Clinical characteristics of polycystic ovary syndrome in Indian women

Ramanand, Sunita J.; Ghongane, Balasaheb B.; Ramanand, Jaiprakash; Patwardhan, Milind; Ghanghas, Ravi R.; Jain, Suyog

doi:10.4103/2230-8210.107858

Cited by 113 publications

(104 citation statements)

References 19 publications

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“…Ramanand et al did a study on clinical characteristics of PCOS in Indian women and reported menstrual irregularities as the chief complaint in 100% of women, 44.16% patients showed presence of acanthosis nigricans and 44.16% women had hirsutism. 13 Antral follicles count is a potentially useful predictor of the outcome of ovarian stimulation in PCOS women. 14 Kandil et al did a study on sonographic assessment of ovarian reserve before and after laparoscopic ovarian drilling in PCOS and reported pre-treatment mean antral follicles count in LOD group was 16.5±1.3.…”

Section: Resultsmentioning

confidence: 99%

Comparison of clinical outcomes in clomiphene citrate resistant infertile polycystic ovarian syndrome women after treatment with laparoscopic ovarian drilling (LOD) versus gonadotropins

Rupa

Jain

Dutta

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Infertility is the inability of a sexually active, non-contracepting couple to achieve pregnancy in one year. Objective of present study was to compare the clinical outcome of laparoscopic ovarian drilling with gonadotropin ovulation induction in patients with clomiphene resistant Polycystic Ovarian Syndrome.Methods: Present study was a comparative interventional study conducted at the Institute of Obstetrics and Gynaecology, Sir Ganga Ram Hospital, New Delhi for a period of one and a half year. We enrolled 40 clomiphene citrate resistant infertile PCOS women who were undergoing treatment for infertility, after taking written informed consent. The women were randomly divided into two equal groups: one for LOD (laparoscopic ovarian drilling) (group A) and other for gonadotropins (group B).Results: Out of 20, 16 women (80%) in group A ovulated with clomiphene citrate and 18 women (90%) ovulated in group B. Pregnancy was the second major outcome and 4 women (20%) in group A with clomiphene citrate got pregnant and 9 women (45%) got pregnant in group B.Conclusions: Out of 20, 16 women (80%) in group A ovulated with clomiphene citrate and 18 women (90%) ovulated in group B. Pregnancy was the second major outcome and 4 women (20%) in group A with clomiphene citrate got pregnant and 9 women (45%) got pregnant in group B. The treatment option can be selected and tailored according to the individual needs and desires of the patient.

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Section: Resultsmentioning

confidence: 99%

Comparison of clinical outcomes in clomiphene citrate resistant infertile polycystic ovarian syndrome women after treatment with laparoscopic ovarian drilling (LOD) versus gonadotropins

Rupa

Jain

Dutta

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…Another study by Ramanand et al is also in concordance with our observations. 8 He observed that irregular cycles in 100% of their study participants, whereas infertility was present in 21%. Another study from Jammu and Kashmir observed menstrual disturbances in 65% of the PCOS women, whereas 35% of the patients had normal menstrual cycles.…”

Section: Discussionmentioning

confidence: 99%

Pattern of dermatologic manifestations in polycystic ovarian disease cases from a tertiary care hospital

Jain

Singh

et al. 2018

Int J Adv Med

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Background: Dermatologists often play a significant role in its management. Cutaneous features of hyperandrogenism in Polycystic ovarian syndrome (PCOS) have varied presentation. Aim of this study was the pattern of dermatologic manifestations in polycystic ovarian disease in northern Indian females.Methods: Patients registering for treatment of polycystic ovarian disease at Dermatology outpatients department during April 2016 to March 2017 formed the study population. Residents interviewed the study subjects at the OPD. General physical examination, systemic examination, breast and pelvic examination, along with detailed dermatological examination were conducting after taking the history. Hormonal analysis was performed after an overnight fasting using enzyme immunoassay.Results: FSH and LH levels were 5.05±1.86 IU/L and 8.14±5.21 IU/L respectively. Testosterone levels were found to be 61.01±25.32 ng/dl. DHEAS levels among them were 130.05±41.21μg/dl. Two commonest cutaneous manifestations were hirsutism and acne seen in 83.8% and 59.5% of subjects. Female pattern hair loss was seen in 45.6% females. Three most frequent hormonal abnormalities noted in our study subjects were raised L/H ratio, testosterone and LH levels seen in approximately 45%, 35% and 21% cases.Conclusions: The cutaneous manifestations of PCOS reserve a major role in its management by dermatologists. A lifestyle modification along with systemic treatment remains mainstay of treatment. Monitoring for the foreseen cardiovascular risks should start early to downgrade the morbidity.

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“…1,7 The prevalence of metabolic disorders in women with PCOS is higher than in the healthy population, with type 2 diabetes occurring at the highest frequency (3-7 times), especially in Indians. 2,44 Other frequent disorders include hirsutism (85-90%) symptoms of metabolic syndrome (MS, approximately 40%), obesity/ overweight (40-60%), lipid disorders, arterial hypertension (approximately 20%) ( Table 1). It is worth noting that any excessive weight in these patients impairs the regularity of menstrual bleeding and responses to metformin and insulin treatment, exacerbates the symptoms of hyperandrogenism and also increases cardiovascular risk (Fig.…”

Section: Discussionmentioning

confidence: 99%

The pathogenesis and treatment of polycystic ovary syndrome: What’s new?

Bednarska¹,

Siejka²

2017

Adv Clin Exp Med

227

148

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Polycystic ovary syndrome (PCOS) is currently the leading cause of menstrual complications in women. It is characterized by clinical and/or biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged and/or polycystic ovaries in ultrasound images (12 or more small bubbles located circumferentially and/or ovarian volume > 10 mL). It is often comorbid with hyperinsulinemia, dyslipidemia, overweight or obesity, and is a risk factor for the development of diabetes and cardiovascular diseases (CVDs). The treatment of patients with PCOS depends on the prevailing symptoms. The aim of this paper is to present the etiopathogenesis, clinical and biochemical implications, and non-pharmacological and pharmacological treatment options -those approved by worldwide scientific organizations as well as new therapies whose initial results are encouraging enough to prompt researchers to explore them further.

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Clinical characteristics of polycystic ovary syndrome in Indian women

Cited by 113 publications

References 19 publications

Comparison of clinical outcomes in clomiphene citrate resistant infertile polycystic ovarian syndrome women after treatment with laparoscopic ovarian drilling (LOD) versus gonadotropins

Comparison of clinical outcomes in clomiphene citrate resistant infertile polycystic ovarian syndrome women after treatment with laparoscopic ovarian drilling (LOD) versus gonadotropins

Pattern of dermatologic manifestations in polycystic ovarian disease cases from a tertiary care hospital

The pathogenesis and treatment of polycystic ovary syndrome: What’s new?

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