Clinical characteristics of recurrent pneumonia in children with or without underlying diseases

Chen, Li-Lun; Liu, Yun-Chung; Lin, Hsiao-Chi; Hsing, Tzu-Yun; Liu, Yucheng; Yen, Ting‐Yu; Lu, Chun‐Yi; Chen, Jong-Min; Lee, Ping–Ing; Huang, Li‐Min; Lai, Feipei; Chang, Luan‐Yin

doi:10.1016/j.jfma.2021.08.013

Cited by 3 publications

(8 citation statements)

References 22 publications

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“…Underlying diseases were previously identified in 69%-92.4% of children with RP in different settings, which was similar to our results. [4][5][6][7][8][9][10][11]13 In accordance with most of these studies, we identified recurrent aspiration as the most common underlying condition. However, we found a higher prevalence of PID, BPD, and PCD and a lower prevalence of aspiration and asthma, compared with data from a study performed 20 years ago at a tertiary care pediatric hospital in Canada.…”

Section: Discussionsupporting

confidence: 79%

“…Among 551 patients, 90.6% were younger than 6 years of age; 66.4% were male; and 18.6% were born premature. The median age at first episode of pneumonia was 5 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) months, and the median age at diagnosis of RP was 14 (8-37) months (Table 1). Overall, 483 (87.7%) patients were identified as having at least one underlying disorder, and the proportions of prematurity and low birth weight were significantly higher in patients with underlying diseases.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Recurrent pneumonia (RP) is defined as two episodes of pneumonia in 1 year or three episodes over any timeframe 3 . RP occurs in 8%–11% of children with pneumonia, and it may lead to severe respiratory sequelae such as bronchiectasis 4–8 …”

Section: Introductionmentioning

confidence: 99%

“…A limited number of studies indicated that underlying diseases were identified in 69%–92% of patients with RP, including recurrent aspiration, immunodeficiency, and congenital heart disease (CHD); and distinct variations were found across studies with respect to the prevalence of the most common causes. In addition, these aforementioned studies largely focused on the distribution of the underlying diseases, with few comprising detailed clinical characteristics and clinical outcomes 4–11 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, these aforementioned studies largely focused on the distribution of the underlying diseases, with few comprising detailed clinical characteristics and clinical outcomes. [4][5][6][7][8][9][10][11] A recent study from Italy showed that the most common underlying conditions in children with RP were genetic diseases, including primary immunodeficiency (PID), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). 11 For children with genetic diseases, early diagnosis is crucial to reduce morbidity and to improve prognosis.…”

mentioning

confidence: 99%

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Underlying causes and outcomes of recurrent pneumonia in hospitalized children

Mei

Dai

Guo

et al. 2023

Pediatric Pulmonology

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Objectives: To describe the clinical characteristics and underlying causes of recurrent pneumonia (RP) among hospitalized children, and to identify risk factors associated with adverse outcomes. Methods:We reviewed the medical records of hospitalized children diagnosed with RP at the Children's Hospital of Fudan University from January 2016 to January 2021 and then described clinical characteristics and underlying causes. The associations between factors and adverse outcomes were assessed using logistic regression.Results: Of 551 children with RP, 483 (87.7%) manifested underlying causes, with recurrent aspiration (127, 23.0%), primary immunodeficiency (PID) (91, 16.5%), and congenital heart diseases (63, 11.4%) being the most common. Genetic defects were identified in about a quarter (158, 28.7%) of the patients. PID odds ratio (OR, 7.9; 95% confidence interval [CI], 2.8-22.8), primary ciliary dyskinesia (OR, 12.9; 95% CI, 3.0-54.8), bronchiolitis obliterans (OR, 7.0; 95% CI, 1.7-28.5), and a diagnosis of RP at an age of >3 years (OR, 3.4; 95% CI, 1.3-9.0) were risk factors for severe outcomes. Aspiration (OR, 2.9; 95% CI, 1.3-6.3) and an abnormal family history (OR, 3.3; 95% CI, 1.3-8.2) were risk factors for rehospitalization. Conclusions:The majority (87.7%) of hospitalized children with RP exhibited underlying causes, and genetic defects were common.

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Section: Discussionsupporting

confidence: 79%

Section: Patient Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Underlying causes and outcomes of recurrent pneumonia in hospitalized children

Mei

Dai

Guo

et al. 2023

Pediatric Pulmonology

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Highlights

Kao¹

2022

Journal of the Formosan Medical Association

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Clinical characteristics of persistent or recurrent pneumonia combined with airway malacia in children

Li,

Zhang,

Sun

et al. 2024

Clinical Respiratory J

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ObjectiveThe aim of this study is to investigate the clinical characteristics and pathogens involved in persistent or recurrent pneumonia combined with airway malacia in children.MethodsWe retrospectively reviewed the information of children hospitalised with persistent or recurrent pneumonia, including clinical presentations, laboratory examination results and pathogens.ResultsA total of 554 patients were admitted, 285 (51.44%) of whom were found to have airway malacia. There were 78 (27.37%), 166 (58.25%) and 41 (14.39%) patients with mild, moderate and severe malacia, respectively. Patients with airway malacia were younger than those without malacia (6.0 vs. 12.0 months, p < 0.01) and were more likely to present with wheezing (75.07%), fever (34.39%), dyspnoea (28.77%), cyanosis (13.68%) and wheezing in the lungs (78.95%). The incidence of preterm delivery, oxygen therapy, paediatric intensive care unit (PICU) admission and mechanical ventilation was higher, and the hospital stay (11.0 vs. 10.0 days, p = 0.04) was longer in these patients than in those without malacia. Patients with severe airway malacia were more likely to undergo oxygen therapy, PICU admission, mechanical ventilation and have multiple malacia than were those with mild or moderate malacia. Mycoplasma pneumoniae (30.18%) was the most common pathogen.ConclusionSevere airway malacia likely aggravates conditions combined with pneumonia. The proportion of multisite malacia was greater in severe airway malacia patients.

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Clinical characteristics of recurrent pneumonia in children with or without underlying diseases

Cited by 3 publications

References 22 publications

Underlying causes and outcomes of recurrent pneumonia in hospitalized children

Underlying causes and outcomes of recurrent pneumonia in hospitalized children

Highlights

Clinical characteristics of persistent or recurrent pneumonia combined with airway malacia in children

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