Clinical course and outcomes of chronic viral hepatitis D in patients from Republic of Tuva as endemic region

Isaeva, Olga V.; Ильченко, Л. Ю.; Saryglar, Anna A.; Karlsen, Anastasia A.; Кюрегян, К. К.; Михайлов, М. И.

doi:10.36233/0507-4088-29

Cited by 2 publications

(3 citation statements)

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“…Определение у пациентов маркеров HBVи HDV-инфекций проводили с помощью наборов коммерческих диагностикумов производства ЗАО «Вектор-Бест» (Россия): выявление HBsAg выполняли с помощью набора реагентов «HBsAg-ИФА-БЕСТ» с чувствительностью 0,01 МЕ/мл; анти-HDV -с помощью набора «Вектогеп D-антитела»; РНК HDV -с набором «РеалБест РНК ВГD», обладающим порогом детекции 10 копий/мл; ДНК HBV -с набором «РеалБест ДНК ВГВ» с порогом детекции 5 МЕ/мл. Для 58 пациентов определяли генотип HDV методом амплификации участка вирусного генома R0 с последующим секвенированием по описанной ранее методике [8].…”

Section: материалы и методы исследованияunclassified

Clinical and epidemiological characteristics of D hepatitis В and delta in the Republic of Dagestan

Magomedova,

Makashova,

Arbulieva

et al. 2023

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Aim: The analysis of the incidence of hepatitis B in the Republic of Dagestan (RD) and clinical and epidemiological characteristics of HBV/HDV coinfection in the region.Materials and Methods. The dynamics of the hepatitis B incidence rates and the coverage of vaccination against this infection in the RD in 2008-2022 were analyzed based on the data from of the statistical forms of Rospotrebnadzor. The clinical and epidemiological characteristics of delta hepatitis were analyzed in 371 patients under dispensary observation at the Republican Center for Infectious Diseases named after S.-А.М. Magomedov.Results. Over the past 10 years, the incidence of CHB in the RD has increased more than 4.5 times, from 1.4 per 100 thousand population in 2008 to 6.7 per 100 thousand population in 2022. A decrease in the rates of hepatitis B child immunization in the RD is observed since 2009. Hepatitis B vaccination coverage rates in adult population fell sharply after 2010, both in the RD and in the Russian Federation on average. The frequency of HDV co-infection in persons infected with HBV in the RD is 13.8%, but reaches 15% in some regions of the republic, indicating the moderate level of endemicity. Patients with HBV/HDV coinfection are predominantly males aged 25–45 years with advanced fibrosis or cirrhosis. All cases of HDV infection in the RD are caused by viral genotype 1.Conclusions. The obtained results testify to the significance of the problem of hepatitis B and delta in the RD. The number of identified patients and, accordingly, the rate of co-infection, apparently, will increase with the expansion of screening for markers of HDV infection, when patients who were registered as HBsAg carriers will be examined according to the patient routing guidelines. The late diagnosis of delta hepatitis in RD and the limited possibilities of antiviral therapy are another significant issues.

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Section: материалы и методы исследованияunclassified

Clinical and epidemiological characteristics of D hepatitis В and delta in the Republic of Dagestan

Magomedova,

Makashova,

Arbulieva

et al. 2023

jour

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“…Previously, the Republic of Tuva was shown to be endemic for hepatitis B, as the HBsAg detection rate in the general population reached 8% in a serosurvey conducted in 2008, which significantly exceeded HBV prevalence in other regions of Russia 9 . Moreover, preliminary reports indicated high HDV‐associated morbidity in this region 10 . Tuva is in southern Siberia, borders Mongolia to the south, and is the least developed region in Russia, according to the United Nations Human Development Index (HDI) 11 .…”

Section: Introductionmentioning

confidence: 99%

“…9 Moreover, preliminary reports indicated high HDV-associated morbidity in this region. 10 Tuva is in southern Siberia, borders Mongolia to the south, and is the least developed region in Russia, according to the United Nations Human Development Index (HDI). 11 A universal newborn HBV vaccination program was launched in Tuva in 1997, a year earlier than in the rest of the Russian Federation.…”

Section: Introductionmentioning

confidence: 99%

Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination

Isaeva

Kyuregyan

Karlsen

et al. 2022

Journal of Viral Hepatitis

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The hepatitis delta virus (HDV) is believed to be a vanishing infection in countries with successful hepatitis B virus (HBV) vaccination programs. We assessed the current status of HDV infection in Tuva, a region of the Russia that has been highly endemic for HBV. The proportion of HDV‐infected patients among HBsAg‐positive patients in the regional registry in 2020 was 32.7% (786/2401). An analysis of the medical records of 514 HDV patients demonstrated that 37.5% (193/514) had liver cirrhosis at the first doctor's visit, and 7.4% of patients lived in families where another family member had HDV. All HDV patients were infected with genotype HDV‐1, 94.5% had HBV genotype D, and 5.5% had genotype A. A serosurvey conducted among 1170 healthy volunteers showed that the average detection rate of HBsAg with anti‐HDV was 1.0% (95% CI: 0.57–1.81%). No anti‐HDV positive samples were detected in participants aged under 30 years. The HBsAg/anti‐HDV positivity rate peaked at 7.4% in patients aged 50–59 years, which was significantly higher than in a similar age cohort surveyed in 2008 (1.6%, p < .0001). A Bayesian analysis showed that HDV circulation in Tuva resulted from two waves of introduction, the first in the 1810s (95% HPD: 1741–1834) from Central Asia, and the second in the 1960s (95% HPD: 1953–1979) from Russia. HBV has a much longer history of circulation in Tuva with the MRCA for the predominant genotype HBV‐D dated to 972 (95% HPD: 535–1253) for subtype D1, 1274 (95% HPD: 936–1384) for D2, and 1173 (95% HPD: 1005–1618) for D3. A SkyGrid reconstruction of population dynamics showed an increase in the intensity of HDV spread in recent decades. This situation shows the need for HDV screening and prevention measures among people living with HBV.

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Clinical course and outcomes of chronic viral hepatitis D in patients from Republic of Tuva as endemic region

Cited by 2 publications

References 34 publications

Clinical and epidemiological characteristics of D hepatitis В and delta in the Republic of Dagestan

Clinical and epidemiological characteristics of D hepatitis В and delta in the Republic of Dagestan

Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination

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