Clinical, Dermoscopic, and Histological Characteristics of Melanoma Patients According to the Age Groups: A Retrospective Observational Study

Abstract

Background: Although the role of melanoma risk factors is well documented, their correlation with patients’ age is less frequently analyzed. Method: The analysis was performed among 189 melanoma patients in different age groups, including <30 years, 31–60 years, and >60 years, to investigate the risk factors, topography, and coexistence of morphological features of 209 melanomas (dermoscopic and histopathological). Results: Among the youngest age group, no correlation with the presence of estimated risk factors was found. The most common dermoscopic pattern was spitzoid and multicomponent asymmetric. The group of middle-aged patients was the most diverse in terms of the occurrence of risk factors, solar lentiginosis, dermoscopic patterns, topography, histological subtypes, and invasiveness of melanomas. The oldest group characterized a strong correlation between solar lentiginosis, NMSC comorbidity, the prevalence of facial melanomas, the dermoscopic pattern of melanoma arising on chronic sun-damaged skin, and regression. Conclusion: The findings regarding the presence of age-specific features in melanoma patients, especially in the youngest and middle-aged groups, might be helpful for clinicians and to target secondary prevention efforts.

The correlation between the MYBL2/CDCA8 signaling pathway of malignant melanoma

“…Recently, there has been a consistent escalation in the global occurrence of MM, imposing a huge economic burden on society [ 17 , 18 ]. Early surgical excision is the primary treatment approach for non-metastatic cutaneous malignant melanoma, yielding favorable survival outcomes [ 19 , 20 ]. In recent years, despite the significant shift in treatment approach for advanced melanoma through the use of targeted therapy and immunotherapy, the risk of mortality in metastatic melanoma remains very high [ 21 ].…”