Clinical characteristics, rates of blindness, and geographic features of PACD in China

Zhang, Hui; Cao, Kai; Jia, Hongyan; Li, Liang; Hu, Jianping; Liang, Jing; Song, Jing; Huī, Wánɡ; Zhao, Aiping; Duan, Xiaoming; Fan, Sujie; Wang, Feng; Su, Ying; Ha, Shaoping; Duan, Xuanchu; Yu, Jin; Zhao, Chunjiang; Tang, Guangxian; Su, Yufang; Cai, Hongying; Gao, Jiwei; Qu, Yanbing; Lü, Peng; Xie, Xiaobin; Zhao, Junhong; Tang, Li; Liu, Danyan; Liu, Wei; Zhang, Min; Fang, Aiwu; Dai, Weijia; Zhong, Hua; Zhang, Xueling; Wu, Zuohong; Zhai, Gang; Lyu, Hongbin; Xie, Lin; Li, Haijun; Zheng, Yajuan; Li, Ning; Li, Kaijun; Xie, Guobo; Qu, Hongbo; Yu, Jun; Liang, Liang; Zhu, Min; Wang, Xuemei; Ma, Xiao; Zeng, Liuzhi; Liu, Xuyang; Zhang, Yong; Zhang, Yuyan; Yu, Fuxiang; Chen, Jinyuan; Cheng, Sumian; Yu, Man; Li, Jingmin; Zhang, Yinong; Liu, Ping; Wu, Zhihong; Zhang, Xiuzhi; Kuo, Debbie S.; Wang, Ke; Qiao, Chunyan

doi:10.1016/j.jcjo.2020.12.010

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…It is suggested that female patients with a shallow ACD may be more likely to develop acute primary angle-closure glaucoma than male patients based on cataract impacts. This is consistent with the finding of an epidemiological study that the incidence rate among females is higher than that in males [35] . Similarly, Uyghur patients are more likely to develop acute primary angle-closure glaucoma than Han patients.…”

Section: Ocular Biometric Characteristics Of Ethnic Groupssupporting

confidence: 93%

Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery

Xu,

Feng,

Zhang

et al. 2024

Int J Ophthalmol

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AIM: To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery. METHODS: In this hospital-based prospective study, 410 patients undergoing cataract surgery (226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang) were enrolled. The differences in axial length (AL), anterior chamber depth (ACD), keratometry [steep K (Ks) and flat K (Kf)], and corneal astigmatism (CA) measured using IOL Master 700 were compared between Han and Uyghur patients. RESULTS: The average age of Han patients was higher than that of Uyghur patients (70.22±8.54 vs 63.04±9.56y, P<0.001). After adjusting for age factors, Han patients had longer AL (23.51±1.05 vs 22.86±0.92 mm, P<0.001), deeper ACD (3.06±0.44 vs 2.97±0.37 mm, P=0.001), greater Kf (43.95±1.40 vs 43.42±1.69 D, P=0.001), steeper Ks (45.00±1.47 vs 44.26±1.71 D, P=0.001), and higher CA (1.04±0.68 vs 0.79±0.65, P=0.025) than Uyghur patients. Intra-ethnic male patients had longer AL, deeper ACD, and lower keratometry than female patients; however, CA between the sexes was almost similar. In the correlation analysis, we observed a positive correlation between AL and ACD in patients of both ethnicities (rHan=0.48, rUyghur=0.44, P<0.001), while AL was negatively correlated with Kf (rHan=-0.42, rUyghur=-0.64, P<0.001) and Ks (rHan= -0.38, rUyghur=-0.66, P<0.001). Additionally, Kf was positively correlated with Ks (rHan=0.89, rUyghur=0.93, P<0.001). CONCLUSION: There are differences in ocular biometric parameters between individuals of Han ethnicity in Tianjin and those of Uyghur ethnicity in Xinjiang undergoing cataract surgery. These ethnic variances can enhance our understanding of ocular diseases related to these parameters and provide guidance for surgical procedures.

