Clinical course of solitary extramedullary plasmacytoma

Liebross, Robert H.; Ha, Chul S.; Cox, James D.; Weber, Donna M.; Delasalle, Kay; Alexanian, Raymond

doi:10.1016/s0167-8140(99)00114-0

Cited by 247 publications

(214 citation statements)

References 21 publications

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“…Compared to other studies, the median time to progression of 34.3 months we saw in our patients forms the upper end of the reported range of 13 -36 months [1,7,8,9]. Six out of nine patients with progressive disease developed multiple myeloma in the first year after diagnosis.…”

Section: Progression To Multiple Myelomacontrasting

confidence: 61%

Radiotherapy of solitary plasmacytoma

et al. 2011

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International audienceSolitary plasmacytoma of the bone (SBP) or extramedullary plasmacytoma (EP) are rare neoplasms amenable to local radiotherapy. In this retrospective analysis, we report the University Heidelberg experience in the treatment of solitary plasmacytoma. From 1995 to 2008, 18 patients were treated with local radiotherapy. Ten patients suffered from SBP, eight patients showed a single extramedullary lesion. Local radiotherapy with a median dose of 45 Gy yielded excellent local control with only one patient suffering from local relapse. SBP and EP had significantly different 5-year multiple myeloma-free survival rates of 36.8% and 86.7%, respectively. However, no significant difference in overall survival could be detected. Radiotherapy can achieve excellent local control of solitary plasmacytoma. Progression to multiple myeloma, especially in the case of SBP, remains to be addressed by further studies

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Section: Progression To Multiple Myelomacontrasting

confidence: 61%

Radiotherapy of solitary plasmacytoma

et al. 2011

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“…1,2 The large number of patients in this study(n ¼ 84) allowed us to analyze the importance of various clinicopathologic and therapy-related factors in predicting local control or progression to multiple myeloma.…”

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confidence: 99%

Solitary plasmacytomas

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Medeiros

et al. 2011

Cancer

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BACKGROUND:The objective of this study was to review the outcome of patients with solitary plasmacytoma (SP) after definitive radiation therapy. METHODS: The authors retrospectively reviewed 84 patients with SP who were diagnosed and treated at The University of Texas MD Anderson Cancer Center during 1988 to 2008. The impact of tumor anatomic site, tumor size, and the presence of serum and urinary paraprotein at diagnosis was assessed on local control, survival, and the risk of developing multiple myeloma (MM). RESULTS: Fifty-nine patients (70%) had bone SP, and 25 patients (30%) had extramedullary SP. Serum paraprotein was present in 39 patients (46%). The median radiation dose was 45 grays (Gy) (range, 36-53.4 Gy). Local control was achieved in 77 patients (92%). Neither radiation dose nor tumor size predicted local control. The 5-year rate of progression to MM was 47% and was higher for patients with bone SP (56% vs 30% for extramedullary SP; P ¼ .021), and patients who had serum paraprotein detected at diagnosis (60% vs 39%; P ¼ .016). On univariate analysis, patients aged <60 years and men had higher rates of progression to MM, although the differences were not significant (P ¼ .048 and P ¼ .29, respectively). Multivariate analysis revealed that bone location and serum protein at diagnosis were associated statistically with progression to MM. The 5-year overall survival rate for the entire patient cohort was 78%, and no difference was observed between patients who had bone SP versus extramedullary SP (76% vs 85%, respectively; P ¼ .274). CONCLUSIONS: The current results indicated that definitive radiation therapy for SP can provide excellent local control. Progression to MM remains the main problem and is more common among patients with bone SP and those who have serum paraprotein detected at diagnosis. Cancer 2011;117:4468-

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“…EMP is typically presents as a welllocalized submucosal swelling, sometimes with polypoidal configuration. Presenting symptoms of EMP of head and neck are frequently secondary to local destruction and tumor mass [2,[6][7][8].…”

Section: Case Reportmentioning

confidence: 99%

“…In a study by Alexiou et al 16 % of patients with extramedullary plasmacytoma progressed to multiple myeloma [6,7].…”

Section: Case Reportmentioning

confidence: 99%