Clinical comparison of low-volume agents (oral sulfate solution and sodium picosulfate with magnesium citrate) for bowel preparation: the EASE study

Abstract

Background/Aims This study compared the efficacy, compliance, and safety of bowel preparation between sodium picosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS). Methods A prospective randomized multicenter study was performed. Split preparation methods were performed in both groups; the SPMC group, 2 sachets on the day before, and 1 sachet on the day of the procedure, the OSS group, half of the OSS with 1 L of water on both the day before and the day of the procedure. The adenoma detection rate (ADR), adequacy of bowel preparation using the Boston Bowel Preparation Scale (BBPS) score, patient satisfaction on a visual analog scale (VAS), and safety were compared between the 2 groups. Results This study analyzed 229 patients (121 in the SPMC group and 108 in the OSS group). ADR showed no differences between 2 groups (51.7% vs. 41.7%, P >0.05). The mean total BBPS score (7.95 vs. 8.11, P >0.05) and adequate bowel preparation rate (94.9% vs. 96.3%, P >0.05) were similar between the 2 groups. The mean VAS score for taste (7.62 vs. 6.87, P =0.006) was significantly higher in the SPMC group than in the OSS group. There were no significant differences in any other safety variables between the 2 groups except nausea symptom (36.1% vs. 20.3%, P =0.008). Conclusions Bowel preparation for colonoscopy using low volume OSS and SPMC yielded similar ADRs and levels of efficacy. SPMC had higher levels of satisfaction for taste and feeling than did OSS.

Quality indicators in colonoscopy: the chasm between ideal and reality

“… 9 All patients should be educated on the split-dosing regimen for bowel preparation. Recently, low-volume preparation agents have been commonly used 42 , 43 ; therefore, sufficient education on low-fiber diets is becoming more important than before, when high-volume preparation agents were commonly used. European guidelines recommend a low-fiber diet on the day before colonoscopy but do not have any recommendations about the use of a low-fiber diet for >24 hours before the procedure.…”

No inferioridad entre dos agentes de bajo volumen (Picosulfato de Sodio/Citrato de Magnesio vs. Sulfato de Sodio/Potasio/Magnesio) en la preparación de colon para procedimientos diagnósticos: estudio observacional

“…Sin embargo, el grupo de SPMC superó significativamente al grupo OSS (p = 0,006). Las quejas más comunes fueron distensión y dolor abdominal (16,7 % frente a 10,2 % para los grupos OSS frente a SPMC) (40). En este estudio también existió una diferencia significativa (p < 0,001) en cuanto a la tolerabilidad de los pacientes frente a las diferentes preparaciones.…”

Comparison of the efficacy and safety between oral sulfate tablet and polyethylene glycol for bowel preparation before colonoscopy according to age

“…[ 1 ] High-quality bowel preparation is essential for complete examination of the colon mucosa during colonoscopy. [ 2 , 3 ] However, bowel preparation is inadequate for up to one-third of colonoscopic examinations. [ 4 , 5 ] Inadequate bowel preparation can decrease the adenoma detection rates and increase both the risk of complications following the colonoscopy as well as the procedure time.…”