Clinical characteristics of primary cutaneous lymphoma: analysis from two centres in China

Shi, Haoze; Liu, Y.‐X.; Jiang, Yanyun; Chen, S.‐L.; Xu, Xiu-Lian; Lu, Xiaomei; Zhang, W.; Zeng, Xiaofeng; Zhou, Guangjun; Sun, Jianfang; Chen, H.

doi:10.1111/bjd.18266

Cited by 5 publications

(12 citation statements)

References 7 publications

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“…Regarding extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT), several authors have indicated a higher frequency of this condition in Asian countries compared to in Western countries and a strong association between Epstein-Barr virus (EBV) and ENKTCL in Asian populations [ 33 – 35 ]. However, we found only 1 case (0.7%) of ENKTCL-NT in our study, which was lower than reported in other Asian countries [ 8 – 10 , 36 ]. In our center experience, many patients with ENKTCL-NT present with extracutaneous manifestations, this can be the explanation of a low rate of primary cutaneous ENKTCL-NT.…”

Section: Discussioncontrasting

confidence: 92%

“…BioMed Research International reported worldwide [3-6, 8-10, 14-16]. This finding is consistent with those reported in studies from China (94.5%) [10], Iran (96%) [17], Argentina (93%) [16], and Taiwan (92.3%) [18], but relatively higher than those from Japan (85.7%) [8] and Korea (88%) [9]. Our study emphasizes that non-Caucasian populations appeared to have a higher proportion of CTCLs than those of Caucasian populations (USA, 72.4% [6]; Netherlands and Austria, 78% [4]; Germany, 85% [5]; Switzerland, 72% [15]; Italy, 78.7% [3]).…”

Section: Discussionsupporting

confidence: 91%

“…In contrast, the incidence of CBCLs (2.2%) was much lower in our study than that reported in studies from Western countries. The median age at diagnosis (40 years) of patients with PCLs overall in our study was younger than those reported in many previous studies, particularly from Western countries such as Switzerland (56 years) [ 15 ] and Italy (64 years) [ 3 ], but was close to those reported in studies from China (44.5 years) [ 10 ] and Iran (36 years) [ 17 ]. This could be explained by a high rate of HMF, a variant particularly affects young adults, in this study.…”

Section: Discussionsupporting

confidence: 74%

“…Of the 137 PCL patients, we found that the frequency of CTCLs (97.8%) was higher than in most previous studies reported worldwide [ 3 – 6 , 8 – 10 , 14 – 16 ]. This finding is consistent with those reported in studies from China (94.5%) [ 10 ], Iran (96%) [ 17 ], Argentina (93%) [ 16 ], and Taiwan (92.3%) [ 18 ], but relatively higher than those from Japan (85.7%) [ 8 ] and Korea (88%) [ 9 ].…”

Section: Discussioncontrasting

confidence: 65%

“…There are 3 main subtypes of primary cutaneous B-cell lymphomas: primary cutaneous follicle center lymphoma (pcFCL), primary cutaneous marginal zone lymphoma (pcMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT). The prevalence of CBCLs is relatively lower in Asian compared to Western populations [ 6 , 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

Pruksaeakanan

Teyateeti

Patthamalai

et al. 2021

BioMed Research International

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Background. Primary cutaneous lymphomas (PCLs) refer to cutaneous lymphomas that primarily develop in the skin with no evidence of extracutaneous disease at the time of diagnosis. The epidemiological and clinical data of PCLs in Thailand are lacking. Objectives. To evaluate the frequency, demographic data, and clinical characteristics of different subtypes of PCLs in a tertiary care university hospital. Methods. In total, 137 patients with PCLs diagnosed in our hospital in 2008–2017 were retrospectively reviewed. Results. Of the 137 patients, 57 (41.6%) were male and 80 (58.4%) were female ( M : F = 1 : 1.4 ). The median age at diagnosis was 40 years. Most patients (134, 97.8%) had cutaneous T-cell lymphomas (CTCLs). Three patients (2.2%) had cutaneous B-cell lymphomas (CBCLs). The most common subtype was mycosis fungoides (MF) (67.9%), followed by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) (21.2%), primary cutaneous anaplastic large cell lymphoma (pcALCL) (3.6%), lymphomatoid papulosis (LyP) (1.5%), primary cutaneous gamma/delta T-cell lymphoma (pcGDTCL) (1.5%), Sézary syndrome (SS) (0.7%), extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) (0.7%), primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS) (0.7%), primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT) (1.5%), and primary cutaneous follicle center lymphoma (pcFCL) (0.7%). Most patients with MF presented with early-stage disease (84.0%), with hypopigmented MF the most common variant (42.6%). Conclusions. Compared to earlier Caucasian and Asian studies, the present study revealed a higher proportion of CTCL patients with a younger age at onset and a female predominance. MF was the most common CTCL subtype, followed by SPTCL. More than 80% of MF patients were diagnosed at an early stage.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 74%

Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

Pruksaeakanan

Teyateeti

Patthamalai

et al. 2021

BioMed Research International

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Prognostic Factors and Survival Outcomes Among Patients With Mycosis Fungoides in China

Chen

Yao

et al. 2023

JAMA Dermatol

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ImportanceThere are limited prognostic statistics and data available on survival outcomes for patients with mycosis fungoides (MF) in Asia.ObjectiveTo determine the prognostic factors and survival outcomes of patients with MF among a cohort in China.Design, Setting, and ParticipantsThis was a retrospective cohort study of patients with MF who received treatment at a tertiary referral center for skin lymphoma (Peking University First Hospital, Beijing, China) from August 1, 2009, to August 31, 2021. Data were analyzed from September 1, 2021, to December 31, 2022.Main Outcomes and MeasuresOverall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS); for prognostic factors, hazard ratios (HRs), and adjusted HRs (aHRs; adjusted for sex, age, and overall TNMB [tumor, node, metastasis, blood] stage) determined using the Cox proportional hazards model.ResultsThe study cohort comprised 461 patients with MF (median [range] age at diagnosis, 46 [5-87] years; 275 [59.7%] men and 186 [40.3%] women; 461 [100%] Chinese). The overall 5-year rate was 82.2% for OS, 83.5% for DSS, and 79.6% for PFS. Stage-specific 5-year OS rates were 95.7% for stage IA, 93.2% for IB, 95.7% for IIA, 70.1% for IIB, 55.3% for III, and 23.6% for IV. Compared with a UK cohort, our Chinese cohort had a younger median age at diagnosis (46 years vs 54 years) and a more favorable 5-year OS (82.2% vs 75.0%); however, after adjusting for age, the discrepancy in the 5-year OS rate was diminished (77.3% vs 76.4%). Cox models revealed that unfavorable predictors of OS, PFS, and DSS, respectively, were: age older than 60 years (aHR [95% CI], 2.25 [1.28-3.96]; 2.09 [1.16-3.76]; 2.27 [1.39-3.72]); advanced TNMB stage; advanced overall stage; large-cell transformation (aHR [95% CI], 2.16 [1.17-3.99]; 2.29 [1.21-4.33]; 2.21 [1.26-3.86]); and elevated lactate dehydrogenase levels (aHR [95% CI], 3.92 [1.64-9.36]; 4.77 [1.86-12.22]; 5.05 [2.23-11.42]). Biological sex and plaque lesion type were not associated with prognosis among this study cohort.Conclusion and RelevanceThe findings of this retrospective cohort study of patients with MF in China suggest that Asian patients are diagnosed at a younger age and have a higher 5-year OS compared with patients of other races in studies in other countries (predominantly White). Prognostic factors were similar to those of previous studies, except for patient sex and plaque lesion type.

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