Clinical Characteristics of Vitamin a Responsive and Nonresponsive Bitot's Spots

Sommer, Alfred; Emran, Nani; Sugana, Tjakrasudjatma

doi:10.1016/s0002-9394(14)74848-2

Cited by 49 publications

(11 citation statements)

References 12 publications

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“…Three subjects had abnormal (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) 4_IJ_0.52 (14.9)_0.14 (4.1)_0.28-0.84 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) 5_4_0.39 (11.2)_0.13 (3.6)_0.28-0.56 (8)(9)(10)(11)(12)(13)(14)(15)(16) *P< .002 for monotonically decreasing trend. 3_24_0.54 (15.4)_0.14 (3.9)_0.31-0.80 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)…”

Section: Response To Vitamin Amentioning

confidence: 99%

“…This variation is consistent with that noted in previous clinical studies describing patients with conjunctival xerosis or Bitot's spots requiring two weeks to more than two months to return to nor¬ mal. 24 Thus, impression cytology detects early, physiologically significant vita¬ min A deficiency. The technique is well suited for population surveys to determine a community's vitamin A status.…”

Section: Response To Vitamin Amentioning

confidence: 99%

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Impression Cytology for Detection of Vitamin A Deficiency

Natadisastra¹,

Wittpenn

West³

et al. 1987

Archives of Ophthalmology

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Section: Response To Vitamin Amentioning

confidence: 99%

Section: Response To Vitamin Amentioning

confidence: 99%

Impression Cytology for Detection of Vitamin A Deficiency

Natadisastra¹,

Wittpenn

West³

et al. 1987

Archives of Ophthalmology

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“…Night blindness will disappear within 1-3 days, while conjunctival xerosis and Bitot's spots are generally gone within 1-3 weeks (in older children these will often shrink, but wax and wane despite adequate vitamin A nutriture, for years to come [13]). Corneal xerosis follows a similar course.…”

mentioning

confidence: 99%

Xerophthalmia, keratomalacia and nutritional blindness

Sommer¹

1990

Int Ophthalmol

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Vitamin A deficiency remains a major cause of pediatric ocular morbidity. Over five million children develop xerophthalmia annually, a quarter million or more becoming blind. It is also a major pathway for measles-associated blindness, particularly in Africa. Treatment is practical and inexpensive, based upon the oral administration of 200,000 IU vitamin A on two successive days, at a cost of 10 cents U.S. Given the potential rapidity of corneal necrosis (keratomalacia) and the relative inaccessibility of health services to those at greatest risk, prevention is probably more important than treatment. Oral administration of high dose supplements (2000,000 IU every 3 to 6 months), vitamin A fortification of commonly consumed items, or best of all, increased dietary intake of natural sources of vitamin A will reduce the number of needlessly blind young children. Given recent evidence that vitamin A deficiency greatly increases overall mortality, even among children without evidence of xerophthalmia, the same prophylactic regimen may improve child survival by 35% or more.

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“…However in the tropics it is assumed that when xerosis occurs bilaterally and temporal and nasal to the limbus active vitamin A deficiency is involved [14].…”

Section: Discussionmentioning

confidence: 99%

Conjunctival xerosis, arcus lipoides and Rieger's disease

Keizer

1991

Doc Ophthalmol

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Three generations of a family with conjunctival xerosis, Rieger's anomaly (complete or incomplete) and arcus lipoides are described. The xerosis was found always to be accompanied by a Rieger anomaly, which had sometimes, but not always, been detected before. Independent heredity was not observed. In a number of cases the xerosis was bilateral and localised both temporally and nasally. The combination appears to be a stigma malformationis oculi. Correlation with a temporary vitamin A deficiency in early youth appears possible. At this age in such families caution is advisable in the administration of vitamin A inhibiting medicines such as steroids and neomycine.

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Clinical Characteristics of Vitamin a Responsive and Nonresponsive Bitot's Spots

Cited by 49 publications

References 12 publications

Impression Cytology for Detection of Vitamin A Deficiency

Impression Cytology for Detection of Vitamin A Deficiency

Xerophthalmia, keratomalacia and nutritional blindness

Conjunctival xerosis, arcus lipoides and Rieger's disease

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