Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review

Hung, Kuo-Hsuan; Hsiao, Ching-Hsi; Tan, Hsin-Yuan; Chen, Hung-Chi; Hui‐Kang, David; Lin, Hsin-Chiung; Yeh, Lung‐Kun

doi:10.1007/s10792-020-01347-y

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…However, no combined surgery is considered to be the best choice nowadays. Conjunctival transplantation usually takes the conjunctival tissue at the upper limbus, which has the advantage of direct and complete component transplantation, and prevents the proliferation and migration of the diseased conjunctiva through healthy conjunctival tissue [14][15][16]. e transplantation will bring regional damage to the upper conjunctiva, which will not only affect the local microenvironment stability and form tissue scar repair but also have a great adverse impact on glaucoma surgery.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium

Chen

Zheng

Zhang

et al. 2022

Contrast Media & Molecular Imaging

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Objective. The aim of the study is to evaluate the safety and effectiveness of amniotic membrane transplantation combined with the closure of the tenon capsule and bulbar conjunctival space. Methods. This study retrospectively included 100 patients with primary pterygium who received closed bulbar conjunctiva and tenon capsule space combined with amniotic membrane transplantation in our hospital from January 2020 to June 2021 as the experimental group and 100 patients with routine treatment in the same period as the control group. The postoperative efficacy evaluation and postoperative complications of the two groups were compared, so as to comprehensively evaluate the safety and effectiveness of this method. Results. The results showed that the postoperative complications of the two groups were significantly improved by Fisher’s exact test (χ2 = 14.510, P = 0.006 < 0.05). The comparison results showed that the treatment group showed significant advantages in six indexes compared with the observation group and the difference between the two groups was statistically significant (P < 0.05) of in the NRS score, Prabhasawat score, inspection of the ocular surface comprehensive analyzer, corneal fluorescein staining, conjunctival fluorescein staining in the operation area, breakup time of tear film examination of the two groups at 3, 7 and 14 days, and 1, 6 and 12 months after the operation. Conclusions. Amniotic membrane transplantation combined with the closure of the tenon capsule and bulbar conjunctival space is safer than conventional surgery in the treatment of primary pterygium. It has a shorter recovery time, higher safety, and a positive curative effect. It can be considered to popularize this operation in clinic.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium

Chen

Zheng

Zhang

et al. 2022

Contrast Media & Molecular Imaging

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“…Many techniques have been proposed with variable recurrence rates 11 . A recent review of the literature and a meta-analysis found that the recurrence rate for conjunctival autografts ranges from 2% to 39% 12 . There are 2 studies comparing the incidence of recurrences between consultant surgeons and trainees.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Involved in Recurrence of Pterygium Excision after Surgical Excision

Waseem¹,

Bhatti²,

Khan³

et al. 2022

PJMHS

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Aim: To determine the effect of the type and size of growth, sex and patients age, and the application of mitomycin-C intraoperatively and its application duration effect on pterygium recurrence afterwards excision. Study Design: A retrospective and descriptive case series. Place and Duration: In Alshifa Trust Eye Hospital, Rawalpindi and the department of Ophthalmology CMH, Lahore for the duration from November 2022 to April 2022. Methods: Data files from 80 patients (80 eyes) who underwent bare sclera technique surgery with MMC at 0.2 mg / ml (0.02%) and application time ranging from 1 to 5 mints. The study included 60 males and 20 females with 46.4 years of mean age (16 to 60 years). Cases were classified according to sex, age, pterygium type and size and MMC application time. The main outcome measures were to compare the eye affected by the pterygium for any type of recurrence after at least 1-year of follow-up. Results: In our case series, the rate of pterygium recurrence was 10% in the mean follow-up of 1 year. The influencing factors like younger age at admission (<50 years), secondary pterygium (p = 0.330) was suggestively related with pterygium recurrence. There was a clear tendency of less rate of recurrence with smaller pterygium size, with MMC administration times greater than 3 minutes. However, it was not possible to obtain statistical significance due to the smaller sample size. Conclusions: This study results propose that younger age < 50-years, a history of multiple recurrences, increased size and a duration of MMC administration < 3 mints are risk factors for postoperative recurrence of pterygium

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“…In OSSN cases in young patients, there is an established association with HIV, much more evident in Africa than elsewhere, which is why we should always discard HIV in any patient younger than 40 years with OSSN 17 ; our HIV-positive patients with OSSN was 29 years old at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] The ocular surface squamous neoplasia (OSSN) is the most frequent ocular tumor, 13,14 with a variable incidence between 0.5% and 1.8% of the general population 15,16 ; the term comprises a wide range of epithelial neoplastic lesions of the cornea and conjunctiva, ranging from mild dysplasia, passing through Ca in situ, up to invasive squamous cell carcinoma. These lesions are typically of interpalpebral location, where there is greatest UV radiation exposure, and a strong relationship to human papilloma virus and HIV (human immunodeficiency virus) 17 has also been described.…”

mentioning

confidence: 99%

An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report

Mejía

Zapata

Gil

2020

Cornea

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To report the unexpected finding of ocular surface neoplasia (OSSN) on conjunctival tissue removed during pterygium surgery and subjected to histopathology analysis.Methods: This is an observational, descriptive retrospective study in which all the samples removed during surgery between 1997 and 2020 with a clinical diagnosis of pterygium were sent for histopathology analysis in which an unexpected OSSN was found.Results: There were 461 cases with a preoperative diagnosis of pterygium, with a mean age of 30.14 6 10.6 years. In this group, there was an unexpected finding of OSSN in 69 cases (14.96%) of the surgical samples, with a mean age of 46 6 8.2 years (31.86 6 12.13). Conclusions:The unexpected coincidence of pterygium and OSSN is frequent, although varies depending on the geographical location. We recommend performing a histopathology analysis on every pterygium removed.

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Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review

Cited by 10 publications

References 25 publications

[Retracted] Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium

[Retracted] Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium

Risk Factors Involved in Recurrence of Pterygium Excision after Surgical Excision

An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report

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