Clinical considerations in face transplantation

Pushpakumar, Sathnur; Barker, John H.; Soni, Chirag; Joseph, Hazel; Aalst, Vera C. van; Banis, Joseph C.; Frank, Johannes

doi:10.1016/j.burns.2010.01.011

Cited by 29 publications

(23 citation statements)

References 25 publications

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“…All of these may require multiple staged surgeries and even then in the best of cases may not achieve satisfactory appearance and function [2]. Autologous grafts are often considered the clinical gold standard, because allografts, xenografts, and synthetic materials are associated with complications such as pathogen transmission, immune rejection, and suboptimal integration [38][39][40][41][42][43].…”

Section: Tissue Substitutes For Facial Reconstructionmentioning

confidence: 99%

“…The patient will invariably experience additional trauma, pain, scarring, disfigurement or other donor site complications [50][51][52]. In addition, it has been noted that though autologous grafts and flaps do a good job of replacing skeletal and soft tissue defects, they may not adequately restore the delicate complex facial anatomy [2]. Also, in respect of the skin, there is often a mismatch between the transferred and adjacent original tissues giving a patchwork appearance thereby falling short of the ultimate goal of facial reconstruction [2].…”

Section: Tissue Substitutes For Facial Reconstructionmentioning

confidence: 99%

“…In addition, it has been noted that though autologous grafts and flaps do a good job of replacing skeletal and soft tissue defects, they may not adequately restore the delicate complex facial anatomy [2]. Also, in respect of the skin, there is often a mismatch between the transferred and adjacent original tissues giving a patchwork appearance thereby falling short of the ultimate goal of facial reconstruction [2]. In the light of this consideration, facial allotransplantation has been adopted.…”

Section: Tissue Substitutes For Facial Reconstructionmentioning

confidence: 99%

“…Although, facial allotransplantation is built on the fundamental techniques of microvascular and microneural surgery, like any form of allograft, it is confronted by a lot of immunologic, ethical, psychological and socio-cultural considerations [2]. Hence, a clear guidelines of indications and contraindications must be followed and a case-by-case consideration of patients undertaken before embarking on facial allotransplantation [59,60].…”

Section: Facial Allotransplantationmentioning

confidence: 99%

“…It ranges from distortion of self-image and low selfesteem to withdrawal from social interaction which may lead to chronic stress and depression with suicidal tendencies [1,2]. Therefore, the task of correcting facial disfigurement is a challenging one to the reconstructive surgeons [3].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evolution and Trends in Reconstructive Facial Surgery: An Update

Akadiri

2012

J. Maxillofac. Oral Surg.

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Surgical correction of congenital and acquired facial deformities has transcended the primitive era of using non biologic materials to current attempts at own face growing through biotechnology. A summative account of this trend is still lacking in the literature. The objective of this article is to present an update on current knowledge in the strides to achieve functionally and aesthetically perfect facial reconstruction. It highlights the impact of advancements in 3D imaging, stereolithographic biomodelling, microvascular surgical tissue transplantation and tissue biotechnology in the surgical efforts to solve the problems of facial disfigurement whether congenital or acquired.

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