2023
DOI: 10.1038/s41598-023-45006-5
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Clinical courses of acute kidney injury in hospitalized patients: a multistate analysis

Esra Adiyeke,
Yuanfang Ren,
Ziyuan Guan
et al.

Abstract: Persistence of acute kidney injury (AKI) or insufficient recovery of renal function was associated with reduced long-term survival and life quality. We quantified AKI trajectories and describe transitions through progression and recovery among hospitalized patients. 245,663 encounters from 128,271 patients admitted to UF Health between 2012 and 2019 were retrospectively categorized according to the worst AKI stage experienced within 24-h periods. Multistate models were fit for describing characteristics influe… Show more

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“…An observational analysis showed similar results that severe COVID-19 only significantly affected the risk of incident acute kidney disorder in the first week, but not in the next 3 weeks. Consistent with previous studies, patients with no AKI diagnosis had the highest transition rates to stage 1 AKI within the first week during the whole intensive care unit stay [ 39 ]. The incidence rate of AKI in patients with severe COVID-19 ranges from 41% to 62% [ 6 8 ], and most cases are classified as transient AKI that rapidly develops within the first week after SARS-CoV-2 infection [ 40 , 41 ].…”
Section: Discussionsupporting
confidence: 89%
“…An observational analysis showed similar results that severe COVID-19 only significantly affected the risk of incident acute kidney disorder in the first week, but not in the next 3 weeks. Consistent with previous studies, patients with no AKI diagnosis had the highest transition rates to stage 1 AKI within the first week during the whole intensive care unit stay [ 39 ]. The incidence rate of AKI in patients with severe COVID-19 ranges from 41% to 62% [ 6 8 ], and most cases are classified as transient AKI that rapidly develops within the first week after SARS-CoV-2 infection [ 40 , 41 ].…”
Section: Discussionsupporting
confidence: 89%