Clinical characteristics of peripheral exudative hemorrhagic chorioretinopathy and its response to bevacizumab therapy

Pınarcı, Eylem Yaman; Kilic, Ilkay; Bayar, Sezin Akça; Akkoyun, İmren; Yılmaz, Gürsel

doi:10.1038/eye.2012.239

Cited by 13 publications

(14 citation statements)

References 3 publications

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“…Visual acuity decreased in the other 3 patients due to macular involvement despite repeated injections. 8 The efficacy of intravitreal ranibizumab injection against PEHC-associated lesions has also been demonstrated. 11 We observed no reduction in vision during follow-up in our patients without macular involvement or macula-threatening lesions that we monitored without treatment.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Following without treatment is recommended for cases without affected central vision or macular involvement, and the disease may spontaneously regress in most of these cases. 9 Laser photocoagulation or photodynamic therapy may be applied in cases with macula-threatening findings or peripheral polyps.…”

Section: Discussionmentioning

confidence: 99%

“…9 Alforja et al 7 treated an eye with PEHC-related subretinal neovascularization and subfoveal fluid with a single IVB injection (1.25 mg/0.05 mL) and observed that the subfoveal fluid and lesion resolved, leaving subretinal fibrosis. In a larger study, Pınarcı et al 8 evaluated 23 eyes with PEHC of 15 patients and reported that lesions were stable or regressed in 11 patients (47.8%). They treated 12 patients with IVB injection, and 9 eyes (39.1%) showed lesion regression with atrophy and scarring after 2 or 3 injections.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Course of Patients with Peripheral Exudative Hemorrhagic Chorioretinopathy

Cebeci¹,

Dere²,

Bayraktar³

et al. 2016

tjo

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Objectives:To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC).Materials and Methods:Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively.Results:This study included 21 eyes of 12 patients. Four (33.3%) of the patients were male and 8 (66.7%) were female and ages ranged between 73 and 89 years. Eight (66.7%) of the patients were referred to us with the diagnosis of choroidal mass. Unilateral involvement was found in 3 and bilateral involvement in 9 patients. Temporal quadrants were involved in all eyes. Fifteen eyes (71.4%) had subretinal hemorrhage and hemorrhagic/serous retinal pigment epithelial detachment, 11 (52.4%) had lipid exudation, 5 (23.8%) had chronic retinal pigment epithelium alterations, 2 (9.5%) had subretinal fibrosis and 1 (4.8%) had vitreous hemorrhage. PEHC lesions were accompanied by drusen in 11 eyes (52.4%), geographic atrophy in 2 eyes (9.5%), and choroidal neovascularization scar in 2 eyes (9.5%). Treatment was done in both eyes of a patient for lesions which threatened the macula, in a patient with bilateral macular edema and in a patient with vitreous hemorrhage. The remaining eyes were followed-up without any treatment because the lesions did not threaten the macula and they showed no progression during follow-up.Conclusion:PEHC is a degenerative disease of peripheral retina that is seen in older patients, and signs of age-related macular degeneration (AMD) may accompany this pathology. Especially in patients with AMD findings, the peripheral retina must be evaluated carefully for existing PEHC lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Course of Patients with Peripheral Exudative Hemorrhagic Chorioretinopathy

Cebeci¹,

Dere²,

Bayraktar³

et al. 2016

tjo

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“…Reduction in visual acuity appears when the peripheral subretinal exudation, fluid, or hemorrhage approaches the macula or choroidal neovascular membranes and CME appear. Several case series have described the use of intravitreal bevacizumab[ 5 6 ] and ranibizumab[ 7 ] for successful management of these conditions.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Hemorrhagic Retinal Detachment Secondary to Peripheral Exudative Hemorrhagic Chorioretinopathy

Semidey

Taisan

Schatz

et al. 2021

Middle East African Journal of Ophthalmology

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The purpose of the study is to report a case of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), managed surgically with favorable visual outcome. A 66-year-old female presented with painless visual loss due to dense vitreous and subretinal hemorrhage extending from the far periphery to the macula. Pars plana vitrectomy (PPV) with subretinal tissue plasminogen activator (TPA) injection was performed resulting in good anatomical and visual outcome. PEHCR can present with severe visual loss. Surgical management with PPV and subretinal TPA injection might result in favorable anatomical and visual outcome.

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“…In der bisher größ-ten angelegten Studie von Shields et al wurden lediglich bei 7 % der Fälle Visusverschlechterungen aufgrund subretinaler Flüssigkeit oder Hämorrhagien im Bereich der Makula beschrieben [5]. Zur Behandlung einer symptomatischen PEHCR existieren bislang nur wenige Berichte über den Einsatz von intravitrealem Anti-VEGF [3,4]. In Weitwinkelangiographieuntersuchungen zeigen sich periphere Gefäßveränderungen, die choroidalen Neovaskularisationen (CNV) und polypoidalen choroidalen Neovaskularisationen (PCV) entsprechen.…”

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Unklarer Aderhauttumor mit Blutungen

et al. 2018

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Clinical characteristics of peripheral exudative hemorrhagic chorioretinopathy and its response to bevacizumab therapy

Cited by 13 publications

References 3 publications

Clinical Features and Course of Patients with Peripheral Exudative Hemorrhagic Chorioretinopathy

Clinical Features and Course of Patients with Peripheral Exudative Hemorrhagic Chorioretinopathy

Surgical Management of Hemorrhagic Retinal Detachment Secondary to Peripheral Exudative Hemorrhagic Chorioretinopathy

Unklarer Aderhauttumor mit Blutungen

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