Clinical characteristics of pediatric external auditory canal cholesteatoma

Jang, Chul Ho; Kim, Young Yoon; Seong, Jong Yuap; Kang, Sung Hoon; Jung, Eun Kyung; Sung, Chung Ki; Kim, Seung Beom; Cho, Yong Beom

doi:10.1016/j.ijporl.2016.05.029

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…It is known that inflammation is an evolutionarily conserved process of protection and a critical survival mechanism [ 8 ]. It is composed of complex sequential changes in the tissue to eliminate the initial cause of the cell injury, which may have been caused by infectious agents or substances from their metabolism (microorganisms and toxins), as well as by physical agents (radiation, burn, and trauma), or chemicals (caustic substances) [ 9 , 10 ]. The signs of inflammation are local redness, swelling, pain, heat, and loss of function [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

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Section: Introductionmentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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“…The capability of performing an accurate assessment in congenital cholesteatomas is further compromised by difficulties in examining the middle ear in pediatric patients 20 . Potential pitfalls include the presence of narrow external auditory canals and an uncooperative child.…”

Section: Introductionmentioning

confidence: 99%

“…19 The capability of performing an accurate assessment in congenital cholesteatomas is further compromised by difficulties in examining the middle ear in pediatric patients. 20 Potential pitfalls include the presence of narrow external auditory canals and an uncooperative child. Despite these critical challenges, the otoscope, which is the most common instrument for middle ear examination, has undergone few changes since the mid-19th century.…”

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confidence: 99%

Imaging guidance for cholesteatoma surgery using tissue autofluorescence

Yang

Farrell

et al. 2023

J. Biomed. Opt.

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.SignificanceCholesteatoma is an expansile destructive lesion of the middle ear and mastoid, which can result in significant complications by eroding adjacent bony structures. Currently, there is an inability to accurately distinguish cholesteatoma tissue margins from middle ear mucosa tissue, causing a high recidivism rate. Accurately differentiating cholesteatoma and mucosa will enable a more complete removal of the tissue.AimDevelop an imaging system to enhance the visibility of cholesteatoma tissue and margins during surgery.ApproachCholesteatoma and mucosa tissue samples were excised from the inner ear of patients and illuminated with 405, 450, and 520 nm narrowband lights. Measurements were made with a spectroradiometer equipped with a series of different longpass filters. Images were obtained using a red-green-blue (RGB) digital camera equipped with a long pass filter to block reflected light.ResultsCholesteatoma tissue fluoresced under 405 and 450 nm illumination. Middle ear mucosa tissue did not fluoresce under the same illumination and measurement conditions. All measurements were negligible under 520 nm illumination conditions. All spectroradiometric measurements of cholesteatoma tissue fluorescence can be predicted by a linear combination of emissions from keratin and flavin adenine dinucleotide. We built a prototype of a fluorescence imaging system using a 495 nm longpass filter in combination with an RGB camera. The system was used to capture calibrated digital camera images of cholesteatoma and mucosa tissue samples. The results confirm that cholesteatoma emits light when it is illuminated with 405 and 450 nm, whereas mucosa tissue does not.ConclusionsWe prototyped an imaging system that is capable of measuring cholesteatoma tissue autofluorescence.

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“…Inflammation is known to be an evolutionarily conserved process of protection and a critical survival mechanism (Liu et al, 2017). It is made up of a series of complex changes in the tissue that are meant to eliminate the source of the cell injury, which may have been caused by chemicals, infectious agents, toxins, or physical agents such as radiation, burn, and trauma (Jang et al, 2016;Fialho et al, 2018). Local redness, swelling, pain, heat, and loss of function are all symptoms of inflammation (Virshette et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of different extracts from aerial parts of Zilla spinosa (L.) Prantl

Mecheri

Mahfouf

Smati

et al. 2023

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Zilla spinosa L. is a medicinal plant widely used in traditional Algerian phytotherapy against urinary lithiasis. The present study aims to evaluate the antioxidant and anti-inflammatory effects of different extracts from the aerial part of this plant. The antioxidant activity of the extracts was examined by two different methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cupric reducing antioxidant capacity (CUPRAC). The anti-inflammatory activity of Z. spinosa was determined by the protein denaturation method. The qualitative phytochemical screening shows the presence of the majority of secondary metabolites in the aerial parts except anthraquinones and steroids, on the other hand, the root is characterized by the absence of several metabolites except tannins and coumarins.The ethyl acetate fraction displayed the highest antioxidant capacity (IC50 value: 10.47±0.18 μg/mL in DPPH assay, and A0.50 value: 40.89 ± 0.86 μg/mL in CUPRAC). The percentage of inhibition of BSA denaturation (0.2%) is proportional to the concentration of the different plant extracts, where the highest percentage was recorded in the concentrations of ethyl acetate 500; 250 μg/mL compared to Diclofenac (75 mg/3 mL), in contrast to the aqueous extract which gave non-significant results compared to the standards (p≥5℅). In comparison to the standards used in this study, the ethyl acetate extract demonstrated better DPPH inhibitory activity, while all organic extracts demonstrated lower CUPRAC inhibitory activity but higher anti-inflammatory activity.

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Clinical characteristics of pediatric external auditory canal cholesteatoma

Cited by 10 publications

References 13 publications

Plants as Sources of Anti-Inflammatory Agents

Plants as Sources of Anti-Inflammatory Agents

Imaging guidance for cholesteatoma surgery using tissue autofluorescence

Antioxidant and anti-inflammatory activities of different extracts from aerial parts of Zilla spinosa (L.) Prantl

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