Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer

Oguma, Tsuyoshi; Nagaoka, Takashi; Kurahashi, M.; Kobayashi, Naofumi; Yamamori, Shinji; Tsuji, Chizuko; Takiguchi, Hiroto; Niimi, Kyoko; Tomomatsu, Hiromi; Tomomatsu, Katsuyoshi; Hayama, Naoki; Aoki, Takuya; Urano, Tetsuya; Magatani, Kazushige; Takeda, Sunao; Abe, Tadashi; Asano, Koichiro

doi:10.1371/journal.pone.0174802

Cited by 38 publications

(34 citation statements)

References 18 publications

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“…A total of 139 studies were included in the present review. From the total of 60 cross-sectional clinical studies selected [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ], 33 ...…”

Section: Statistics Of Included Studiesmentioning

confidence: 99%

“…From the total number of participants, 421 were children with 229 children having asthma and 192 children acting as the controls. Of the selected clinical studies, thirty-two of them reported that they used mixed expired breath [ 13 , 17 , 19 , 21 , 33 , 34 , 36 , 38 , 41 , 42 , 43 , 45 , 46 , 54 , 59 , 60 , 61 , 62 , 64 , 66 , 67 , 68 , 69 , 71 , 72 , 73 , 75 , 76 , 78 , 80 , 83 , 85 ] (consisting normally in a mixture of gaseous breath, that also includes the volatile components) collected by simple expiration in bags, tubes with absorbent materials or directly into the used instrumentation (as in the case of E-noses, for example). A total of twenty-two of them reported the use of alveolar breath [ 14 , 15 , 16 , 18 , 22 , 32 , 35 , 37 , 44 , 48 , 56 , 57 , 58 , 65 , 70 , 74 , 77 , 79 , 81 , 82 , 84 , …”

Section: Statistics Of Included Studiesmentioning

confidence: 99%

“…In the research related to the diagnosis of lung cancer, GC-MS has been widely used, accounting for more than 50% of studies. In the 15 studies included in this present review, GC-MS was used for analyses [ 13 , 16 , 22 , 44 , 48 , 60 , 62 , 69 , 70 , 72 , 75 , 80 , 82 , 84 , 86 ], while in another three studies, GC-MS was used as an additional confirmatory method [ 21 , 58 , 78 ].…”

Section: Diagnosis Of Investigated Respiratory Diseasesmentioning

confidence: 99%

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Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Rațiu

Ligor

Bocoş-Binţinţan

et al. 2020

JCM

116

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Lung cancer, chronic obstructive pulmonary disease (COPD) and asthma are inflammatory diseases that have risen worldwide, posing a major public health issue, encompassing not only physical and psychological morbidity and mortality, but also incurring significant societal costs. The leading cause of death worldwide by cancer is that of the lung, which, in large part, is a result of the disease often not being detected until a late stage. Although COPD and asthma are conditions with considerably lower mortality, they are extremely distressful to people and involve high healthcare overheads. Moreover, for these diseases, diagnostic methods are not only costly but are also invasive, thereby adding to people’s stress. It has been appreciated for many decades that the analysis of trace volatile organic compounds (VOCs) in exhaled breath could potentially provide cheaper, rapid, and non-invasive screening procedures to diagnose and monitor the above diseases of the lung. However, after decades of research associated with breath biomarker discovery, no breath VOC tests are clinically available. Reasons for this include the little consensus as to which breath volatiles (or pattern of volatiles) can be used to discriminate people with lung diseases, and our limited understanding of the biological origin of the identified VOCs. Lung disease diagnosis using breath VOCs is challenging. Nevertheless, the numerous studies of breath volatiles and lung disease provide guidance as to what volatiles need further investigation for use in differential diagnosis, highlight the urgent need for non-invasive clinical breath tests, illustrate the way forward for future studies, and provide significant guidance to achieve the goal of developing non-invasive diagnostic tests for lung disease. This review provides an overview of these issues from evaluating key studies that have been undertaken in the years 2010–2019, in order to present objective and comprehensive updated information that presents the progress that has been made in this field. The potential of this approach is highlighted, while strengths, weaknesses, opportunities, and threats are discussed. This review will be of interest to chemists, biologists, medical doctors and researchers involved in the development of analytical instruments for breath diagnosis.

