Clinical correlates of weight gain in first episode psychosis patients treated with olanzapine

Nutritional intervention to prevent weight gain in patients commenced on olanzapine: a randomized controlled trial

“…It is possible to reduce the percentage of people gaining clinically significant amounts of weight (more than 7% of their initial weight) following the commencement of olanzapine from 64% to 13%. A large body of published work shows a mean weight gain of between approximately 4 and 7.5 kg [4,7] following 3 months of olanzapine administration. In accordance with these findings, the controls in the present study had gained a mean of 6 kg approximately 4 months after the commencement of olanzapine (i.e.…”

“…Based on a meta‐analysis of 78 studies, the degree of weight gain appears to be an average of 4.15 kg during 10 weeks of olanzapine treatment [4]. More recently, a mean weight gain at 12 weeks of 7.3 kg has been reported [7]. The majority of weight gain occurs in the first 3 months following commencement of olanzapine [8], highlighting the importance of early intervention for weight gain mitigation.…”

Nutritional Intervention to Prevent Weight Gain in Patients Commenced on Olanzapine: A Randomizedcontrolled Trial

“…A large body of published work shows a mean weight gain of between approximately 4 and 7.5 kg [4,7] following 3 months of olanzapine administration. It is possible to reduce the percentage of people gaining clinically significant amounts of weight (more than 7% of their initial weight) following the commencement of olanzapine from 64% to 13%.…”

“…It is possible to reduce the percentage of people gaining clinically significant amounts of weight (more than 7% of their initial weight) following the commencement of olanzapine from 64% to 13%. A large body of published work shows a mean weight gain of between approximately 4 and 7.5 kg [4,7] following 3 months of olanzapine administration. In accordance with these findings, the controls in the present study had gained a mean of 6 kg approximately 4 months after the commencement of olanzapine (i.e.…”

“…Based on a meta-analysis of 78 studies, the degree of weight gain appears to be an average of 4.15 kg during 10 weeks of olanzapine treatment [4]. More recently, a mean weight gain at 12 weeks of 7.3 kg has been reported [7]. The majority of weight gain occurs in the first 3 months following commencement of olanzapine [8], highlighting the importance of early intervention for weight gain mitigation.…”