Clinical characteristics of pigment dispersion syndrome in Chinese patients

Qing, Guoping; Wang, N; Tang, Xin; Zhang, S; Chen, H

doi:10.1038/eye.2008.328

Cited by 18 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Defects in iris transillumination are not common in our sample as well as in other noncaucasian patients 17 probably due to low incidence of light color iris compared to the dark and morphological compact iris stroma of Latin population. These findings suggest that the clinical presentation in our population can be different, and highlight the importance of a careful and complete clinical exam, including gonioscopy to enhance rate of diagnosis.…”

Section: Discussionmentioning

confidence: 49%

Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population

Goyeneche

Hernandez-Mendieta

Rodríguez

et al. 2015

Journal of Current Glaucoma Practice

View full text Add to dashboard Cite

Objective: To determine the progression of pigment dispersion syndrome (PDS) into pigmentary glaucoma (PG) in a population at the Central Military Hospital in Bogotá, Colombia.Materials and methods: A retrospective study was conducted, based on a review of medical records of patients with PDS evaluated in the Glaucoma Clinic. Data were collected in a database in excel and subsequently analyzed with the software Statistical Package for the Social Sciences (SPSS), performing Chi-square test analysis and Spearman’s rho test.Results: Forty-eight eyes of 24 patients were included. Forty-two percent were women and 58% were men. Pigmentation of the trabecular meshwork was the most frequent clinical sign (100%), followed by Krukenberg’s spindle (91.7%), the least frequent were the iris concavity and iris heterochromia (4.2%), the average of the spherical equivalent was of - 1.33 (SD 2.07).The rate of conversion of PDS to PG was 37.5%, after an average follow-up of 50.7 months. Having an intraocular pressure (IOP) greater than 21 mm Hg was statistically the only significant risk factor for conversion.Conclusion: We found several differences in frequency and clinical signs in these patients in contrast to previous data, probably due to different racial characteristics.The rate of progression is similar to previous reports despite of heterogeneity of these. Having IOP > 21 mm Hg was the only risk factor associated with progression in this sample.How to cite this article: Gomez Goyeneche HF, Hernandez-Mendieta DP, Rodriguez DA, Sepulveda AI, Toledo JD. Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population. J Curr Glaucoma Pract 2015;9(3):69-72.

show abstract

Section: Discussionmentioning

confidence: 49%

Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population

Goyeneche

Hernandez-Mendieta

Rodríguez

et al. 2015

Journal of Current Glaucoma Practice

View full text Add to dashboard Cite

show abstract

“…A readily recognisable feature of this disease is the wide dispersion of pigment in intraocular tissues, especially on the corneal endothelium and in trabecular meshwork 31 . Our previous study in a porcine eye perfusion model suggested that iris pigment particles induced TM stress fibers, reduced TM phagocytosis, adhesion, and motility, and resulted in a significant IOP elevation 25 .…”

Section: Discussionmentioning

confidence: 99%

Ocular Hypotension, Actin Stress Fiber Disruption and Phagocytosis Increase by RKI-1447, a Rho-Kinase Inhibitor

Dang¹,

Wang²,

Shah³

et al. 2018

Preprint

View full text Add to dashboard Cite

Objective: The Rho GTPase/Rho kinase pathway is an important target in glaucoma treatment. This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor developed for cancer treatment, in a porcine ex vivo pigmentary glaucoma model. Materials and Methods:Twenty-eight fresh porcine anterior chambers were perfused with pigment medium (1.67×10 7 pigment particles/ml) for 48 hours before being subjected to the RKI-1447 (n=16) or the vehicle control (n=12). Another twelve eyes with normal medium perfusion served as the control. The intraocular pressure (IOP) was recorded at two-minute intervals and the outflow facility was calculated. To investigate the intracellular mechanism of the IOP reduction, primary trabecular meshwork cells were exposed to RKI-1447 or the vehicle control and then analyzed for changes in cytoskeleton, motility, and phagocytosis.

