Clinical Characteristics of Patients Who Died of Coronavirus Disease 2019 in China

Abstract

Another interesting finding of this case series is that hypertension was the most common chronic comorbidity among patients who died. A previous 2020 case series 1 also reported a higher rate of hypertension among patients with COVID-19 who were admitted to intensive care units than among patients with COVID-19 who were not admitted to intensive care units. However, hypertension usually is not an independent risk factor associated with mortality in patients with sepsis. 5 According to a study from earlier this year, 6 severe acute respiratory syndrome coronavirus 2 infects the lungs through the angiotensin-converting enzyme II receptor. Further research is needed to find the mechanism of COVID-19. In addition, clinical studies are also needed to confirm whether angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could be beneficial for patients with COVID-19.Our study has some limitations. One limitation is that our data were from patients who died during late January 2020, and they may not be representative of later cases of COVID-19.This case series found that delayed intubation was common in the early stage of the COVID-19 epidemic in Wuhan. Potential reasons for the delay include lack of invasive mechanical ventilators and lack of specific clinical training for respiratory support.

Evaluation and Improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study

“…Sensitivity analyses were performed to account for potential demographic variability. Recent evidence suggest sex differences with men more likely to experience worse outcomes 16 . Therefore, in separate models, we tested interactions between each physiological and blood parameter and sex using likelihood-ratio tests (comparing a null model with the main effects only vs. a model additionally including the interaction term).…”

“…As the SARS-Cov2 pandemic has progressed, evidence has emerged regarding potentially useful blood biomarkers 1,[14][15][16][17] . Although most of these early reports contain data from small numbers of patients, a number of markers have been found to be associated with severity.…”

Clinical Characteristics, Risk Factors and Outcomes Among the First Consecutive 1,096 Patients Diagnosed with COVID-19: The Kuwait Experience

“…shown secondary bacterial infections are late manifestation of the disease process 31 6. Consult ID to consider treatment with Lopinavir-ritonavir 43 .…”

Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology

“…Basic information, such as the country/location of the study and the relative availability of ICU beds should be included wherever possible; for example, care patterns when only 1% of a hospital's beds are ICU beds will likely be different than in a hospital where they constitute 20% of hospitals beds; providing such information in the methods of a study will help readers understand the data. Similarly, information on care preferences, such as how many patients preferred not to receive mechanical ventilation (due to age, comorbidity, or other personal preference) would aid in interpreting data such as when reporting that only 20.2% of those who died with COVID-19 received this intervention (12). And transparency regarding clinical practices such as approach to the use of invasive mechanical ventilation matters.…”