Clinical correlates of social adjustment in patients with obsessive-compulsive disorder

Rosa, Ana Carolina Ferreira; Diniz, Juliana Belo; Fossaluza, Victor; Torres, Albina Rodrigues; Fontenelle, Leonardo F.; Mathis, Alice Simões De; Rosário, Maria da Conceição; Miguel, Eurí­pedes Constantino; Shavitt, Roseli Gedanke

doi:10.1016/j.jpsychires.2012.05.019

Cited by 52 publications

(25 citation statements)

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“…Typical anxiolytics also have no clinical value in treating OCD (Fineberg and Craig, 2007). Nevertheless, OCD is often comorbid with social anxiety disorder (Assuncão et al, 2012; Kim et al, 2012) or poor social adjustment (Rosa et al, 2012), while it is widely recognized that OCD-related obsessions are accompanied with severe anxiety that in turn is alleviated by the apparent “anxiolytic” effect brought about by compulsive and repetitive acts.…”

Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

“…Furthermore, comorbid OCD and social impairment demonstrate greater OC symptom severity and treatment resistance (Alarcon et al, 1993; Khanna et al, 1988), while greater OC severity with poor social functioning predict a poor treatment outcome (Stewart et al, 2010). Finally, greater OCD severity may worsen social impairment and vice versa (Rosa et al,2012). Considering children, young OCD sufferers tend to be more socially isolative in scenarios where normal peers may observe their behavior (Piacentini et al, 2003).…”

Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

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Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

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Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests.

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Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

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“…Scores on psychosocial functioning are also lower compared to most other psychiatric disorders, and similar to schizophrenia, which is considered one of the most severe psychiatric disorders in terms of social impairments (9). Moreover, higher symptom severity has been found to be associated with poorer social adjustment (10). The extent to which these self-reported social impairments of patients with OCD simply result as a consequence of the invalidating nature of the disorder, e.g., when a patient is not able to establish or maintain meaningful relations with others because their compulsions take up too much time, or whether factors more directly related to their symptomatology such as social-cognitive problems may play a role as well, is currently unknown.…”

Section: Introductionmentioning

confidence: 97%

Social Cognition and Obsessive-Compulsive Disorder: A Review of Subdomains of Social Functioning

2020

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Disturbances in social cognitive processes such as the ability to infer others' mental states importantly contribute to social and functional impairments in psychiatric disorders. Yet, despite established social, emotional, and cognitive problems, the role of social cognition in obsessive-compulsive disorder is largely overlooked. The current review provides a first comprehensive overview of social (neuro)cognitive disturbances in adult patients with obsessive-compulsive disorder. Results of our review indicate various social cognitive alterations. Patients with obsessive-compulsive disorder show deficits in the recognition of affective social cues, specifically facial expressions of disgust, and more general deficits in theory of mind/mentalizing. Additionally, patients show heightened affective reactions and altered neural responding to emotions of self and others, as well as poor emotion regulation skills, which may contribute to poor social functioning of patients. However, the discrepancies in findings and scarcity of studies make it difficult to draw firm conclusions with regard to the specificity of social cognitive disturbances. The review offers directions for future research and highlights the need to investigate obsessive-compulsive disorder from an interactive social neurocognitive perspective in addition to the prevalent passive spectator perspective to advance our understanding of this intricate and burdensome disorder.

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“…The clinical picture of people with obsessive-compulsive disorder (OCD) is characterized by recurrent obsessions and/or compulsions [1] and functional alterations that are observable in all areas of life [2]. Epidemiological data from several Canadian and American studies further support the association between social adjustment difficulties and obsessive-compulsive symptoms [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%