Clinical course and diagnosis of genital herpes simplex virus infection and evaluation of topical surfactant therapy

Vontver, Louis A.; Reeves, William C.; Rattray, Mark C.; Corey, Lawrence; Remington, Mike; Tolentino, Ernest; Schweid, Abraham I.; Holmes, King K.

doi:10.1016/0002-9378(79)90290-4

Cited by 53 publications

(11 citation statements)

References 11 publications

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“…Menstrual cycle results are consistent with those of 5 previous studies (compare Guinan et al 41 ), which found no increases in genital herpes recurrences 7,16,42,43 or in asymptomatic genital herpes viral shedding 44 during any phase of the menstrual cycle.…”

Section: Commentsupporting

confidence: 82%

Persistent Stress as a Predictor of Genital Herpes Recurrence

Cohen¹,

Kemeny²,

Kearney³

et al. 1999

Arch Intern Med

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Section: Commentsupporting

confidence: 82%

Persistent Stress as a Predictor of Genital Herpes Recurrence

Cohen¹,

Kemeny²,

Kearney³

et al. 1999

Arch Intern Med

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“…In some reports the association between ma-Sifakis/Koumantakis/Koffa/Ergazaki/ Spandidos ternal primary infection prior to 20 weeks and the possibility of a spontaneous abortion is emphasized [13][14][15] but this has not been confirmed by other investigators [16]. It has been proposed that a latent endometrial HSV infection may be reactivated and affect the amniochorion and chorionic villi destroying the embryo (blighted ovum) [15].…”

Section: Discussionmentioning

confidence: 89%

“…A correlation between HSV and spontaneous abortions has been reported although the data are mainly epidemiological and controversial [13][14][15][16]. HSV possesses certain clinical properties and specific features which lead some investigators to believe that a significant proportion of the 40% of spontaneous abortions of unknown aetiology may be caused by this virus [15].…”

Section: Introductionmentioning

confidence: 99%

Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Sifakis

Koumantakis

Koffa

et al. 1998

Gynecol Obstet Invest

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Objective: To investigate the contribution of HSV to the aetiopathogenesis of spontaneous abortion. Design: A hospital-based, case-control study. Setting: Department of Obstetrics and Gynecology, University Hospital and Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece. Population and Methods: Abortion material from 102 cases of women with spontaneous abortion was analysed for the presence of HSV DNA applying the PCR technique. Serological assays were used for the detection of specific IgM and IgG antibodies in the maternal sera of 90 pregnant women with successful outcome of their pregnancy while 70 non-pregnant women at reproductive age were also examined as control. Results: The HSV genome was detected by PCR amplification in 3 cases of spontaneous abortion, 2 of them exhibited serological markers of virus reactivation while the 3rd showed a past infection. There were no obvious clinical manifestations indicating a current herpes infection. Both groups of pregnant women, either with spontaneous abortion or with a successful outcome of pregnancy, displayed serological markers of HSV reactivation at higher rates compared with non-pregnant women (χ², p < 0.05). Conclusions: Using the PCR technique we were able to detect the HSV genome in gestational tissues of spontaneous abortions, even in cases without any clinical symptoms or seropositivity for a primary infection. Serological assays were not very useful for the elucidation of the role of HSV in inducing spontaneous abortions, although they indicate that the state of pregnancy predisposes to HSV reactivation. However, the detection of HSV in 3 out of a total number of 102 cases does not support HSV infection as a major abortion-related factor.

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“…Nonoxynol-9 is a potent inactivating agent of HSV in vitro and lias also been shown to act synergistically with human cv-interfcron against HSV in vitro where it was postulated that the nonoxynol-9 destroyed extracellular HSV while the inter feron disrupted intracellular viral replication [15]. How ever, as with other in vitro viricidal agents, nonoxynol-9 has not demonstrated any effect on genital herpes in vivo [16]. The current clinical trial was not designed to eval uate synergy.…”

Section: Introductionmentioning

confidence: 99%

Topical Alpha-Interferon in Recurrent Genital Herpes Simplex Infection

Shupack

Stiller²,

Knobler³

et al. 1990

Dermatology

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We conducted a double-blind placebo-controlled clinical trial on 98 subjects to assess the efficacy of two strengths of topical human leukocyte α-interferon, 10⁴ and 10⁶ IU/g in a 1% nonoxynol-9 base, in the treatment of recurrent genital herpes simplex virus (HSV). The study medication was applied during the prodromal phase or at the first sign of recurrence of the infection. The high-dose α-interferon was found to be significantly more effective than the low-dose interferon and placebo with respect to the duration of viral shedding as well as in reducing the time to the end of all subjective symptoms, including pain, burning and itching. No difference between the three groups was found in times to crusting or healing. Further studies of topical interferon in the treatment of HSV and other viral infections are merited.

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Clinical course and diagnosis of genital herpes simplex virus infection and evaluation of topical surfactant therapy

Cited by 53 publications

References 11 publications

Persistent Stress as a Predictor of Genital Herpes Recurrence

Persistent Stress as a Predictor of Genital Herpes Recurrence

Detection of Herpes simplex Virus (HSV) in Aborted Material Using the Polymerase Chain Reaction Technique

Topical Alpha-Interferon in Recurrent Genital Herpes Simplex Infection

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