Clinical characteristics of testicular extramedullary involvement in multiple myeloma

Mohan, Meera; Yarlagadda, Naveen; Szabó, Anikó; Singh, Amrit Pal; Piña‐Oviedo, Sergio; Schinke, Carolina

doi:10.1002/ajh.26072

Cited by 2 publications

(5 citation statements)

References 17 publications

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“…EMM is historically known to bear a worse prognosis compared to marrow-restricted myeloma[ 13 ]. Several studies have been carried out to investigate clinical characteristics and prognostic factors of EMM[ 4 - 8 , 12 ]. However, there is a paucity of data investigating the interaction of age and gender in regard to the mortality of EMM.…”

Section: Discussionmentioning

confidence: 99%

“…Optical mapping showed the potential for refining the complex genomic architecture in MM and its phenotypes[ 3 ]. Only few studies in the literature have addressed the clinical characteristics of patients with EMM[ 4 - 8 ]. Age at the diagnosis of MM and the site of extramedullary disease have been shown to be independent prognostic factors[ 4 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Only few studies in the literature have addressed the clinical characteristics of patients with EMM[ 4 - 8 ]. Age at the diagnosis of MM and the site of extramedullary disease have been shown to be independent prognostic factors[ 4 , 9 ]. Furthermore, there is some data associating the male gender with MM[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades

Bangolo¹,

Fwelo²,

Trivedi³

et al. 2023

World J Clin Oncol

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BACKGROUND Extramedullary multiple myeloma (MM) (EMM) is a rare and aggressive subentity of MM that can be present at diagnosis or develop anytime during the disease course. There is a paucity of data on the clinical characteristics and overall epidemiology of EMM. Furthermore, there is a scarcity of data on how the interaction of age and gender influences the survival of EMM. AIM To evaluate the clinical characteristics of patients with EMM over the past 2 decades and to identify epidemiologic characteristics that may impact overall prognosis. METHODS A total of 858 patients diagnosed with EMM, between 2000 and 2017, were ultimately enrolled in our study by retrieving the Surveillance, Epidemiology, and End Results database. We analyzed demographics, clinical characteristics, and overall mortality (OM) as well as cancer-specific mortality (CSM) of EMM. Variables with a P value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors, with a hazard ratio (HR) of greater than 1 representing adverse prognostic factors. RESULTS From a sample of 858 EMM, the male gender (63.25%), age range 60-79 years (51.05%), and non-Hispanic whites (66.78%) were the most represented. Central Nervous System and the vertebral column was the most affected site (33.10%). Crude analysis revealed higher OM in the age group 80+ [HR = 6.951, 95% confidence interval (95%CI): 3.299-14.647, P = 0], Non-Hispanic Black population (HR = 1.339, 95%CI: 1.02-1.759, P = 0.036), Bones not otherwise specified (NOS) (HR = 1.74, 95%CI: 1.043-2.902, P = 0.034), and widowed individuals (HR = 2.107, 95%CI: 1.511-2.938, P = 0). Skin involvement (HR = 0.241, 95%CI: 0.06-0.974, P = 0.046) and a yearly income of $75000+ (HR = 0.259, 95%CI: 0.125-0.538, P = 0) had the lowest OM in the crude analysis. Crude analysis revealed higher CSM in the age group 80+, Non-Hispanic Black, Bones NOS, and widowed. Multivariate cox proportional hazard regression analyses only revealed higher OM in the age group 80+ (HR = 9.792, 95%CI: 4.403-21.774, P = 0) and widowed individuals (HR = 1.609, 95%CI: 1.101-2.35, P = 0.014). Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups. Eyes, mouth, and ENT involvement had the lowest CSM in the multivariate analysis. There was no interaction between age and gender in the adjusted analysis for OM and CSM. CONCLUSION EMM is a rare entity. To our knowledge, there is a scarcity of data on the clinical characteristics and prognosis factors of patients with extramedullary multiple myeloma. In this retrospective cohort, using a United St...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades

Bangolo¹,

Fwelo²,

Trivedi³

et al. 2023

World J Clin Oncol

View full text Add to dashboard Cite

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“…However, data are still very limited, and therefore the optimal therapy management and the importance of orchiectomy or local radiation are still unclear. [4][5][6] To the authors' knowledge, so far only 3 cases with bilateral synchronous testicular manifestation in multiple myeloma have been described. 7,8…”

Section: Figurementioning

confidence: 99%

“…Although extramedullary manifestations are detected more frequently, testicular manifestation is associated with poor survival rates (median overall survival, 19.6 months). However, data are still very limited, and therefore the optimal therapy management and the importance of orchiectomy or local radiation are still unclear 4–6 . To the authors’ knowledge, so far only 3 cases with bilateral synchronous testicular manifestation in multiple myeloma have been described 7,8 …”

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confidence: 99%

Unusual Extramedullary Manifestation in Multiple Myeloma

et al. 2022

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A 73-year-old man with multiple myeloma (initial diagnosis 21 months earlier) was referred to our center for a whole-body 18 F-FDG PET/CT. We detected a bilateral synchronous testicular manifestation, which was confirmed by histopathology after orchiectomy. Besides hypermetabolic lesions in the spine and ribs (most likely old fractures), known osteolysis showed no uptake. Extramedullary manifestation occurs in 13% to 20% of cases, among these 4% demonstrate testicular manifestation, which is associated with poor survival rates. Optimal therapy management is still unclear, due to limited data. To the authors' knowledge, so far only 3 comparable cases have been described.

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Clinical characteristics of testicular extramedullary involvement in multiple myeloma

Abstract: survival outweighs the negative long-term effects of HCT. Our findings underline the necessity of long-term follow-up after allo-HCT that facilitates early detection of late morbidities, and targeted lifestyle and medical interventions regardless of which conditioningregimen is used.

Cited by 2 publications

References 17 publications

Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades

Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades

Unusual Extramedullary Manifestation in Multiple Myeloma

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