Clinical correlates of autoimmune thyroiditis and non-autoimmune hypothyroidism in treatment-naïve patients with major depressive disorders

Wu, Siqi; Wang, Haitao; Zhou, Yue; Xia, Xingzhi; Yue, Yan; Wu, Yuxuan; Peng, Ruijie; Yang, Ruchang; Li, Ronghua; Yuan, Nian; Li, Zhe; Zhao, Xuechao; Yin, Ming; Du, Xiangdong; Zhang, Xiangyang

doi:10.1016/j.jad.2022.12.037

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…A retrospective case study of 93 inpatients in a mood disorders unit found that patients with treatment-resistant depression were significantly more likely to have subclinical or overt hypothyroidism than those with non-treatment-resistant depression (22% vs. 2%, p < 0.01) [ 97 ]. Wu et al [ 98 ] studied outcomes in non-autoimmune hypothyroidism and AITD groups among 1718 outpatients with treatment-naïve major depressive disorder (MDD). Although both groups were associated with the duration of MDD, Hamilton Depression Scale score, severity of anxiety, and MS, only the AITD group with subclinical hypothyroidism was associated with suicide attempts [ 98 ].…”

Section: Other Associations Of the Interaction Of Aitd And Ra: Female...mentioning

confidence: 99%

“…Wu et al [ 98 ] studied outcomes in non-autoimmune hypothyroidism and AITD groups among 1718 outpatients with treatment-naïve major depressive disorder (MDD). Although both groups were associated with the duration of MDD, Hamilton Depression Scale score, severity of anxiety, and MS, only the AITD group with subclinical hypothyroidism was associated with suicide attempts [ 98 ].…”

Section: Other Associations Of the Interaction Of Aitd And Ra: Female...mentioning

confidence: 99%

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Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Lichtiger,

Fadaei,

Tagoe

2024

Clin Rheumatol

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Autoimmune thyroid disease (AITD) is the most prevalent autoimmune disease. It shares multiple genetic, clinical, and serologic characteristics with rheumatoid arthritis (RA). Although frequently described as a classic form of single-organ autoimmunity, the AITD disease burden in a subset of patients extends well beyond the thyroid gland. This review explores the complex interaction between the two diseases and the clinical consequences when they overlap. Beyond the well-known effects of AITD on thyroid function in RA, there is mounting evidence of the association of both conditions impacting the presentation and outcomes of diabetes, metabolic syndrome, and cardiovascular disease. An increasing number of studies suggest that there are negative effects of AITD on RA disease activity both in the presence and in the absence of thyroid dysfunction. Recent evidence suggests that AITD may not only worsen the cumulative damage of RA through higher disease activity but may also worsen secondary osteoarthritis changes. Less well-known is the significant association between AITD and chronic widespread pain syndromes including fibromyalgia. Importantly, the presence of fibromyalgia, which is increased in RA patients, appears to be further increased when it overlaps with AITD. Lastly, we probe the possible influence of AITD interacting with RA on fertility and clinical depression. Key Points• Autoimmune thyroid disease is the most common autoimmune disease and is frequently associated with rheumatoid arthritis.• Autoimmune thyroid disease can present with osteoarthritis, inflammatory arthritis, and chronic widespread pain syndromes.• The co-occurrence of autoimmune thyroid disease and rheumatoid arthritis may worsen disease activity and exacerbate other disease manifestations including cardiovascular disease, fertility, and depression.• The overlap of rheumatoid arthritis with autoimmune thyroid disease needs further research and should be sought in general clinical practice.

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Section: Other Associations Of the Interaction Of Aitd And Ra: Female...mentioning

confidence: 99%

Section: Other Associations Of the Interaction Of Aitd And Ra: Female...mentioning

confidence: 99%

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Lichtiger,

Fadaei,

Tagoe

2024

Clin Rheumatol

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Section: Autoimmunity and Psychiatric Disordersmentioning

confidence: 99%

“…Given the association of MDD with autoimmune disorders, the suboptimal mitochondrial function and the dysregulated tryptophan-melatonin pathway, it has been proposed that some MDD presentations may be conceptualized as 'autoimmune' disorders, as with MDD presentations arising from subclinical hypothyroidism driven by thyroid autoimmunity [197]. These authors showed autoimmune thyroiditis to be significantly positively correlated with MDD and anxiety scores as well as metabolic syndrome and suicide attempts [197]. Interestingly, the thyroid-stimulating hormone induces the melatonergic pathway enzymes in thyroid C-cells, which release melatonin to regulate the thyroid gland function, including by the direct regulation of thyroglobulin gene expression in follicular cells [198].…”

Section: Autoimmunity and Psychiatric Disordersmentioning

confidence: 99%

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Anderson¹,

Almulla

Reíter

et al. 2023

Cells

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Although previously restricted to a limited number of medical conditions, there is a growing appreciation that ‘autoimmune’ (or immune-mediated) processes are important aspects of a wide array of diverse medical conditions, including cancers, neurodegenerative diseases and psychiatric disorders. All of these classes of medical conditions are associated with alterations in mitochondrial function across an array of diverse cell types. Accumulating data indicate the presence of the mitochondrial melatonergic pathway in possibly all body cells, with important consequences for pathways crucial in driving CD8+ T cell and B-cell ‘autoimmune’-linked processes. Melatonin suppression coupled with the upregulation of oxidative stress suppress PTEN-induced kinase 1 (PINK1)/parkin-driven mitophagy, raising the levels of the major histocompatibility complex (MHC)-1, which underpins the chemoattraction of CD8+ T cells and the activation of antibody-producing B-cells. Many factors and processes closely associated with autoimmunity, including gut microbiome/permeability, circadian rhythms, aging, the aryl hydrocarbon receptor, brain-derived neurotrophic factor (BDNF) and its receptor tyrosine receptor kinase B (TrkB) all interact with the mitochondrial melatonergic pathway. A number of future research directions and novel treatment implications are indicated for this wide collection of poorly conceptualized and treated medical presentations. It is proposed that the etiology of many ‘autoimmune’/‘immune-mediated’ disorders should be conceptualized as significantly determined by mitochondrial dysregulation, with alterations in the mitochondrial melatonergic pathway being an important aspect of these pathoetiologies.

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“…A systematic review on the topic highlighted that individuals with an anxiety disorder seem to be significantly more likely to have a co-occurring thyroid disorder ( Fischer and Ehlert, 2018 ). Intriguingly, a recent study explored the relationship between SH and anxiety symptom in young first-episode and drug-naïve patients with major depressive disorder ( Wu et al, 2023 ). The authors reported that high serum TSH level was associated with anxious major depressive disorder in young first-episode and drug-naïve individuals with major depressive disorder and SH, thus suggesting serum TSH level could be a possible biomarker for predicting anxiety symptoms, at least for the population considered in the study.…”

Section: Introductionmentioning

confidence: 99%

Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome

Fucà,

Costanzo,

Galassi

et al. 2024

Front. Psychol.

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BackgroundSubclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features associated with SH in children with DS.ObjectiveThe first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.MethodsWe included in this retrospective study 98 participants with DS aged 3–18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.ResultsParticipants with co-occurring SH exhibited significantly higher scores at several scales of the Conners’ Parent Rating Scales Long Version – Revised. However, they did not exhibit more sleep problems than control group.ConclusionThese results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS.

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Clinical correlates of autoimmune thyroiditis and non-autoimmune hypothyroidism in treatment-naïve patients with major depressive disorders

Cited by 7 publications

References 46 publications

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome

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