Clinical characteristics, treatment options, and prognosis of myeloid sarcoma: analysis using the SEER database

Liang, Jingjing; Yang, Liu; Yang, Bo; Tian, Yaru; Ren, Juan; Yang, Linhua

doi:10.1080/16078454.2023.2247898

Cited by 3 publications

(4 citation statements)

References 22 publications

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“… 8 , 9 Systemic chemotherapy was well tolerated in our patient who had multiple comorbidities including an active infection. While local therapy for MS remains controversial, a recent analysis of MS with and without bone marrow involvement from the SEER database found a survival benefit from the addition of local resection or radiation to systemic therapy for patients with isolated MS. 3 As exemplified by the present case, treatment should be customized to the individual.…”

Section: Discussionmentioning

confidence: 92%

“… 1 These lesions can be found in any location in the body, most commonly in connective tissues, skin, visceral organs, and lymph nodes. 2 , 3 MS usually occurs concurrently with intramedullary disease in acute myeloid leukemia (AML), but isolated MS constitutes approximately 1% of newly diagnosed acute myeloid neoplasms. 2 MS has also been reported to represent the return of disease after temporary remission, coincide with the blast phase of a chronic myeloid disorder, or even precede bone marrow involvement in AML.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myeloid sarcoma presenting as fingertip necrosis with underlying suppurative tenosynovitis: A case report

Bloomfield,

Finkel,

Mun’em Al Hourani

et al. 2024

Clinical Case Reports

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Myeloid sarcoma presenting as fingertip necrosis with underlying suppurative tenosynovitis: A case report

Bloomfield,

Finkel,

Mun’em Al Hourani

et al. 2024

Clinical Case Reports

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show abstract

“…Some studies have confirmed the efficacy of decitabine in the treatment of MS, reporting that it can induce long-term remission ( 4 , 24 ). In a Surveillance, Epidemiology and End Results database analysis, Liang et al ( 13 ) found that when using overall survival as an indicator of efficacy, patients with non-isolated MS showed an improved response to cytarabine-based AML chemotherapy regimens. It has also been reported that a patient with bladder MS with TP53 mutation achieved a significant improvement in symptoms and achieved complete CR in the first cycle of 20 mg decitabine treatment combined with induction chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…This is often abandoned due to bone marrow suppression and other side effects. If not treated in time, almost all patients may develop systemic disease and experience progression to acute leukemia ( 13 ). The present study describes, to the best of our knowledge, the first case of an elderly patient with lymph node MS combined with TP53 (V173G) mutation, who eventually died of respiratory failure due to refractory pneumonia after treatment with a variety of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report

Mao,

Deng

2024

Oncol Lett

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Myeloid sarcoma (MS) is a rare extramedullary tumor mass that carries a high risk of progression to acute myeloid leukemia (AML), and patients with MS are commonly treated with the AML regimen. However, MS is frequently misdiagnosed due to its lack of clinical specificity. Patients with MS who harbor tumor protein p53 (TP53) mutations and complex karyotypes are considered to have a poorer prognosis. The present study reports a case of lymph node MS with TP53 (V173G)-related myelodysplastic syndrome (MDS). The mass was first considered to be a lymphoma and treated as such. However, following immunohistochemical analysis, which revealed cells positive for CD43, myeloperoxidase and CD117, the patient was later diagnosed with MS combined with MDS. The patient went into complete remission after the first cycle of chemotherapy, and showed a decrease in platelet, red blood cell and white blood cell counts following the second cycle of chemotherapy. After the third chemotherapy, agranulocytosis occurred, leading to refractory pneumonia and eventually death due to respiratory failure. MS with TP53-related MDS has a low incidence rate, a poor prognosis and a short survival time. The clinical manifestations of MS are non-specific and easy to misdiagnose, leading to delayed diagnosis and treatment, and ultimately worsening the prognosis of the patients. Therefore, a lymph node biopsy should be performed as soon as possible for patients with lymph node enlargement, and early treatment should be carried out to prolong the survival period.

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Breast relapse of myeloid sarcoma and SARS-CoV-2 infection following hematopoietic stem cell transplantation in mixed-phenotype acute leukemia: a case report

Hu,

Liu,

Zhao

et al. 2024

Emerg Crit Care Med

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Background Mixed-phenotype acute leukemia is a rare, high-risk subtype of acute leukemia. Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside the bone marrow. It is often an extramedullary manifestation of acute myeloid leukemia, and imaging lacks specificity, leading to potential misdiagnosis. Case Presentation A female patient diagnosed with mixed-phenotype acute leukemia achieved complete remission after chemotherapy and allogeneic hematopoietic stem cell transplantation. However, a relapse occurred in the breast after transplantation. The patient achieved local control through mastectomy and removal of the axillary lymph nodes on the affected side. Unfortunately, during the subsequent course of chemotherapy, the patient died of a severe pulmonary infection caused by coronavirus disease 2019. Conclusion Continuous treatment and monitoring of mixed-phenotype acute leukemia patients are essential, especially for those with extramedullary manifestations (such as breast involvement).

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Clinical characteristics, treatment options, and prognosis of myeloid sarcoma: analysis using the SEER database

Cited by 3 publications

References 22 publications

Myeloid sarcoma presenting as fingertip necrosis with underlying suppurative tenosynovitis: A case report

Myeloid sarcoma presenting as fingertip necrosis with underlying suppurative tenosynovitis: A case report

Lymph node myeloid sarcoma with TP53‑associated myelodysplastic syndrome: A case report

Breast relapse of myeloid sarcoma and SARS-CoV-2 infection following hematopoietic stem cell transplantation in mixed-phenotype acute leukemia: a case report

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