Clinical comparison of primary versus secondary epilepsy in 125 cats

Pákozdy, Ákos; Leschnik, Michael; Sarchahi, Ali Asghar; Tichy, Alexander; Thalhammer, Johann G.

doi:10.1016/j.jfms.2010.07.001

Cited by 62 publications

(146 citation statements)

References 30 publications

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“…This prevalence is low compared with other previous published studies (Barnes and others 2004, Schriefl and others 2008, Pákoszy and others 2010, Wahle and others 2014) in which structural epilepsy was observed in 41–62 per cent of cats.…”

Section: Discussioncontrasting

confidence: 73%

Magnetic resonance imaging findings in epileptic cats with a normal interictal neurological examination: 188 cases

Raimondi¹,

Shihab²,

Gutierrez‐Quintana

et al. 2017

Veterinary Record

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Epilepsy is a common neurological condition in dogs and cats. Although an increased likelihood of significant brain lesions with age has been identified in neurologically normal dogs with epileptic seizures, the underlying aetiology of epileptic seizures in cats that present with normal physical and neurological examinations remains unknown. In this cross‐sectional study, the authors examined MRI findings in a large population of cats with a normal interictal physical and neurological examination. They hypothesised that age would have an impact on the prevalence of detectable lesions. First, following the guidelines for dogs and in accordance with previous studies, the authors divided the cats into three age groups (aged one year or younger, between one and six, and older than six) and calculated the proportion of cats with a detectable lesion on MRI in these groups. In the first group, 3/32 cats (9.4 per cent) had significant MRI abnormalities that were all consistent with congenital malformation; in the second group, only 5/92 (5.4 per cent) MRI scans were abnormal and in the third group, 15/ 65 (23.1 per cent) cats showed abnormal findings that were predominantly lesions of neoplastic origin. Second, to investigate the impact of age further, data were investigated as a continuous variable using receiver operating characteristic analysis. This indicated an optimal cut‐off age of five years, above which MRI abnormalities were more likely, with an increase in the odds of a significant structural lesion increasing by 14 per cent per year.

show abstract

Section: Discussioncontrasting

confidence: 73%

Magnetic resonance imaging findings in epileptic cats with a normal interictal neurological examination: 188 cases

Raimondi¹,

Shihab²,

Gutierrez‐Quintana

et al. 2017

Veterinary Record

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show abstract

“…7,10,11 Furthermore, the new ILAE classification system would allow veterinarians to use the term unknown epilepsy to label seizure disorders of cats that did not fit the previous traditional definition of idiopathic epilepsy. 7,10,11 Furthermore, the new ILAE classification system would allow veterinarians to use the term unknown epilepsy to label seizure disorders of cats that did not fit the previous traditional definition of idiopathic epilepsy.…”

mentioning

confidence: 99%

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Finnerty¹,

Heller²,

Mercier³

et al. 2014

javma

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Seizure control was achieved in most cats with a serum PB concentration between 15 and 45 μg/mL, regardless of the cause of the seizures. A modified 2011 ILAE classification was applied to cats with seizures and enabled classification of cats without specific genetic testing and without identified structural or inflammatory disease. This classification system should be incorporated into veterinary neurology nomenclature to standardize communication between veterinarians and improve comparisons among species.

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“…1 Causes of seizures and treatment options for cats are historically poorly described in the veterinary literature; however, there is a wealth of recently published clinical research focusing on feline seizures. 2,3,4,5,6,7 Underlying causes of seizures in cats are similar to those identified in dogs, although incidence varies between the two species, as do clinical manifestations of seizure activity. The goals of this article are to review recent veterinary literature related to feline seizures, with a focus on seizure classification, clinical manifestations, diagnostics, and treatment options.…”

Section: Introductionmentioning

confidence: 77%

“…Commonly reported causes of structural epilepsy in cats include infectious etiologies such as feline infectious peritonitis (FIP) or toxoplasmosis, noninfectious inflammatory disease (with neoplasms with meningioma and lymphoma being the most common), and ischemic or hemorrhagic infarcts. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] "Reactive seizures" are seizures occurring secondary to a systemic, toxic, or metabolic abnormality in the absence of an identifiable intracranial disease process. Because these seizures do not result from an intracranial cause, they are not classified as epilepsy even if they occur repeatedly.…”

Section: Classification and Seizure Etiologymentioning

confidence: 99%

Seizures and epilepsy in cats

Moore¹

2014

VMRR

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Seizures are a common presenting complaint in cats, although causes and options for the treatment of seizures in this species have been historically poorly described in the veterinary literature. Seizure manifestation in cats may be different than what is typically seen in dogs, but the underlying causes of seizure activity are the same. These include primary epilepsies, structural epilepsies, and reactive seizures. Although primary epilepsy was once believed to be rare in cats, we now commonly appreciate this syndrome, albeit at a lower frequency than in dogs. Because of this, a complete diagnostic work-up is recommended for all cats presenting for initial evaluation of seizures. Symptomatic treatment of seizures in cats is similar to dogs, with only a few limitations related to species-specific antiepileptic drug toxicities. The goal of this review is to summarize the recent veterinary literature related to feline seizures, with a focus on seizure classification, clinical manifestation, diagnostic evaluation, and treatment options.

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Clinical comparison of primary versus secondary epilepsy in 125 cats

Cited by 62 publications

References 30 publications

Magnetic resonance imaging findings in epileptic cats with a normal interictal neurological examination: 188 cases

Magnetic resonance imaging findings in epileptic cats with a normal interictal neurological examination: 188 cases

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Seizures and epilepsy in cats

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