Clinical Course, Risk Factors, and Treatment of Microcystic Adnexal Carcinoma: A Short Series Report

Abbate, M; Zeitouni, Nathalie C.; Seyler, Marie; Hicks, Wesley L.; Loree, Thom R.; Cheney, Richard

doi:10.1046/j.1524-4725.2003.29296.x

Cited by 60 publications

(108 citation statements)

References 31 publications

(59 reference statements)

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“…Discussion MAC is a rare, primarily cutaneous neoplasm that usually occurs in the face with a predilection for the nasolabial area and periorbital skin [1][2][3][4][5][6]. MAC has historically gone by a variety of names including malignant syringoma, anaplastic syringoma/syringoid carcinoma, sweat gland carcinoma with syringomatous features, and sclerosing sweat duct carcinoma [1][2][3][4].…”

Section: Casementioning

confidence: 99%

“…MAC has historically gone by a variety of names including malignant syringoma, anaplastic syringoma/syringoid carcinoma, sweat gland carcinoma with syringomatous features, and sclerosing sweat duct carcinoma [1][2][3][4]. This entity was first described by Goldstein et al [2] as a potential mimicker of benign adnexal neoplasms such as desmoplastic trichoepithelioma, trichoadenoma, and syringoma.…”

Section: Casementioning

confidence: 99%

“…All cases included areas of extensive but remarkably subtle infiltrationwell illustrated in image (b)-wherein the neoplastic ducts could easily be mistaken for vessels absence of significant solar exposure. Solar radiation has previously been implicated in MACs due to their predilection for the skin of the face, a highly sun-exposed locale [1,4,6,16]. Therapeutic ionizing radiation for other causes, such as acne and carcinoma, has also been suggested as causal in MAC, with reports of MACs arising three to four decades after radiation treatment [17].…”

Section: Casementioning

confidence: 99%

“…Microcystic adnexal carcinoma (MAC) is a rare neoplasm that most often arises in the central facial skin of middleaged and older adults [1][2][3][4][5][6]. It is most common among Caucasians and shows a slight female predominance.…”

Section: Introductionmentioning

confidence: 99%

“…This infiltrative pattern corresponds with their clinical behavior: MACs characteristically show extensive invasion and local destruction and are prone to recurrence. This insidious, locally-aggressive course necessitates lifetime monitoring for and management of recurrence even after resection and therapy [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Mills

Policarpio-Nicholas

Agaimy

et al. 2016

Head and Neck Pathol

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Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52.6 years (range 41-73 years). Location included the tongue (n = 2), the floor of the mouth (n = 2), and the nasopharynx/clivus (n = 1). One occurred after radiation therapy and another occurred in the setting of immune compromise. Immunohistochemistry highlighted a dual cell population with luminal cells showing positivity for high and low-molecular weight keratins and surrounding myoepithelial cells showing S100 and smooth muscle actin staining. No cases had nodal involvement, and the single patient with clinical follow-up was alive and free of disease 34 months after diagnosis and definitive radiochemotherapy. Differential diagnoses for all cases diverged from those provoked by MAC in the skin and included a variety of salivary gland neoplasms such as adenoid cystic carcinoma, polymorphous low grade adenocarcinoma, and mucoepidermoid carcinoma. Recognition of sclerosing microcystic adenocarcinoma in the head and neck mucosa is critical given its bland appearance and subtle infiltration pattern, infrequency of nodal involvement, and behavioral differences from the other entities on the differential.Keywords Sclerosing microcystic adnexal carcinoma Á Microcystic adnexal carcinoma Á MAC Á Head and neck Á Salivary gland carcinoma Á Mucosal

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Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Mills

Policarpio-Nicholas

Agaimy

et al. 2016

Head and Neck Pathol

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Cutaneous Appendageal Carcinoma Incidence and Survival Patterns in the United States

Blake¹,

Bradford²,

Devesa³

et al. 2010

Arch Dermatol

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Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

Worley

Owen²,

Barker

et al. 2019

JAMA Dermatol

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IMPORTANCE Microcystic adnexal carcinoma (MAC) occurs primarily in older adults of white race/ethnicity on sun-exposed skin of the head and neck. There are no formal guiding principles based on expert review of the evidence to assist clinicians in providing the highest-quality care for patients. OBJECTIVE To develop recommendations for the care of adults with MAC.EVIDENCE REVIEW A systematic review of the literature (1990 to June 2018) was performed using MEDLINE, Embase, Web of Science, and the Cochrane Library. The keywords searched were microcystic adnexal carcinoma, sclerosing sweat gland carcinoma, sclerosing sweat duct carcinoma, syringomatous carcinoma, malignant syringoma, sweat gland carcinoma with syringomatous features, locally aggressive adnexal carcinoma, and combined adnexal tumor. A multidisciplinary expert committee critically evaluated the literature to create recommendations for clinical practice. Statistical analysis was used to estimate optimal surgical margins.

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Clinical Course, Risk Factors, and Treatment of Microcystic Adnexal Carcinoma: A Short Series Report

Abstract: This report supports the use of Mohs micrographic surgery for tumor control with the least possible procedures. Risk factors appear to include radiation treatment, ultraviolet exposure, and possibly genetics.

Cited by 60 publications

References 31 publications

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Cutaneous Appendageal Carcinoma Incidence and Survival Patterns in the United States

Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

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