Clinical characteristics, outcome and early induction deaths in patients with acute promyelocytic leukaemia: a five-year experience at a tertiary care centre

Acute Promyelocytic Leukemia: a Single Center Study from Southern Pakistan

“…Karim et al from Pakistan recently reported 73% of patients have shown specific t(15;17) (Karim et al, 2014). Analogous to our study, Spanish and Chinese studies have also reported 74% and 75.9% of patients had standard translocation t(15;17) (Liang et al, 2008;Montesinos et al, 2011).…”

“…The principal APL epidemiological features so far described show no gender predilection in more studies (Karim et al, 2014). However we determined the female gender dominance, which was also seen in Malaysian APL patients (Ambayya et al, 2014).…”

“…Previously, a study conducted in Pakistan has reported a median age of 41 years, which is a bit high as compared with our findings. This difference might be the reflection of the fact that prior study was conducted exclusively on adult's patients (Karim et al, 2014). However large regional studies reported from China have shown the median age of 33 and 40 years respectively (Liang et al, 2008;Lou et al, 2015).…”

“…Morphologically there are two variants of APL, commonest one is hypergranular variant while microgranular variant is accountable in 25% of cases but is more aggressive than the hypergranular type (Karim et al, 2014). The microgranular variant is also associated with a higher risk of early haemorrhagic death.…”

Rare labial ulcer related to the use of all‐trans retinoic acid in a patient with acute promyelocytic leukemia

“…The incidence of RAS is uncertain, with rates ranging from 2% to 27%. The mortality rate related to this disease generally ranges from 1% to 14%, but rates as high as 100% have been reported …”