Clinical Characteristics Of Patients With Tuberculosis Destroyed Lung

Rhee, Chin Kook; Yoo, Kwang Ha; Lee, Jin H.; Park, Myung J.; Kim, Woo Jae; Park, Young Bum; Hwang, Yong Il; Kim, Young S.; Jung, Ji Ye; Moon, Joon-Shik; Rhee, Yang Keun; Park, Hye K.; Lim, Jung Hwan; Park, Hye Y.; Lee, Sei W.; Kim, Yong H.; Lee, Sang H.; Yoon, Hyoung Kyu; Kim, Jin W.; Kim, Ju S.; Oh, Yeon Mok; Kim, Hui J.; Lee, Sang-Deok

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6637

Cited by 8 publications

(12 citation statements)

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“…South Korea has an intermediate prevalence of active TB, and patients with TB-destroyed lung are commonly seen there [11,12], which can partially explain why the most common underlying condition of PAT was TB-destroyed lung in the present study. In a previous study, active TB was determined to be a pertinent risk factor for VTE, and a systemic hypercoagulable state had a preponderant role over intrathoracic venous compression [13].…”

Section: Discussionmentioning

confidence: 78%

“…Most patients with PAT had a filling defect in the right or left pulmonary artery, except for one (right lower lobar arterial stump). All patients with TB-destroyed lung fulfilled the following criteria: past TB; lung parenchymal destruction and lung volume loss, and/or bronchiectatic changes in more than one lobe on the CT scan [11]. All patients with PAT after lung resection had undergone lobectomy or pneumonectomy due to lung cancer.…”

Section: Resultsmentioning

confidence: 99%

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Clinical characteristics of in-situ pulmonary artery thrombosis in Korea

Cha

Choi²,

Shin³

et al. 2015

Blood Coagulation &Amp; Fibrinolysis

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Little is known regarding the clinical features and course of in-situ pulmonary artery thrombosis (PAT). The aim of the present study was to investigate the clinical characteristics of PAT. Patients with PAT were retrospectively identified from a tertiary referral center in South Korea. A control group consisted of patients with pulmonary embolism in whom the right or left pulmonary artery was the largest pulmonary embolism-involved site. We compared various clinical parameters between the two groups. Of the 23 PAT patients, the most common underlying condition was tuberculosis-destroyed lung [11 (47.8%)], followed by pulmonary artery stump after lobectomy or pneumonectomy [7 (30.4%)]. In all patients except one, PAT was located in the right or left pulmonary artery. Computed tomography scans demonstrated that clots were completely or partially resolved less frequently in the PAT group than in the control group [4 (25%) versus 62 (90%); P < 0.001]. In the PAT group, three of the seven patients (43%) who had undergone anticoagulation therapy exhibited improvement, and one of the nine patients (11%) who had not received anticoagulation therapy experienced improvement; however, the difference was not significant. Tuberculosis-destroyed lung was the most common underlying condition in Korean PAT patients, followed by pulmonary artery stump after lung resection. The clots in patients with PAT were mostly located in the right or left pulmonary artery, and clot resolution was less frequent in the PAT group compared to the pulmonary embolism group.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Clinical characteristics of in-situ pulmonary artery thrombosis in Korea

Cha

Choi²,

Shin³

et al. 2015

Blood Coagulation &Amp; Fibrinolysis

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“…There may be two explanations -post-tuberculosis sequelae may be contributing to CLD, but equally clinicians may be more likely to initiate HIV-positive children with CLD on anti-tuberculosis treatment due to their clinical presentation and the high risk of tuberculosis among individuals living with HIV in this setting. Post-tuberculosis lung disease can involve airflow obstruction and/or restrictive ventilatory defects, as well as impairment in gas exchange (35)(36)(37)(38). Airflow obstruction is associated with decreased capacity to completely expel air out of the lungs and is probably due to inflammation-induced narrowing of airways (38).…”

Section: Accepted Articlementioning

confidence: 99%

Chronic lung disease in children and adolescents with HIV: a case–control study

McHugh

Rehman

Simms

et al. 2020

Tropical Med Int Health

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Objective: To describe the features of HIV-associated chronic lung disease (CLD) in older children and adolescents living with HIV and to examine the clinical factors associated with CLD. This is a post-hoc analysis of baseline data from the BREATHE clinical trial (ClinicalTrials.gov, NCT02426112). Methods:Children and adolescents aged 6-19 years were screened for CLD (defined as a FEV1 z-score <-1 with no reversibility post-bronchodilation with salbutamol) at two HIV clinics in Harare, Zimbabwe and Blantyre, Malawi. Eligible participants with CLD (cases) were enrolled, together with a control group without CLD (frequency-matched by age group and duration on ART) in a 4:1 allocation ratio. A clinical history and examination was undertaken. The association between CLD and a priori-defined demographic and clinical covariates was investigated using multivariable logistic regression. Results:Of the 1,585 participants screened, 419 (32%) had a FEV 1 z-score <-1, of whom 347 were enrolled as cases (median age 15.3 years ]; 48.9% female), and 74 with FEV1 z-score>0 as controls (median age 15.6 years ; 62.2% female). Amongst cases, current respiratory symptoms including cough and shortness of breath were reported infrequently (9.3% and 1.8%, respectively). However, 152 (43.8%) of cases had a respiratory rate above the 90th centile for their age. Wasting and

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“…Many Asian patients have TDL and many of them have an airflow obstruction. Rhee et al 45 showed that among 595 patients with TDL from 21 hospitals, 457 (76.8%) had an airflow obstruction. Lung function, number of exacerbations and the decline of forced expiratory volume in 1 s (FEV 1 ) were comparable to those of COPD.…”

Section: Tuberculosis-destroyed Lungmentioning

confidence: 99%

“…Lung function, number of exacerbations and the decline of forced expiratory volume in 1 s (FEV 1 ) were comparable to those of COPD. According to a previous report, 45 long-acting muscarinic antagonist (LAMA) and/or ICS + long-acting beta agonist (LABA) can be effective for TDL. Both inhalers significantly increased FEV 1 and triple therapy (ICS + LABA with LAMA) resulted in greater improvement of lung function.…”

Section: Tuberculosis-destroyed Lungmentioning

confidence: 99%

Management of COPD in Asia: A position statement of the Asian Pacific Society of Respirology

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is a major disease in Asia. However, how to manage specifically Asian COPD patients has not been proposed. Awareness of COPD is very low and underdiagnosis/undertreatment is common in Asian countries. Low utilization of pulmonary function test and inhalers is also a problem. Moreover, high smoking prevalence and air pollution are barriers to managing Asian patients with COPD. The relatively low body mass index of Asian patients with COPD can increase their risk for experiencing adverse effects from COPD drugs. Physicians should consider the unique features of Asian populations with COPD such as the high prevalence rates of bronchiectasis and tuberculosis‐destroyed lungs, biomass smoke exposure and parasitic infection.

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Clinical Characteristics Of Patients With Tuberculosis Destroyed Lung

Cited by 8 publications

References 0 publications

Clinical characteristics of in-situ pulmonary artery thrombosis in Korea

Clinical characteristics of in-situ pulmonary artery thrombosis in Korea

Chronic lung disease in children and adolescents with HIV: a case–control study

Management of COPD in Asia: A position statement of the Asian Pacific Society of Respirology

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