Clinical characteristics of patients with Parkinson's disease with reduced 123I-metaiodobenzylguanidine uptake in the major salivary glands and heart

Ebina, Junya; Mizumura, Sunao; Morioka, Harumi; Shibukawa, Mari; Nagasawa, Junpei; Yanagihashi, Masaru; Hirayama, Takehisa; Ishii, Nobutomo; Kobayashi, Yukio; Inaba, Akira; Orimo, Satoshi; Kano, Osamu

doi:10.1016/j.jns.2024.122932

Journal of the Neurological Sciences

2024

DOI: 10.1016/j.jns.2024.122932

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Clinical characteristics of patients with Parkinson's disease with reduced 123I-metaiodobenzylguanidine uptake in the major salivary glands and heart

Junya Ebina,

Sunao Mizumura,

Harumi Morioka

et al.

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2024

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Cited by 3 publications

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Letter to the editor

Baba,

Totsune,

Takeda

2024

Journal of the Neurological Sciences

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Letter to the editor

Baba,

Totsune,

Takeda

2024

Journal of the Neurological Sciences

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Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy

Ebina,

Mizumura,

Shibukawa

et al. 2024

Clinical Parkinsonism & Related Disorders

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Iodine-123 Metaiodobenzylguanidine (I-123 MIBG) in Clinical Applications: A Comprehensive Review

Chang,

Peng,

Chen

et al. 2024

Pharmaceuticals

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Iodine-123 metaiodobenzylguanidine (I-123 MIBG) is a crucial radiopharmaceutical widely used in nuclear medicine for its diagnostic capabilities in both cardiology and oncology. This review aims to present a comprehensive evaluation of the clinical applications of I-123 MIBG, focusing on its use in diagnosing and managing various diseases. In cardiology, I-123 MIBG has proven invaluable in assessing cardiac sympathetic innervation, particularly in patients with heart failure, where it provides prognostic information that guides treatment strategies. In oncology, I-123 MIBG is primarily utilized for imaging neuroendocrine tumors, such as neuroblastoma and pheochromocytoma, where it offers high specificity and sensitivity in the detection of adrenergic tissue. Additionally, its role in neurology, specifically in differentiating between Parkinson’s disease, dementia, and Lewy body dementia, has become increasingly significant due to its ability to identify postganglionic sympathetic dysfunction. Despite its established clinical utility, the use of I-123 MIBG is not without limitations, including variability in imaging protocols and interpretation challenges. This review will explore these issues and discuss emerging alternatives, while also highlighting areas where I-123 MIBG continues to be a gold standard. By synthesizing the current research, this article aims to provide a clear understanding of the strengths, limitations, and prospects of I-123 MIBG in clinical practice.

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Clinical characteristics of patients with Parkinson's disease with reduced 123I-metaiodobenzylguanidine uptake in the major salivary glands and heart

Cited by 3 publications

References 50 publications

Letter to the editor

Letter to the editor

Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy

Iodine-123 Metaiodobenzylguanidine (I-123 MIBG) in Clinical Applications: A Comprehensive Review

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