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Section: Ocular Biometric Characteristics Of Ethnic Groupssupporting

confidence: 93%

Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery

Xu,

Feng,

Zhang

et al. 2024

Int J Ophthalmol

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“…Compared with traditional GC-MS [22][23][24][25], GC×GC-TOFMS had a better separation ability that was used to solved the problems of co-elution of components, and provided more comprehensive and high-quality information for the complex aroma components. It was seen from Fig.…”

Section: Results Of Portable Gc-msmentioning

confidence: 99%

The portable GC-MS and HS/SPME-GC×GC-TOF MS-Based Analysis of the Difference of Citri Grandis Exocarpium from Different Regions

Huang,

Zhou,

et al. 2023

Preprint

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In this study, the portable GC-MS and comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF MS) combined with headspace solid-phase microextraction (HS/SPME) combined with chemometric were firstly used to analyze the volatile components of Citri Grandis Exocarpium that were from Huazhou (CGEH) and Guangxi (CGEG), respectively. The results from portable GC-MS only can identified some differences between samples. Compared with results from HS/SPME-GC×GC-TOF MS we found that portable GC-MS could not analyze the mark of CGEH.From identification of GC×GC-TOF MS we got that total 304 chemicals among which 261 were firstly reported were identified. Among them 52 compounds were only detected in CGEH, 81 were unique in CGEG and 171 were in both CGEH and CGEG. The volatile components in CGEH were classified into 17 and CGEG into 19 types. The contents of alkene aromatics, hydrocarbons and alcohols in both CGEH and CGEG were relatively high. These results fully demonstrated the detection ability of GC×GC-TOF MS. Principal Component Analysis (PCA) and Orthogonal Partial Least Squares (OPLS-DA) were performed. The results indicated that there was basically no difference from different batches of the same origin. However, there were obvious differences between CGEH and CGEG. 10 compounds in CGEH were screened out the values of |p(corr)|>0.9, |p|>0.06 and VIP value > 1.1. These results proved portable GC-MS could not find marks of Citri Grandis Exocarpium and GC×GC-TOF MS could find it.

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“…1 Primary angle closure disease (PACD) is the major group of glaucoma-related conditions in China. 2 PACD is usually classified into primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and acute angle closure (AAC). 3,4 Among all the subtypes, AAC is the most severe visually impairing condition.…”

mentioning

confidence: 99%

“…3,4 Among all the subtypes, AAC is the most severe visually impairing condition. 2,5 Previous studies have demonstrated that short axial length (AL), shallow anterior chamber, thick lens, and relative anterior lens position can lead to "crowding" of the anterior chamber angle, resulting in angle closure and subsequential elevation of IOP. 6,7 The European guidelines for glaucoma suggest that lens abnormality could be a possible cause of angle closure in these cases.…”

mentioning

confidence: 99%

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Zonulopathy Identified During Cataract Extraction in Patients With Primary Angle Closure Disease

Zhang

et al. 2023

Journal of Glaucoma

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Précis: The proportion, clinical characteristics, and risk factors of zonulopathy in primary angle closure disease (PACD) were analyzed. Zonulopathy is an underrecognized common finding in PACD, especially in patients with acute angle closure (AAC).Purpose: To examine the proportion and risk factors associated with intraoperative zonulopathy in PACD.Patients and Methods: This is a retrospective analysis of 88 consecutive patients with PACD who underwent bilateral cataract extraction at Beijing Tongren Hospital from August 1, 2020 to August 1, 2022. Zonulopathy was diagnosed based on intraoperative findings including the presence of a lens equator, radial folds of the anterior capsule while making capsulorhexis, and other signs of the unstable capsular bag. The subjects were grouped based on their PACD subtype diagnoses: AAC, primary angle closure glaucoma (PACG), primary angle closure (PAC), or primary angle closure suspect (PACS). Multivariate logistic regression was performed to identify risk factors associated with zonulopathy. The proportion and the risk factors of zonulopathy were estimated in patients with PACD and in PACD subtypes.Results: Of 88 patients with PACD (67.3 ± 6.9 y old, 19 males and 69 females), the overall proportion of zonulopathy was 45.5% of patients (40/88) and 30.1% of eyes (53/176). Among the PACD subtypes, the proportion of zonulopathy was highest (69.0%) in AAC, followed by 39.1% in PACG, and 15.3% in PAC and PACS combined. AAC was an independent risk factor associated with zonulopathy (P = 0.015, AAC vs PACG, PAC, and PACS combined; odds ratio: 0.340, CI: 0.142 -0.814). Shallower anterior chamber depth (P = 0.031) and greater lens thickness (P = 0.036), but not laser iridotomy, were associated with an increased proportion of zonulopathy.Conclusions: Zonulopathy is common in PACD, especially in patients with AAC. Shallow anterior chamber depth and thick lens thickness were associated with an increased proportion of zonulopathy.

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Clinical characteristics, rates of blindness, and geographic features of PACD in China

Cited by 5 publications

References 36 publications

Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery

Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery

The portable GC-MS and HS/SPME-GC×GC-TOF MS-Based Analysis of the Difference of Citri Grandis Exocarpium from Different Regions

Zonulopathy Identified During Cataract Extraction in Patients With Primary Angle Closure Disease

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