Clinical, Demographical Features, Accompanying Diseases and Neutrophil to Lymphocyte Ratio- Platelet to Lymphocyte Ratio in Patients with Bullous Pemphigoid in Bolu

Abstract

Bullous pemphigoid (BP) is a rare autoimmune blistering disorder that affects the elderly population. In this study, we retrospectively evaluated the clinical, demographic characteristics and comorbid diseases in patients with BP. Mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are known to be the indicators of inflammation. We also investigated MPV, NLR, and PLR values in patients with BP and a control group. To our knowledge, there is no previous study in the literature researching NLR, PLR and MPV together in patients with BP. Method: A total of fourteen patients with BP and fourteen control subjects were included in the study. Medical reports of the patients who received clinical and histopathological diagnosis of BP between 2008 and 2018 were reviewed. MPV, NLR, and PLR values were recorded in BP patients and the control group. Results: Of the 14 patients, 9 were female and 5 male. The most frequent comorbid chronic disease was hypertension, which was detected in 7 (50%) patients. Four of the 7 patients with hypertension had coronary artery disease (28,5%) at the same time. The NLR of patients with BP was significantly higher than that of the control group (p = 0.01). There was no difference in PLR and MPV between the groups. Conclusions: The most common comorbidity in patients with BP in our study was cardiovascular diseases. More studies are needed to investigate the association between BP and cardiovascular disorders. In addition, NLR may be an inexpensive and simple parameter of inflammation in patients with BP and needs to be developed further.

Hematological Inflammatory Markers in Patients with Pemphigus Vulgaris

“…The NLR was also found to be positively correlated with disease activity in rheumatoid arthritis, gouty arthritis, Sjögren's syndrome, familial Mediterranean fever, osteoarthritis, and other diseases [20,[35][36][37][38]]. An elevated NLR has been observed in patients with the dermatological disorders such as bullous pemphigoid [30], psoriasis [27], lichen planus [28], and atopic dermatitis compared to control groups [39]. Elevated NLR in psoriasis was also positively correlated with the Psoriasis Area and Severity Index (PASI) score and was described as a possible predictor for psoriatic arthritis [40].…”

“…These include rheumatic diseases such as rheumatoid arthritis, lupus erythematosus, fibromyalgia [17,20,21], several types of vasculitides [22][23][24], cardiovascular diseases [25], malignancies [26], inflammatory skin disorders including psoriasis [27] and lichen planus [28]. The NLR and MPV were also described as possible markers of inflammation in bullous pemphigoid [29,30]. Two retrospective studies demonstrated that the NLR and PLR rates were higher in PV patients than in controls but were not related to disease severity and course [31,32].…”

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are positively correlated with disease activity of bullous pemphigoid

“…In 2018, Ozer et al [39] proved that the NLR levels of 26 untreated BP patients were signi cantly higher than that of age-and gender-matched 25 nonin ammatory dermatosis controls (p = 0.04). Similarly, in 2019, Sere ican et al [40] veri ed that the NLR levels of 14 untreated BP patients were signi cantly higher than that of age-and gender-matched 14 non-in ammatory dermatosis controls (p = 0.01).…”