Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

Ezenwosu, Osita U; Chukwu, BF; Ezenwosu, Ifeyinwa L; Uwaezuoke, Ndubuisi A; Eke, Christopher Bismarck; Udorah, Maria; Idoko, Chinedu A.; Ikefuna, AN; Emodi, IJ

doi:10.1186/s12887-021-03015-1

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…O paciente com AF necessita adaptar-se a hábitos de vida que se diferenciam da população geral, principalmente devido ao uso continuado de medicamentos e das constantes internações hospitalares, sendo que crianças e adolescentes que têm hemoglobinopatia necessitam reduzir as horas dispensadas à escola e às atividades produtivas (Ezenwosu et al, 2021).…”

Section: Introductionunclassified

Elaboração de um livro infantil para conversar sobre Anemia Falciforme

Alegre

Santos

Silva-Pinto

et al. 2022

RSD

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Anemia Falciforme (AF) é uma doença hematológica, genética e crônica, que muitas vezes requer hospitalizações e exige atendimento ambulatorial constante. O objetivo deste estudo é descrever as etapas de elaboração de um livro com o propósito de encorajar conversas com crianças com AF sobre a doença, explicando seu funcionamento, sintomatologia e limitações acarretadas no cotidiano. Foram seguidas as seguintes etapas: a) elaboração do projeto, b) seleção de conteúdos, por meio de revisão da literatura sobre sintomatologia e limitações decorrentes da AF; c) elaboração da história: escolha da escola como cenário e da personagem Amanda, uma menina preta, como protagonista do livro; d) elaboração do livro piloto; e) revisão e validação por especialistas: o material foi analisado por psicólogos e médicos com experiência no assunto e crianças sem diagnóstico clínico; f) adequação da linguagem e conteúdos: foram realizadas as adaptações sugeridas; g) nova submissão do material aos especialistas; h) finalização do livro: o material foi ilustrado, catalogado e impresso. Os principais tópicos abordados na história foram: necessidade de eventuais faltas na escola, restrições de atividades físicas escolares, definições da doença, crise, sintomas e tratamento. O enredo encerra com a possibilidade de inserir o paciente com AF em uma rotina adaptada na escola e com dicas para pais e professores. O material produzido poderá ser utilizado em diversos contextos, como na saúde e na escola. Além do caráter educativo, o livro poderá ser usado como material intermediário facilitador para a expressão afetiva das crianças com AF que se identificaram com a vivência da personagem Amanda. (Apoio: Programa Unificado de Bolsas da Universidade de São Paulo - PUB-USP).

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Section: Introductionunclassified

Elaboração de um livro infantil para conversar sobre Anemia Falciforme

Alegre

Santos

Silva-Pinto

et al. 2022

RSD

View full text Add to dashboard Cite

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Internalizing Symptoms in Adolescents With Sickle Cell Disease

Heitzer

Longoria

Porter

et al. 2022

Journal of Pediatric Psychology

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Objective Sickle cell disease (SCD) is a genetic blood disorder that may affect patients’ mood and behavior. However, measuring the prevalence of internalizing symptoms (anxiety and depression) in patients with SCD has been elusive. We assessed internalizing symptoms in adolescents with SCD to evaluate prevalence and to test whether neurocognitive performance and frequency of pain-related episodes were associated with internalizing concerns. Methods One hundred eighty-five patients (57% HbSS/HbSß0-thalassemia, 43% HbSC/HbSß+-thalassemia), ages 12–18 years, received a neuropsychological evaluation as a part of a larger cohort study. Internalizing symptoms were measured using the Behavior Assessment System for Children, Second or Third Edition. Scores on the depression and anxiety scales were compared to normative values using Wilcoxon signed rank test. Spearman correlations examined associations between neurocognitive performances and internalizing symptoms. Robust multivariable regression models measured associations between internalizing symptoms and age, sex, sickle genotype, total hemoglobin, fetal hemoglobin, socioeconomic status, and frequency of pain episodes. Results Parent- and self-reported ratings of internalizing symptoms were not elevated compared to normative expectations. Overall, 1.8% and 6.3% of the sample displayed clinically elevated symptoms of anxiety and depression based on self-report, respectively. There were no associations between internalizing symptoms and neurocognitive performance (all p > .05). In multivariable analyses, the frequency of pain episodes was positively associated with self-reported anxiety (p = .006) and parent-reported depressive symptoms (p = .017). Conclusions Adolescents with SCD do not report elevated internalizing symptoms compared to normative expectations. Further research is needed to examine the trajectory of internalizing symptoms and the bidirectional relationship between pain and psychosocial functioning in SCD.

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Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

Elenga,

Lony,

Mafemamissindu

et al. 2024

Depression and Anxiety

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Importance: While the prevalence and impact of depression have been widely described in sickle cell disease, its relationship with precariousness has never been studied.Objective: This study aimed to describe the prevalence of depression and its relationship with clinical and demographic factors including social precariousness in children with sickle cell disease in French Guiana.Methods: We included children aged 12–18 years with sickle cell disease from the Sickle Cell Reference Center in French Guiana. A simple depression questionnaire “Child depression inventory 2” was proposed and completed by a clinical examination and consultation by a psychologist. Using the known assessment of health inequalities and poverty in health screening centres (EPICES) score, we developed a composite precariousness score that uses five items (each item is scored from 0 to 2). According to the chosen items, precariousness was defined as a score ≥5.Results: The prevalence of depression was 42.5% [95% CI: 31.5–54]. The median age was 15 years [95% CI: 13–17]. The age distribution peaked at 14 years in patients with depression. There were 76% of precarious patients in the depressed group and 18% in the control group (p < 0.0001). In multivariate analysis, genotype SC (OR = 7.66, [1.17; 50.13], p = 0.0338) and precariousness (OR = 15.68, [4.73; 51.94], p < 0.0001) were associated with higher rates of depression. Baseline hemoglobin levels (OR = 0.48, [0.27; 0.88], p = 0.0173) were also associated with lower rates of depression.Conclusions and Relevance: Despite free healthcare, precariousness is an independent risk factor for depression.

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Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

Cited by 6 publications

References 26 publications

Elaboração de um livro infantil para conversar sobre Anemia Falciforme

Elaboração de um livro infantil para conversar sobre Anemia Falciforme

Internalizing Symptoms in Adolescents With Sickle Cell Disease

Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

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