Clinical Characteristics, Treatment and Ocular Complications of HLA-B27-Related Anterior Uveitis and HLA-B27-Non Related Anterior Uveitis

Pascual, Elia Valls; Ortega, Pablo Fontanilla; Bernabéu, E. Vicens; Martínez-Costa, L.; Alonso, Ricardo Blanco

doi:10.1016/j.reumae.2015.11.014

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Different geographical areas may explain part of the variation. Furthermore, our result that uveitis was independently related to HLA-B27 presence was in accordance with previous studies (27,28). In contrast, another previous study showed that in patients with uveitis and HLA-B27 presence, the risk of developing SpA is significantly higher than in uveitis patients without HLA-B27 (29).…”

Section: Discussionsupporting

confidence: 93%

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Zhang

Wang

et al. 2020

Front. Med.

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Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence.Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence.Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.

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Section: Discussionsupporting

confidence: 93%

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Zhang

Wang

et al. 2020

Front. Med.

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“…We found patients with AU to be more often male and HLA-B27 positive, thus, in this sense our data are in agreement with results previously reported suggesting AU to occur more commonly among male patients 24–26 and its presence to be related to HLA-B27. 20,27,28 We also observed an association between current/recent AU and lower disease activity assessed by BASDAI. This intriguing association might be indicative of a disconnection between ocular and musculoskeletal inflammation.…”

Section: Discussionsupporting

confidence: 61%

The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study

Redeker

Siegmund

Ghoreschi

et al. 2020

Therapeutic Advances in Musculoskeletal

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Objective: The aim of this study was to investigate the association of extra-musculoskeletal manifestations (EMMs) with disease activity, functional status, and treatment patterns in a large population-based cohort of patients with axial spondyloarthritis (axSpA). Methods: A stratified random sample of patients with axSpA, drawn from health insurance data, received a survey on disease-related characteristics including history (ever presence) of the following EMMs: inflammatory bowel disease (IBD), psoriasis (PSO), and anterior uveitis (AU). Survey data were linked to health insurance data, gathering additional information on current occurrence (within one year) of EMMs and drug prescriptions. Separate multivariable linear regression models were calculated to determine the association of EMMs with disease activity (Bath Ankylosing Spondylitis Disease Activity Index), and functional status (Bath Ankylosing Spondylitis Functional Index) after adjustment for relevant parameters, including treatment. Results: A total of 1729 patients with axSpA were included in the analyses (response: 47%; mean age: 56 years; 46% female) of whom 6% (9%) had current (ever) IBD, 10% (15%) had current (ever) PSO, and 9% (27%) had current (ever) AU. Ever presence of IBD and history of PSO were significantly associated with higher level of disease activity. Ever presence of PSO was also associated with higher level of functional impairment, whereas current AU was significantly associated with lower disease activity. Patients with current IBD or PSO received more frequently biological and conventional synthetic disease-modifying anti-rheumatic drugs as well as systemic steroids. AU was associated with a higher use of conventional synthetic disease-modifying anti-rheumatic drugs only. Conclusion: Disease activity is higher in patients with axSpA with history of IBD or history of PSO. Functional impairment is also higher in patients with axSpA with history of PSO. The presence of different EMMs was associated with different treatment patterns in axSpA.

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“…The finding of ASO elevation associated with a recent infection suggests that the targeting of the immune response secondary to infection may have a role in the etiology of uveitis [12]. Despite all these findings, HLA B27 positivity was found to be associated with uveitis regardless of other findings in AS patients [13]. In addition, approximately 20% of HLA B27 negative AS cases show at least 1 uveitis attack.…”

Section: Discussionmentioning

confidence: 99%

Frequency of uveitis and its associations with HLA B27 in ankylosing spondylitis patients

Demir

Devecı

Demir

2019

j-ebr

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To investigate the prevalence of uveitis in ankylosing spondylitis (AS) patients and its relationship with HLA B27. Methods: The data of 95 patients with AS who admitted to Tokat Gaziosmanpaşa University Internal Medicine and Rehabilitation Outpatient Clinics between 2010 and 2019 were analyzed retrospectively. Demographic characteristics, HLA B27 positivity and detailed eye consultation notes of the patients were recorded. Results: Of the 95 patients, 65 (68%) were male and 30 (32%) were female. The mean age of the patients was 38.3 ± 11.6 years. The HLA B27 results of 10 patients could not be reached. 22% of the patients had at least one episode of uveitis attack. While 82% (70/85) of patients had HLA B27 positivity, this rate was 86% in (18/21) patients with uveitis. Conclusion:Uveitis is a disease that can cause permanent loss of vision. In our study, no significant difference was found between the presence of uveitis and the presence of HLA B27 in patients with AS and this finding needs to be supported by randomized studies.

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Clinical Characteristics, Treatment and Ocular Complications of HLA-B27-Related Anterior Uveitis and HLA-B27-Non Related Anterior Uveitis

Cited by 7 publications

References 15 publications

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study

Frequency of uveitis and its associations with HLA B27 in ankylosing spondylitis patients

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