Clinical characteristics, surgical strategies, and outcome of solid pseudopapillary tumor of the pancreas: retrospective analysis in a single center.

Zhang, Weigang; Qiu, Junyi; Bian, Wuyang; Sun, Dihua; Shi, Yang; Qin, Lei; Xue, Xiaofeng

doi:10.5114/wiitm.2021.108804

Cited by 2 publications

(1 citation statement)

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“…Solid pseudopapillary neoplasm can occur in all parts of the pancreas, mostly, in the body and tail of the pancreas ( 14 ). Of the 18 cases in this group, 11 occurred in the body and tail of the pancreas, accounting for 61.11%.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases

Maimaijiang

Wang

et al. 2022

Front. Pediatr.

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PurposeTo explore the incidence, imaging and treatment of solid pseudopapillary tumor of pancreas in children, and Summarize the experience of treatment.MethodsThe clinical data of 18 children with a solid pseudopapillary tumor of the pancreas treated in our hospital from January 2012 to June 2021 were analyzed retrospectively. The age range was 8–16 years old, the average age was 11.67 years old, and the median age was 11.5 years old, namely, three boys with an average age of 10 years old and 15 girls with an average age of 12 years old. In total, two cases were admitted to the hospital because of trauma, seven cases were found in physical examination, and nine cases were admitted with the abdominal pain as the main complaint. Enhanced CT examination was performed before operation, nuclear magnetic resonance examination and abdominal ultrasound examination were performed in some children, and plain CT scan was performed after operation.ResultsSolid pseudopapillary tumor of the pancreas can occur in all parts of the pancreas, especially in the body and tail of the pancreas. Among the 18 cases, SPN occurred in the head of pancreas in 5 cases (27.78%), the neck of pancreas in 2 cases (11.11%), and the body and tail of pancreas in 11 cases (61.11%). All the 18 children were treated by operation. among them, 4 cases underwent choledochal pancreatico duodenectomy (1 case), 4 cases underwent pancreaticoduodenectomy combined with splenectomy (3 cases), 6 cases underwent spleen-preserving pancreatectomy / tail pancreatectomy (1 case), 3 cases underwent enucleation of pancreatic tumor due to exogenous growth, 1 case underwent laparoscopic partial pancreatectomy and pancreaticoenterostomy. Laparotomy was performed in 12 cases and endoscopic surgery in 6 cases. Postoperative pathology confirmed solid pseudopapillary tumor of the pancreas. None of the patients received radiotherapy and chemotherapy after operation and were followed up for 6 months to 2 years. There was no recurrence, metastasis or pancreatic dysfunction.ConclusionSolid pseudopapillary tumor of pancreas in children is a rare, low-grade malignant solid tumor with no specific clinical manifestations and laboratory examinations. Preoperative diagnosis mainly depends on enhanced CT. Surgical resection of tumor is a reliable treatment, and the specific operation is mainly based on the experience of the chief surgeon, the location of the tumor and the invasion of surrounding tissue. At present, there is no evidence of the effectiveness of other treatment options, and surgical resection of the tumor has a good prognosis.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases

Maimaijiang

Wang

et al. 2022

Front. Pediatr.

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Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Xu,

Fu,

Yang

2024

World J Gastrointest Oncol

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Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm predominantly observed in young females. Pathologically, CTNNB1 mutations, β-catenin nuclear accumulation, and subsequent Wnt-signaling pathway activation are the leading molecular features. Accurate preoperative diagnosis often relies on imaging techniques and endoscopic biopsies. Surgical resection remains the mainstay treatment. Risk models, such as the Fudan Prognostic Index, show promise as predictive tools for assessing the prognosis of SPTP. Establishing three types of metachronous liver metastasis can be beneficial in tailoring individualized treatment and follow-up strategies. Despite advancements, challenges persist in understanding its etiology, establishing standardized treatments for unresectable or metastatic diseases, and developing a widely recognized grading system. This comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology, clinical presentation, pathology, molecular characteristics, diagnostic methods, treatment options, and prognostic factors.

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Clinical characteristics, surgical strategies, and outcome of solid pseudopapillary tumor of the pancreas: retrospective analysis in a single center.

Cited by 2 publications

References 32 publications

Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases

Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

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