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Section: Statistics Of Included Studiesmentioning

confidence: 99%

Section: Statistics Of Included Studiesmentioning

confidence: 99%

Section: Diagnosis Of Investigated Respiratory Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Rațiu

Ligor

Bocoş-Binţinţan

et al. 2020

JCM

116

View full text Add to dashboard Cite

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“…However, cyclohexane has been mentioned in two studies in association with pulmonary diseases. First, Oguma et al described increased levels of cyclohexane (and xylene) in patients with lung cancer compared to healthy controls (after ruling out possible confounders such as age, smoking status, gender and pulmonary function) [ 23 ]. Furthermore, the authors described an increase in cyclohexane (and xylene) levels in breath samples with progressing disease and a decrease in the healing process [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

et al. 2021

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The aim of this study was to analyze the exhaled volatile organic compounds (VOCs) profile, airway microbiome, lung function and exercise performance in congenital diaphragmatic hernia (CDH) patients compared to healthy age and sex-matched controls. A total of nine patients (median age 9 years, range 6–13 years) treated for CDH were included. Exhaled VOCs were measured by GC–MS. Airway microbiome was determined from deep induced sputum by 16S rRNA gene sequencing. Patients underwent conventional spirometry and exhausting bicycle spiroergometry. The exhaled VOC profile showed significantly higher levels of cyclohexane and significantly lower levels of acetone and 2-methylbutane in CDH patients. Microbiome analysis revealed no significant differences for alpha-diversity, beta-diversity and LefSe analysis. CDH patients had significantly lower relative abundances of Pasteurellales and Pasteurellaceae. CDH patients exhibited a significantly reduced Tiffeneau Index. Spiroergometry showed no significant differences. This is the first study to report the VOCs profile and airway microbiome in patients with CDH. Elevations of cyclohexane observed in the CDH group have also been reported in cases of lung cancer and pneumonia. CDH patients had no signs of impaired physical performance capacity, fueling controversial reports in the literature.

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“…Gennaro et al [69] related this finding with the hypothesis of a relationship between reactions of xenobiotic agents' degradation and the neoplastic processes [76,77] as cyclohexane is a metabolite of ε-caprolactam. Cyclohexane has also been proposed to be indicative of oxidative stress in the exhaled breath of lung cancer and colorectal cancer patients [78,79]. However, the exact mechanism underlying its endogenous origin is still not clear.…”

Section: Discussionmentioning

confidence: 99%

Exhaled Breath Analysis in Diagnosis of Malignant Pleural Mesothelioma: Systematic Review

Töreyin

Ghosh

Göksel

et al. 2020

IJERPH

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Malignant pleural mesothelioma (MPM) is mainly related to previous asbestos exposure. There is still dearth of information on non-invasive biomarkers to detect MPM at early stages. Human studies on exhaled breath biomarkers of cancer and asbestos-related diseases show encouraging results. The aim of this systematic review was to provide an overview on the current knowledge about exhaled breath analysis in MPM diagnosis. A systematic review was conducted on MEDLINE (PubMed), EMBASE and Web of Science databases to identify relevant studies. Quality assessment was done by the Newcastle–Ottawa Scale. Six studies were identified, all of which showed fair quality and explored volatile organic compounds (VOC) based breath profile using Gas Chromatography Coupled to Mass Spectrometry (GC–MS), Ion Mobility Spectrometry Coupled to Multi-capillary Columns (IMS–MCC) or pattern-recognition technologies. Sample sizes varied between 39 and 330. Some compounds (i.e, cyclohexane, P3, P5, P50, P71, diethyl ether, limonene, nonanal, VOC IK 1287) that can be indicative of MPM development in asbestos exposed population were identified with high diagnostic accuracy rates. E-nose studies reported breathprints being able to distinguish MPM from asbestos exposed individuals with high sensitivity and a negative predictive value. Small sample sizes and methodological diversities among studies limit the translation of results into clinical practice. More prospective studies with standardized methodologies should be conducted on larger populations.

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Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer

Cited by 38 publications

References 18 publications

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

Exhaled Breath Analysis in Diagnosis of Malignant Pleural Mesothelioma: Systematic Review

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