS-ON.

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Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort

Cited by 12 publications

References 30 publications

A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes

A 10-Year Single-Center Study of the Clinical Characteristics of Optic Neuritis-Related NMOSD, MS, and Double Seronegative Optic Neuritis, Together with Factors Predicting Visual Outcomes

What's new in neuromyelitis optica spectrum disorder treatment?

Comparison of macular changes according to the etiology of optic neuritis: a cross-sectional study

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