Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

Aydın, Banu; Zencıroğlu, Ayşegül; Díllí, Dílek; Okumuş, Nurullah; Ipek, Mehmet Sah; Aydın, Mustafa; Uzunaliç, Nuran; Hakan, Nilay; Kundak, Ahmet Afşin; Dursun, Arzu; Karadağ, Nilgün; Korukluoğlu, Gülay

doi:10.5578/tt.4598

Cited by 7 publications

(19 citation statements)

References 30 publications

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“…In previous studies, it was reported that abnormal chest radiography was present in 30 % to 80 % of hospitalized infants with acute viral LRI. 6,14,20,25,26 As it was found in this study, in newborn infants with RSV infection, atelectasis is common findings on chest radiographs, which is associated with prolonged hospital stay and need for respiratory support. 6,27 It has been stated that viral co-infections are more often associated with alveolar pneumonia than single viral infections when other clinical or laboratory parameters could not be distinctive.…”

Section: Discussionmentioning

confidence: 58%

Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center

2019

Arch Argent Pediat

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Aim: To determine the etiological profiles of lower respiratory tract infection (LRI) in neonates during respiratory syncytial virus(RSV) season, and to define the clinical features of RSV-related infection and others. Methods: The retrospective study included newborn infants who were hospitalized for LRI during the two consecutive RSV seasons, and then tested for possible etiological agent by multiplex real-time polymerase chain reaction. All relevant data were reviewed, and the clinical characteristics of RSV-related infection were compared to those of others. Results: Of 224 patients, 160 (71 %) were positive for at least one potentially causative agent. Of them, 65 % had RSV, and 15 % had more than on ecausative agent (co-infection). The RSV group had more the findings of respiratory distress (p< 0.01), abnormal chest radiography (p< 0.01), need for intensive care (p< 0.01), and duration of oxygen requirement (p< 0.01) but less fever on admission and duration of antibiotic use (for both, p< 0.01), and no longer hospital stay. Need of intensive care nursery was more common in patients with co-infection than others (25 % vs. 6.5 %, p< 0.01). Conclusion: This study highlighted that RSV was the most frequent agent in neonates hospitalized for LRI during the season, with a more severe clinical course than other detected pathogens. The disease severity of RSV infection may have seemed to be increased by the presence of coinfection and abnormal chest radiography.

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Section: Discussionmentioning

confidence: 58%

Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center

2019

Arch Argent Pediat

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“…Also, during the neonatal period and infancy right and left ventricular wall thickness are the same. The left to right shunt is small 1 in patients with ASD in this period. During the infancy and early childhood the right ventricular wall becomes thinner and hence more compliant than that of the left ventricle, there is an increase in left-toright shunting.…”

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confidence: 69%

“…To the Editor, With interest we read the article by Aydın et al about "Clinical course of community-acquired respiratory syncytial virus (RSV) pneumonia in newborns hospitalized in neonatal intensive care unit" (1). We have the following comments and concerns.…”

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confidence: 99%

Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

Karademir¹,

Yoldaş²

2017

Tuberk Toraks

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With interest we read the article by Aydın et al. about "Clinical course of community-acquired respiratory syncytial virus (RSV) pneumonia in newborns hospitalized in neonatal intensive care unit" (1). We have the following comments and concerns.The echocardiographic results of the patients were observed in this article. Secundum type atrial septal defect (ASD) has been noted in 7 patients. Four of them has been needed mechanical ventilation support. It has been noted that clinical course of RSV pneumonia was worse in patients with ASD. The authors also noted that ASD might negatively affect the course of the disease with increased viral load in lungs due to increased pulmonary blood flow.RSV is a major cause of pneumonia in infants and young children worldwide (2-4). Pediatricians are using palivizumab prophylaxis in high risk infants to prevent RSV infection during RSV season. According to recommendations of American Academy of Pediatrics, congenital heart disease requiring palivizumab prophylaxis include cyanotic heart diseases, moderate to severe pulmonary hypertension and congestive heart failure requiring medication (5). In your study you think that ASD has been increased the disease severity due to increased pulmonary blood flow. We don't agree your discussion. Because; during fetal life, the majority of the blood reaching the left atrium comes via foramen ovale. Since there is minimal flow to the lungs. After birth, the lungs expand and the pulmonary blood flow begins to increase. The increased pulmonary venous return to the left atrium results in the left atrial pressure exceeding the right atrial pressure causing functional closure of the foramen ovale. Intrauterine physiology is not altered in the presence of an ASD, but ASD does not close with hemodynamic changes that occur following birth. Also, during the neonatal period and infancy right and left ventricular wall thickness are the same. The left to right shunt is small Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

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“…‡ Otros incluyen coinfección con varios agentes (n: 5), adenovirus (n: 1), enterovirus (n: 1), Mycoplasma pneumoniae (n: 1) y Haemophilus influenzae tipo b (n: 1). 25 (23,8) 32 (26,9) 0,646 † El 24 % había sido alimentado con leche maternizada además de la leche materna. ‡ Las afecciones preexistentes incluyen prematurez (≤36,6 semanas, n: 43), antecedentes de displasia broncopulmonar (n: 3), cardiopatías congénitas (comunicación interauricular, comunicación interventricular, conducto arterial persistente, estenosis valvular pulmonar, n: 6) y cirugías por anomalía intestinal (n: 2).…”

Section: Resultsunclassified

“…En estudios previos, se informó que entre el 30 % y el 80 % de los lactantes hospitalizados con IVRB viral aguda tenían hallazgos anormales en la radiografía de tórax. 6,14,20,25,26 Como se observó en este estudio, en los recién nacidos con infección por VSR, la atelectasia es un hallazgo frecuente en las radiografías de tórax, asociada con una prolongación de la hospitalización y la necesidad de asistencia respiratoria. 6,27 Se ha indicado que las coinfecciones virales están más a menudo asociadas con neumonía alveolar que las infecciones virales simples cuando otros parámetros clínicos o de laboratorio no permiten establecer una distinción.…”

Section: Discussionunclassified

Prevalencia de microorganismos patógenos respiratorios durante dos temporadas consecutivas de virus sincicial respiratorio en un centro de atención de alta complejidad

2019

Arch Argent Pediat

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Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

Cited by 7 publications

References 30 publications

Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center

Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center

Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

Prevalencia de microorganismos patógenos respiratorios durante dos temporadas consecutivas de virus sincicial respiratorio en un centro de atención de alta complejidad

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