show abstract

“…Striking spoke-like iris transillumination defects are commonly seen in Caucasian PDS patients [1,2,4]. In this case, however, a greater content of pigment granules in melanocytes and iris stroma may have prevented such transillumination, as with most other Chinese PDS patients reported previously [5].…”

Section: Meeting Presentation Nomentioning

confidence: 80%

“…Characteristic findings of PDS include Krukenberg spindle, homogenous trabecular meshwork (TM) pigmentation, and spoke-like mid-peripheral iris transillumination defects [1][2][3][4][5]. Primary PDS usually affects bilateral eyes, although the morbidity and manifestations may be asymmetric.…”

mentioning

confidence: 97%

Pigment dispersion secondary to anterior chamber angle recession

Qing

Wang

2011

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Dear Editor: Irido-zonular and/or -lenticular disruption, mostly due to posterior bowing of the iris, is believed to be the mechanism of primary pigment dispersion syndrome (PDS). Characteristic findings of PDS include Krukenberg spindle, homogenous trabecular meshwork (TM) pigmentation, and spoke-like mid-peripheral iris transillumination defects [1][2][3][4][5]. Primary PDS usually affects bilateral eyes, although the morbidity and manifestations may be asymmetric. Herein, we report an unusual case of monocular pigment dispersion secondary to traumatic anterior chamber angle recession.A 33-year-old male complained of blurred vision and distending pain in his right eye for more than 1 year. He sustained blunt ocular trauma by a wooden stick 10 years prior. He had no family history of either glaucoma or PDS. On admission, his visual acuity was 20/200 OD and 20/20 OS. A Krukenberg spindle was discerned in his right eye (Fig. 1a), along with posterior bowing of the mid-peripheral iris. A Zentmayer ring was visualized on the rear surface of the crystalline lens. Homogenous heavy TM pigmentation and 270º of anterior chamber (AC) angle recession were revealed on gonioscopy (Fig. 1b). Spoke-like iris transillumination defects were not seen. His left eye was unremarkable on both biomicroscopy and gonioscopy, with minimal TM pigmentation and flat iris configuration (Fig. 1c). The vertical cup/disc ratio was 0.9 OD and 0.3 OS. The intraocular pressure (IOP) was 52 OD and 17 OS. Refraction revealed −0.25 diopters in both eyes. Humphrey visual field analysis showed inferior arcuate scotoma in the right eye and normal field in the left. Ultrasound biomicroscopy (UBM) revealed posterior bowing of the iris and irido-zonular and -lenticular contact in the right eye (Fig. 1d), and flat iris in the left.The patient underwent trabeculectomy for pigmentary glaucoma in his right eye, with postoperative IOP in the teens during 6 years of follow-up. The iris became flat, and no more pigment dispersion was discerned after the surgery. Visual field deterioration was not detected with Humphrey visual field analysis postoperatively. The left eye did not show any signs of pigment dispersion or other ocular disorders after 6 years of surveillance.Pigment dispersion may occur after ocular trauma, intraocular lens implantation, iritis, and so on [1,4,6]. However, such secondary pigment dispersion differs from primary PDS, in that the former usually does not have Krukenberg spindle and iris transillumination defects. Krukenberg spindle is more likely to be the result of continuous pigment shedding like primary PDS, which is secondary to irido-zonular contact. The typical appearance This manuscript has not been published or submitted for publication elsewhere. We certify that all applicable institutional and governmental regulations concerning the ethical use of human subjects were followed during this research.

show abstract

Clinical characteristics of pigment dispersion syndrome in Chinese patients

Cited by 18 publications

References 14 publications

Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population

Pigment Dispersion Syndrome Progression to Pigmentary Glaucoma in a Latin American Population

Ocular Hypotension, Actin Stress Fiber Disruption and Phagocytosis Increase by RKI-1447, a Rho-Kinase Inhibitor

Pigment dispersion secondary to anterior chamber angle recession

Contact Info

Product

Resources

About