Clinical correlates of depression chronicity among people living with HIV: What is the role of suicidal ideation?

Tyree, Griffin A.; Vaida, Florin; Zisook, Sidney; Mathews, W. Christopher; Grelotti, David J.

doi:10.1016/j.jad.2019.07.081

Cited by 9 publications

(9 citation statements)

References 48 publications

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“…107 articles used measurement tools to identify the condition of suicidal behavior and risk factors. There were 66 articles on suicidal ideation, 38 on suicidal attempts, 47 on completed suicide, 39 on suicidal ideation and attempts, 1 on suicidal ideation and death by suicide [ 95 ], and three on suicidal ideation, suicide attempts, and completed suicides [ 78 , 79 , 91 ]. Most of the studies evaluated risk factors; however, 23 did not mention risk factors ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Tsai

Mudiyanselage

et al. 2023

PLoS ONE

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Death by suicide is a major public health problem. People living with human immunodeficiency virus (PLHIV) have higher risk of suicidal behavior than the general population. The aim of this review is to summarize suicidal behavior, associated risk factors, and risk populations among PLHIV. Research studies in six databases from January 1, 1988, to July 8, 2021, were searched using keywords that included “HIV,” “suicide,” and “risk factors.” The study design, suicide measurement techniques, risk factors, and study findings were extracted. A total of 193 studies were included. We found that the Americas, Europe, and Asia have the highest rates of suicidal behavior. Suicide risk factors include demographic factors, mental illness, and physiological, psychological, and social support. Depression is the most common risk factor for PLHIV, with suicidal ideation and attempt risk. Drug overdosage is the main cause of suicide death. In conclusion, the current study found that PLHIV had experienced a high level of suicidal status. This review provides an overview of suicidal behavior and its risk factors in PLHIV with the goal of better managing these factors and thus preventing death due to suicide.

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Section: Resultsmentioning

confidence: 99%

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Tsai

Mudiyanselage

et al. 2023

PLoS ONE

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“…Risk factors for HIV transmission also remain stable, and include sharing of needles and syringes, having condomless intercourse, exchanging of sex for drugs, money, or other goods, and having other sexually transmitted infections [ 3 , 4 , 5 ]. These behavioral risk factors are additionally associated with a range of psychosocial sequelae, such as depression and suicidal ideation [ 6 , 7 , 8 ], psychological distress [ 9 , 10 ], alcohol and substance use and abuse disorders [ 11 , 12 , 13 ], disrupted social support [ 14 , 15 , 16 ], and experiences with violence [ 17 ]. Despite the extensive literature, which details HIV related risk behaviors and their synergistic impact on health outcomes, new perspectives that include a life-course perspective, are critical to ending the HIV epidemic.…”

Section: Introductionmentioning

confidence: 99%

Sexual Risk Behavior and Lifetime HIV Testing: The Role of Adverse Childhood Experiences

Dyer

Turpin

Hawthorne

et al. 2022

IJERPH

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Despite the success of HIV prevention drugs such as PrEP, HIV incident transmission rates remain a significant problem in the United States. A life-course perspective, including experiences of childhood adversity, may be useful in addressing the HIV epidemic. This paper used 2019 BRFSS data to elucidate the role that childhood adversity plays in the relationship between HIV risk and HIV testing. Participants (n = 58,258) completed self-report measures of HIV risk behaviors, HIV testing, and adverse childhood experiences (ACEs). The median number ACEs in the sample was 1, with verbal abuse (33.9%), and parental separation (31.3%) being the most common ACEs reported. Bivariate findings showed that all ACEs were associated with increased HIV risk and testing. However, increased risk was not correlated with increased HIV testing, with the highest incongruence related to mental health problems of household member (53.48%). While both self-reported HIV risk and ACEs were positively associated with HIV testing, their interaction had a negative association with testing (aPR = 0.51, 95%CI 0.42, 0.62). The results highlight the need for targeted HIV prevention strategies for at-risk individuals with a history of childhood adversity.

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“…Depression is a vital concern due to the clinical presentations of amotivation, sleep disturbances, apathy and suicidal ideation. 3 People living with HIV who exhibit amotivation and other depressive-related symptoms are more likely to be non-adherent and tend to have a poor outlook on life. 3 Some antiretrovirals (ARVs) are known to cause neuropsychiatric adverse effects such as depression.…”

Section: Introductionmentioning

confidence: 99%

“…3 People living with HIV who exhibit amotivation and other depressive-related symptoms are more likely to be non-adherent and tend to have a poor outlook on life. 3 Some antiretrovirals (ARVs) are known to cause neuropsychiatric adverse effects such as depression. 4 Identifying ARVs associated with neuropsychiatric adverse effects or neurotoxicities can assist in properly assessing potential risk factors that can lead to non-adherence and discontinuation due to intolerance; thereby ensuring practitioners provide the most comprehensive care in the management of HIV.…”

Section: Introductionmentioning

confidence: 99%

Neurotoxicities in the treatment of HIV between dolutegravir, rilpivirine and dolutegravir/rilpivirine: a meta-analysis

et al. 2021

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ObjectiveTo assess the risk of neuropsychiatric adverse effects (ie, depression, anxiety, insomnia, dizziness, suicidal behaviour) among patients treated with rilpivirine, dolutegravir and dolutegravir/rilpivirine.DesignThis is a systematic review and meta-analysis of randomised controlled trials. Quality of evidence was assessed using Jadad scoring system.Data sourcesThree electronic databases were searched for available publications up to 1 May 2020. Searches included relevant studies, trial registers, conference proceeding abstracts and grey literature.Inclusion criteriaRandomised controlled trials with data focused on adult participants (ie, 18 years of age or older) receiving dolutegravir 50 mg, rilpivirine 25 mg or combination of dolutegravir 50 mg/rilpivirine 25 mg once daily.ResultsTwenty studies with a minimum duration of 48 weeks and average Jadad score of 4 were included (n=10 998). Primary objective demonstrated a relative risk (RR) synergistic effect on depressive symptoms for dolutegravir/rilpivirine (RR=2.82; 95% CI (1.12 to 7.10)) when compared with dolutegravir (RR=1.10; 95% CI (0.88 to 1.38)) and rilpivirine (RR=1.08; 95% CI (0.80 to 1.48)). Secondary objectives showed no difference between dolutegravir, rilpivirine and dolutegravir/rilpivirine to efavirenz. Additionally, excluding efavirenz studies, dolutegravir and dolutegravir/rilpivirine yielded increased depression (RR=1.34; 95% CI (1.04 to 1.74)).ConclusionThe combination of dolutegravir/rilpivirine appears to increase the risk of depressive symptoms. Despite the increase, the clinical significance is unknown and needs further study. Additionally, neurotoxicity risk appears similar between dolutegravir, rilpivirine and dolutegravir/rilpivirine antiretroviral therapy when compared with efavirenz-based antiretroviral therapy.

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Clinical correlates of depression chronicity among people living with HIV: What is the role of suicidal ideation?

Cited by 9 publications

References 48 publications

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Sexual Risk Behavior and Lifetime HIV Testing: The Role of Adverse Childhood Experiences

Neurotoxicities in the treatment of HIV between dolutegravir, rilpivirine and dolutegravir/rilpivirine: a meta-analysis

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