Clinical Correlation of Bone Marrow Microvessel Density in Essential Thrombocythemia

Panteli, K; Ζαγοριανάκου, Νεκταρία; Agnantis, Niki J.; Bourantas, Konstantinos L.; Bai, Maria

doi:10.1159/000086583

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…This indicates that angiogenesis is not involved, at least at diagnosis, in PV and ET. The scenario may change when patients with a long‐lasting PV or ET are considered, as suggested by Panteli et al (2005). Concerning different CMD, our study suggests that the evaluation of MVD may be an additional useful tool for pathologists to diagnose disease evolution and to discriminate between ET and PMF at the prefibrotic stage.…”

Section: Discussionmentioning

confidence: 71%

“…Its evaluation provides useful prognostic information in haematological malignancies, such as acute leukaemia, myelodysplastic syndromes (Aguayo et al , 2000; Keith et al , 2007) and multiple myeloma (Rajkumar et al , 2000; Pruneri et al , 2002). Of the CMDs, angiogenesis is the most evident in PMF (Mesa et al , 2000; Panteli et al , 2005). This study evaluated BM MVD in 115 patients with CMD and investigated its relationship with clinical, haematological and molecular features.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations

Boveri¹,

Passamonti

Rumi

et al. 2007

Br J Haematol

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SummaryPhiladelphia-negative chronic myeloproliferative disorders (CMD) include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Angiogenesis is critical in the pathogenesis of PMF. We studied angiogenesis in 115 patients with CMD (23 PV, 24 ET, 46 PMF, 12 post-PV and 10 post-ET myelofibrosis) by assessment of microvessel density (MVD) in bone marrow (BM). Kruskall-Wallis analysis of variance showed that patients with PMF had significantly higher values of MVD than those with PV (P < 0AE001), ET (P < 0AE001) and controls (P < 0AE001). MannWhitney U-test demonstrated that patients with PMF at the prefibrotic stage had significantly higher MVD values than those with ET (P = 0AE02). Patients with post-PV myelofibrosis showed significantly higher MVD values than those with PV (P < 0AE001), as did patients with post-ET myelofibrosis compared with ET (P < 0AE001). In patients with CMD, the multivariate generalized linear regression model showed that the JAK2 (V617F) mutational burden (P = 0AE01), serum lactate dehydrogenase level (P = 0AE003), and anaemia (P < 0AE001) independently correlated with MVD. In summary, this study indicates that assessment of BM angiogenesis, as measured by MVD, may be a useful additional tool in the histopathological definition of CMD.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations

Boveri¹,

Passamonti

Rumi

et al. 2007

Br J Haematol

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“…In contrast, cancer cell infiltration results in replacement of fatty marrow by cancer cells, increasing the cellular content of BM, with a focal, multifocal or diffuse distribution [43][44][45]. Angiogenesis, which facilitates malignancy perfusion, has been described in BM [46][47][48]. In certain specific malignancies, BM necrosis can occur, resulting in loss of myeloid tissue and marrow fat without trabecular destruction [43].…”

Section: Age-related Involutionmentioning

confidence: 99%

State-of-the-art of bone marrow analysis in forensic toxicology: a review

et al. 2010

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Although blood is the reference medium in the field of forensic toxicology, alternative matrices are required in case of limited, unavailable or unusable blood samples. The present review investigated the suitability of bone marrow (BM) as an alternative matrix to characterize xenobiotic consumption and its influence on the occurrence of death. Basic data on BM physiology are reported in order to highlight the specificities of this matrix and their analytical and toxicokinetic consequences. A review of case reports, animal and human studies involving BM sample analysis focuses on the various parameters of interpretation of toxicological results: analytic limits, sampling location, pharmacokinetics, blood/BM concentration correlation, stability and postmortem redistribution. Tables summarizing the analytical conditions and quantification of 45 compounds from BM samples provide a useful tool for toxicologists. A specific section devoted to ethanol shows that, despite successful quantification, interpretation is highly dependent on postmortem interval. In conclusion, BM is an interesting alternative matrix, and further experimental data and validated assays are required to confirm its great potential relevance in forensic toxicology.

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“…Only 10–20% of them harbor none of these three driver mutations ( 1 ) this group is referred to as having triple negative ET. Angiogenesis is increased in several types of cancer, including ET, where increased bone marrow angiogenesis is observed ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia

Vikman

Larsson

Thulin

et al. 2023

ujms

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Background: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated in treatment-naïve ET patients. Methods: Blood plasma from 41 ET patients and 43 healthy aged-matched controls was analyzed for eight different angiogenesis-related proteins. Results: The ET cohort displayed a more homogenous expression pattern of these proteins compared with controls. Five of the eight proteins were significantly increased in ET patients. Conclusion: Increased plasma levels of matrix metallopeptidase 9 (MMP9) and endostatin have not previously been reported in ET. In our patients, MMP9 levels correlated positively with Janus kinase 2 (JAK2) V617F allele burden and leukocyte count.

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Clinical Correlation of Bone Marrow Microvessel Density in Essential Thrombocythemia

Cited by 6 publications

References 45 publications

Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations

Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations

State-of-the-art of bone marrow analysis in forensic toxicology: a review

Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia

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