Clinical Control of Packed RBC Transfusion in Acute Surgical Pathology such as Gastric Dilation and Volvulus in Dogs

Vatnikov, Yury Anatolyevich; Sakhno, N. V.; Sotnikova, E.D.; Kulikov, Evgeny Vladimirovich; Паршина, Валентина; Troshina, Natalya

doi:10.13005/bpj/817

Cited by 5 publications

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“…The present study contributes to the differential diagnosis of liver lesions and metastatogenesis in dogs as well as to the differentiation of liver cancers from other diseases, including hereditary etiology [11,30,31].…”

Section: Introductionmentioning

confidence: 99%

Influence of hepatic neoplasia on life expectancy in dogs

et al. 2020

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Background and Aim: The present study investigated the influence of liver tumor structure on life expectancy in dogs. Diseases of the liver comprise 5-25% of all non-communicable diseases in dogs, and primary hepatic tumors account for 0.6-1.3% of tumors. This research aimed to study the post-operative life span of animals with primary or metastatic tumors of the liver. Materials and Methods: During the study period, 7124 oncological operations were performed in our clinic. In total, 128 liver tumors were detected in live animals, while 323 were detected posthumously. Forty animals underwent surgery for various liver tumors. In dogs with primary liver tumors, the average age was 11.9 years and the average body weight was 15.5 kg, while in dogs with liver metastases, the mean age was 11.4 years and the average body weight was 24 kg. Results: The ratio of males to females among dogs with primary liver tumors was about 1:1 (ten females and nine males), while that among dogs with metastatic liver damage was clearly predominantly female (14 females and two males) because females often undergo surgery for cancerous mammary glands or ovaries. Conclusion: The size of tumors and the number of affected lobes had a significant effect on the post-operative life span. With a tumor size of <5 cm and a lesion covering less than two lobes of the liver, life expectancy was significantly longer and the prognosis was more favorable. In cases of large tumors or those affecting more than two lobes, life expectancy was significantly reduced and the prognosis was cautious to unfavorable.

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Section: Introductionmentioning

confidence: 99%

Influence of hepatic neoplasia on life expectancy in dogs

et al. 2020

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“…Therefore, in contrast to other pathologies that do not directly target spleen, [18] splenectomy will not have the intended effect. There are two forms of splenic amyloidosis -sago and lardaceous.…”

Section: Resultsmentioning

confidence: 99%

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Sotnikova

2017

AJP

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Introduction: Familial Shar-Pei amyloidosis is an autoinflammatory systemic disease characterized by pathological synthesis of the fibrillary protein in the cells of the reticuloendothelial system, followed by amyloid formation. The purpose of our research is mainly focused on the investigation of specific structural histological changes in kidneys, liver, and spleen of the Shar-Pei dogs suffering from familial amyloidosis. Materials and Methods: The studies included autopsy and post-mortem examination of the Shar-Pei dogs with the presumptive diagnosis of familial amyloidosis or other diagnoses. Samples of kidney, liver, and spleen tissues of all cadavers were collected for histological examination. Results: Our studies showed that amyloid was formed within the ground substance of the connective tissue. Early amyloid deposits were observed in the spleen samples, providing the pathomorphological marker of the initial stage of the process generalization, whereas during the later stages, amyloid was found in kidneys, liver, and myocardium. Gradually increasing amyloid deposits lead to compression and atrophy of the parenchymal cells, sclerosis, and multiple organ dysfunction syndrome, manifesting as a wide range of clinical signs. Discussion: As a result of the conducted post-mortem examination, we have revealed systemic amyloidosis in the cadavers of the animals, initially admitted with various pathologies, which proves the importance and relevance of timely diagnostics, detection of clinical manifestations, and latent forms of the condition. Histological examination is one of the most accurate diagnostic methods for this pathology.

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“…Systemic inflammation response syndrome (SIRS) in animals was recorded on the basis of anamnesis, clinical examination, and the results of a complete blood count. Diagnosis of surgical sepsis was based on the presence of the source of infection and SIRS [9-11]. The number of diseased animals was 30 dogs of both sexes and medium-breeds (n=30, Group 2).…”

Section: Methodsmentioning

confidence: 99%

Special aspects of systemic inflammation course in animals

Chernigova

Chernigov²,

Vatnikov

et al. 2019

Vet World

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Aim: In this study, we identified characteristics of systemic inflammation associated with surgical sepsis in animals. We evaluated the role of purine metabolism, functionally associated lipoperoxidation processes of membrane structures, and the antioxidant system in the development of surgical sepsis in dogs. Materials and Methods: Dogs with a provisional exclusion of sepsis were included in the study. The control group (Group 1) included clinically healthy dogs (n=5), and medium-breed dogs with systemic inflammation response syndrome (n=30) were categorized in the experimental group (Group 2). Along with hemogram and biochemical analysis, we determined the amount of malondialdehyde, glutathione, superoxide dismutase, catalase, glutathione reductase, and glucose-6-phosphate dehydrogenase on the 1st and 14th day of the study. Treatment included a thorough reorganization of the septic focus, followed by antibacterial therapy. Sick animals were injected with a drug (dexamethasone) that suppresses the synthesis and inhibits the action of inflammatory mediators. Decompensation of the functions of organs and systems was carried out using symptomatic therapy. Results: We found that enhanced lipid peroxidation of unsaturated fatty acids of membrane structures stimulates the generalization of inflammatory process, as evidenced by the significant deviation from the physiologically normal values of lipid peroxidation, C-reactive protein, blood cell count, etc. The course of systemic inflammation associated with surgical sepsis in animals can be attributed to several consistently developing processes that function as a result of increased purine mononucleotide catabolism, peroxide compound formation, and their excessive breakdown in reactions associated with the consumption of glutathione due to the insufficient recovery of glutathione disulfide. Conclusion: The amount of uric acid, glycosaminoglycans, hyaluronic acid in blood plasma, and the content of malondialdehyde, glutathione, and glutathione reductase in erythrocytes should be considered when assessing the severity of the systemic inflammatory process. The increased glutathione requirement in dogs with surgical sepsis requires intervention with pharmacological agents, and further research is needed in this aspect.

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Clinical Control of Packed RBC Transfusion in Acute Surgical Pathology such as Gastric Dilation and Volvulus in Dogs

Cited by 5 publications

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Influence of hepatic neoplasia on life expectancy in dogs

Influence of hepatic neoplasia on life expectancy in dogs

Untitled

Special aspects of systemic inflammation course in animals

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