A computer-administered form of the Hamilton Depression Rating Scale was designed to provide scores with a high degree of correspondence with the clinician-administered 17-item version of the scale. Both forms of the Hamilton scale were administered in a counterbalanced design to 97 subjects, including 52 outpatients with a Research Diagnostic Criteria diagnosis of Major Depression, 20 outpatients with Minor Depression, and 25 nonpsychiatric control subjects. Both the computerand clinician-administered interviews demonstrated high internal consistency reliability of .91 and .90, respectively. A correlation of .96 was found between the two versions, and the mean score difference between the two forms was nonsignificant for the total sample. Both forms also demonstrated clinical sensitivity and specificity in differentiating between Major and Minor Depression and Control group subjects. Overall results support the clinical and research use of the computer administered version of the Hamilton scale.Depression is one of the most common psychiatric diagnoses found in adults in this country (Hirschfeld & Cross, 1982), and is considered the number one mental health problem in the United States (Greist & Jefferson, 1984). A recent National Institute of Mental Health multisite Epidemiological Catchment Area study found a lifetime prevalence rate of affective disorders, as denned by the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; DSM-IH-R; American Psychiatric Association, 1987) of 8.3%, with a one-month prevalence rate of 2.2% for a major depressive episode and 3.3% for dysthymia (Regier et al., 1988).For the evaluation of depression, the clinical interview is generally considered the most accurate assessment methodology (Hamilton, 1982). One of the first semi-structured interview measures for the clinical evaluation of severity of depressive symptomatology is the Hamilton Depression Rating Scale (HDRS;Hamilton, 1960;1967). The Hamilton scale has become a standard for the measurement of clinical levels (as opposed to diagnosis) of depression (