Clinical characteristics of scleroderma overlap syndromes: comparisons with pure scleroderma

Foocharoen, Chingching; Netwijitpan, Sittichai; Mahakkanukrauh, Ajanee; Suwannaroj, Siraphop; Nanagara, Ratanavadee

doi:10.1111/1756-185x.12884

Cited by 24 publications

(29 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LN is a common renal pathology in our SSc patients (46.2%) which reflects that the patients were SSc overlap SLE. The prevalence of SSc-SLE overlap was much higher than prior studies (6.8%, Alharbi et al and 16%, Foocharoen et al) 17,38. Among these patients, 50% were diagnosed SSc overlap SLE before performing kidney biopsy.…”

Section: Discussionmentioning

confidence: 59%

“…The diagnosis of scleroderma was based on the 1980 American College of Rheumatology (ACR) criteria20 and/or 2013 ACR/European League Against Rheumatism (EULAR) classification 21. Scleroderma was classified as either lcSSc or dcSSc subset as per the classification created by LeRoy et al22 The definition of SSc overlap syndrome was met when the patient fulfilled the criteria for scleroderma and they had the clinical features or specific autoantibodies of a connective tissue disease 17,23,24…”

Section: Methodsmentioning

confidence: 99%

“…In Thailand, the prevalence of renal involvement in dSSc was approximately 4% and SSc overlap with other connective tissue disease was 17% of which SSc-systemic lupus erythematosus (SLE) overlap syndrome was the second most common type (16%) 16,17. Renal involvement in SSc and SSc-SLE overlap syndrome has been reported in Thai SSc 17,18. However, the renal pathologic finding in SSc is limited.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Renal pathology and clinical associations in systemic sclerosis: a historical cohort study</p>

Tonsawan¹,

Talabthong²,

Puapairoj³

et al. 2019

IJGM

Self Cite

View full text Add to dashboard Cite

Background The information guiding the treatment decision(s) for renal diseases in systemic sclerosis (SSc) is the renal pathological finding. This study aimed to evaluate the renal pathological diagnosis and its clinical feature among SSc. Method A historical cohort study was performed on adult Thai SSc patients who underwent renal biopsy during January 2005–December 2016. The renal pathologic findings and patient clinical characteristics were reviewed. Chi-square or Fisher’s exact test was applied to analyze the association between clinical manifestation and renal pathology. Results Of the 26 SSc patients identified (77% female), 46% had the diffuse cutaneous SSc subtype. The mean age at the time of biopsy was 53.2±14.4 years and median duration of disease was 2.4 years (IQR 0.5–7.0). Rapidly progressive glomerulonephritis (RPGN) was the most common renal manifestation (53.9%) followed by nephrotic syndrome (19.2%) and nephritis (11.5%). The pathological diagnosis included lupus nephritis (LN) class IV (26.9%), LN class V (19.2%), scleroderma renal crisis (SRC; 19.3%), progressive renal disease in scleroderma (7.7%), and IgA nephropathy (7.7%). The nephrotic syndrome was the most common renal feature among LN class V patients, whereas RPGN was the commonest renal presentation among LN class IV and SRC patients ( p =0.001). Dialysis treatment at the time of kidney biopsy was significantly higher in SRC patients than in the other groups ( p <0.001). The SRC tended to have more frequent cardiac involvement, pulmonary fibrosis, and shorter disease duration than the other groups. Conclusion This is the first report of renal pathologic findings in Thai SSc patients. RPGN is the commonest renal manifestation among SSc who underwent kidney biopsy; for whom LN was the most common pathological finding. Nephrotic syndrome is a clinical feature of glomerular diseases other than renal involvement in SSc.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Renal pathology and clinical associations in systemic sclerosis: a historical cohort study</p>

Tonsawan¹,

Talabthong²,

Puapairoj³

et al. 2019

IJGM

Self Cite

View full text Add to dashboard Cite

show abstract

“…cechami nazwano "czerwonymi flagami" i zaliczono do objawów wczesnej SSc (very early diagnosis of SSc -VEDOSS) [8,9]. Wstępne wyniki prospektywnego badania VEDOSS wykazały, że dodatnia wartość predykcyjna dla SSc u chorych [16,17].…”

Section: Streszczenieunclassified

“…Granica stwardnień do stawu łokciowego lub kolanowego kwalifikuje chorobę jako ograniczoną (lcSSc). Należy zauważyć, że ok. 20% chorych na lcSSc może mieć cechy SSc jako jeden z elementów zespołu nakładania [16,17].…”

Section: Streszczenieunclassified

Systemic sclerosis – diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1: diagnosis and monitoring

Krasowska¹,

Rudnicka²,

Dańczak‐Pazdrowska³

et al. 2017

View full text Add to dashboard Cite

Prevalence and Characteristics of Patients With Systemic Sclerosis Fulfilling the 2019 EULAR/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

Bass,

Moore,

Steen

2023

Arthritis Care & Research

View full text Add to dashboard Cite

ObjectiveThere is limited literature describing the overlap of systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), and the studies have employed a range of case definitions. Our study used the new EULAR/ACR SLE classification criteria to define SSc‐SLE cases among our center's SSc cohort.MethodsThis is a single‐center, retrospective study of a previously described cohort of SSc patients. Patient data were re‐abstracted to evaluate for fulfillment of the 2019 EULAR/ACR classification criteria for SLE. Demographic, laboratory, clinical features, and mortality were compared among SSc‐SLE patients and patients with SSc‐alone.ResultsAmong the 402 patients with SSc that were analyzed, 40 (10%) fulfilled the 2019 EULAR/ACR SLE criteria. Neuropsychiatric and renal involvement were rare. An initial SLE diagnosis was purported in 43% of the SSc‐SLE patients and 7% of SSc‐alone patients (p < 0.001). SSc‐SLE patients were more likely to be female, African American, and with limited cutaneous SSc. Anti‐U1RNP antibody positivity prevalence was 30% among SSc‐SLE patients and 6.6% among SSc‐alone patients (p < 0.001). Death during follow‐up occurred in 12 (30%) of SSc‐SLE patients and in 81 (22%) of SSc‐alone patients, but there was no difference in survival among the groups per log rank test (p = 0.404).Conclusion10% of SSc patients fulfill the 2019 EULAR/ACR Classification Criteria for SLE. These patients comprise a distinct demographic, serologic, and clinical phenotype but have similar severe SSc‐specific end‐organ damage and mortality as SSc‐alone patients. SLE patients with Raynaud's should be evaluated for SSc‐specific autoantibodies and scleroderma organ involvement.This article is protected by copyright. All rights reserved.

show abstract

Clinical characteristics of scleroderma overlap syndromes: comparisons with pure scleroderma

Abstract: SOV rather than pure scleroderma presented in younger Thai scleroderma patients and SOV-PM was the most common subtype and its clinical features were similar to those of pure scleroderma. ATA was strongly associated with the latter.

Cited by 24 publications

References 31 publications

<p>Renal pathology and clinical associations in systemic sclerosis: a historical cohort study</p>

<p>Renal pathology and clinical associations in systemic sclerosis: a historical cohort study</p>

Systemic sclerosis – diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1: diagnosis and monitoring

Prevalence and Characteristics of Patients With Systemic Sclerosis Fulfilling the 2019 EULAR/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

Contact Info

Product

Resources

About