Clinical correlations of auditory P200 topography and left temporo-central deficits in schizophrenia: A preliminary study

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

“…These studies have shown that P200 abnormalities may be physiological markers for a positivesymptom subtype (Hegerl et al 1988;Schwarzkopf et al 1990) of schizophrenia. Thus, Roth et al (1981) demonstrated a negative correlation between the P200 latency to frequent tones and the delusion/hallucination score, and Laurent et al (1999) showed a negative correlation between P200 latency and the PANSS positive syndrome score, whereas a study by Shenton et al (1989) revealed that reduced P200 amplitudes correlated significantly with a negative-symptom subtype. Studies with ERPs in ADHD show enhanced amplitude or reduced latency or both of the P200 component compared to those of healthy controls.…”

Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials

“…Gating refers to a reduction in the second of two successive stimuli. Patients with schizophrenia also exhibit impaired auditory gating of the N100, P50 and P200 AEP components (Shenton, Faux et al 1989; Brockhaus-Dumke, Schultze-Lutter et al 2008). The latter two components are positive midlatency ERP constituents occurring 50 and 200 ms post-stimulus whose mouse analogs are the P20 and P80, respectively.…”

Electrophysiological Deficits in Schizophrenia: Models and Mechanisms

“…Numerous reports have demonstrated that amplitude and gating of the P200 are reduced in schizophrenia (Roth et al, 1981, Boutros et al, 2004a, Boutros et al, 2004b, Lijffijt et al, 2009a, Gjini et al, 2010. Moreover, reduced amplitude appears to be related to negative symptoms, in particular anhedonia and avolition (Shenton et al, 1989). P200 gating shows a positive relationship to attentional performance and the post-attentive cognitive P300 response (Boutros et al, 2004b, Lijffijt et al, 2009b.…”

“…P200 is reported to index early information processing, selective attention, and stimulus encoding (Shenton et al, 1989, Polich andSquire, 1993). Thus, the auditory temporal cortex has been highly implicated in P200 generation (Shenton et al, 1989). It is noteworthy that brain regions that are not primary sources of P200 may modify the response as a function of experimental conditions (e.g., attentive versus inattentive).…”