Clinical characteristics of preterm ovarian hyperstimulation syndrome: seven cases from China and 14 cases from the literature

Sun, Yuanyuan; Chen, Cuie; Di, Tianwei; Zhu, Yanke; Zhu, Ronghe; Chen, Shujun; Yan, Qian

doi:10.1080/09513590.2019.1597345

Cited by 5 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No symptoms of estrogen were reported in 21 POHS in spite of very high E 2 , except 5 cases of stage 2 thelarche and one case of vaginal bleeding. 15,16 This is explained by decreased sensitivity of peripheral E 2 receptors as a result of immature gonadal axis. 5,15,16 In our case, stage 2 thelarche, increased size of uterus and increased endometrium thickness were detected.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 This is explained by decreased sensitivity of peripheral E 2 receptors as a result of immature gonadal axis. 5,15,16 In our case, stage 2 thelarche, increased size of uterus and increased endometrium thickness were detected. These different clinical presentations support the idea that sensitivity of peripheral E 2 receptors can vary among people.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies

et al. 2020

View full text Add to dashboard Cite

Background. Preterm ovarian hyperstimulation syndrome (POHS) is an uncommon disorder characterized by prematurity, hypogastric and upper leg swelling, high serum estradiol and gonadotropin levels, and ovarian cysts. Immaturity of the gonadal axis is accepted as the cause. But still, other etiological factors are suspected. Case. A preterm baby who was born at 24 gestational weeks was referred to our clinic for ambiguous genitalia on day 118 of life. Labia majora and clitoris was edematous. Clitoris length was 1.5 cm. On laboratory evaluation: 17OH-Progesterone: 1.84 ng/ml, dehydroepiandrosterone sulphate (DHEA-S): 139 μg/dl, total testosterone (T.T): 88 ng/dl, luteinizing hormone (LH): 22.5 mIU/l, Follicle stimulating hormone (FSH): 15.7 mIU/l, estradiol (E2): 447 pg/ml. Karyotype analysis was 46, XX. There was a 25x14x12 mm ovarian cyst detected on ultrasound. On follow-up, E2 levels and cyst size increased, and there was 4 mm pericardial effusion on echocardiography at the time. Conclusion. In this paper, we present a case with POHS and to discuss possible pathophysiological mechanisms and treatment. This is the first case of POHS developing pericardial effusion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A recent study (41) showed that the high gonadotrophin levels of preterm girls decrease between 38 and 42 weeks of post-conception age, concurrently with a steep increase of estradiol, even if LH and estradiol are still positively correlated between 4 and 6 months of life. Estradiol in preterm girls increase later than testosterone in preterm boys and its peak is strongly correlated with uterus and breast growth (42). Estrogen receptor alpha is expressed in the fetal breast gland after the 30th week of gestation (43), for this reason breast development in usually absent in severely premature infants.…”

Section: Figures 1 2 Summarize Prenatal and Early Postnatal Changes mentioning

confidence: 99%

“…The ovarian hyperstimulation syndrome has been described as a clinical consequence of the intensive HPG axis activity in preterm girls (42). Sedin et al (44) first reported this syndrome in 4 severely preterm girls at a post-conceptional age slightly preceding the expected time of delivery, as edema of the vulva, hypogastric area and thighs, associated with high estradiol levels and multiple ovarian cysts.…”

Section: Figures 1 2 Summarize Prenatal and Early Postnatal Changes mentioning

confidence: 99%

See 1 more Smart Citation

Ontogeny of Hypothalamus-Pituitary Gonadal Axis and Minipuberty: An Ongoing Debate?

Bizzarri

Cappa

2020

Front. Endocrinol.

View full text Add to dashboard Cite

In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

Habiba¹,

Guo²,

Benagiano³

2023

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background: The occurrence of vaginal bleeding in early neonatal life has been observed for centuries and was considered a consequence of the sudden drop in circulating hormones following birth. As such, neonatal uterine bleeding was dismissed as having no clinical significance. Interest in the phenomenon was renewed when a new theory suggested a link between neonatal uterine bleeding (NUB) and accelerated endometrial maturation. This theory was based on the observation of a higher incidence of NUB in babies born post-term or after pregnancies complicated by intrauterine growth restriction, preeclampsia, or blood group incompatibility. Objective: The objective of this study was to review of available evidence on the pathogenesis of NUB. Method: Review of available literature using Medline search (August 2022, no limit on start date or language) to identify articles that may link NUB with features of the uterus and/or endometrium. Outcome: The fetal endometrial responses differ from that of the adult. In the fetus, the endometrium features progestogenic response only in a minority of cases. The endometrium in most newborn girls does not exhibit secretory or decidual changes which indicate lack of progesterone response. Most newborn girls do not have visible bleeding. Animal studies linked exogenous progestogen exposure during the period of organogenesis to poor endometrial gland development, progesterone resistance, and to alterations of reproductive performance. Although the fetal endometrium may not exhibit a full proliferative response, it is clearly sensitive to circulating estrogens. Molecular mechanisms involved in NUB may include “ontogenetic progesterone resistance.” Conclusion and Outlook: Endometrial development and its response to withdrawal of hormones at birth varies and may be affected by intrauterine stressors and gestational age. Factors that affect endometrial development during fetal life and in preterm neonates can have implications on future reproductive performance.

show abstract

Clinical characteristics of preterm ovarian hyperstimulation syndrome: seven cases from China and 14 cases from the literature

Cited by 5 publications

References 20 publications

Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies

Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies

Ontogeny of Hypothalamus-Pituitary Gonadal Axis and Minipuberty: An Ongoing Debate?

In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

Contact Info

Product

Resources

About