Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy

Likoff, Mariell J.; Chandler, Sheryl L.; Kay, H. D.

doi:10.1016/0002-9149(87)91183-0

Cited by 414 publications

(18 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fundamentally, it is the intricate interplay of the heart and lung function that determines clinical outcomes among patients with LVSD. Cardiopulmonary exercise testing, which comprehensively measures the expiratory ventilation, pulmonary gas exchange, and cardiac output is one of the best predictors of adverse clinical outcomes for patients with chronic heart failure supporting the critical role of heart and lung interaction in heart failure pathophysiology 43, 44, 45, 46, 47, 48. Our cohort consisted of community‐dwelling older adults without history of heart failure.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS)

Waheed

Chaves

Gardin

et al. 2015

JAHA

View full text Add to dashboard Cite

BackgroundImpaired pulmonary function (IPF) and left ventricular systolic dysfunction (LVSD) are prevalent in the elderly and are associated with significant morbidity and mortality. The main objectives of this study were to examine the relative impact and joint association of IPF and LVSD with heart failure, cardiovascular mortality and all‐cause mortality, and their impact on risk classification using a continuous net reclassification index.Methods and ResultsWe followed 2342 adults without prevalent cardiovascular disease (mean age, 76 years) from the Cardiovascular Health Study for a median of 12.6 years. LVSD was defined as LV ejection fraction <55%. IPF was defined as: forced expiratory volume in 1 second:forced vital capacity <70%, and predicted forced expiratory volume in 1 second <80%. Outcomes included heart failure hospitalization, cardiovascular mortality, all‐cause mortality, and composite outcome. LVSD was detected in 128 subjects (6%), IPF in 441 (19%) and both in 38 (2%). Compared to those without LVSD or IPF, there was a significantly increased cardiovascular risk for groups of LVSD only, IPF only, and LVSD plus IPF, adjusted hazard ratio (95% CI) 2.1 (1.5–3.0), 1.7 (1.4–2.1), and 3.2 (2.0–5.1) for HF; 1.8 (1.2–2.6), 1.4 (1.1–1.8), and 2.8 (1.7–4.7) for cardiovascular mortality; 1.3 (1.0–1.8), 1.7 (1.4–1.9), and 2.1 (1.5–3.0) for all‐cause mortality, and 1.6 (1.3–2.1), 1.7 (1.5–1.9), and 2.4 (1.7–3.3) for composite outcome, respectively. Risk classification improved significantly for all outcomes when IPF was added to the adjusted model with LVSD or LVSD to IPF.ConclusionsWhile risk of cardiovascular outcomes was the highest among elderly with both LVSD and IPF, risk was comparable between subjects with IPF alone and those with LVSD alone. This observation, combined with improved risk classification by adding IPF to LVSD or LVSD to IPF, underscore the importance of comprehensive heart and lung evaluation in cardiovascular outcome assessment.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS)

Waheed

Chaves

Gardin

et al. 2015

JAHA

View full text Add to dashboard Cite

show abstract

“…[4] ICM is associated with worse prognosis than other non-ischemic types of DCM, probably because of the added risk of ischemic events to the existing DCM. [5] It often follows anterior wall MI and to a smaller extent inferior wall MI, which produces left ventricle remodeling with a drop in ejection fraction. Congestive heart failure, particularly left sided, along with fatigue and weakness are the major symptoms.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management of emergency laparotomy in a case of ischemic cardiomyopathy with COPD

Bharati

Singh

2013

Anesth Essays Res

View full text Add to dashboard Cite

Anesthesia for non-cardiac surgeries in patients with ischemic cardiomyopathy with other co-morbidities is a challenging situation for anesthetists. The choice of anesthesia and anesthetic agents should be judicious and balanced to maintain optimum cardiac output and to avoid myocardial depression for a successful postoperative outcome. Here, we describe the anesthetic management for emergency exploratory laparotomy in a patient who was suffering from ischemic cardiomyopathy along with chronic obstructive pulmonary disease and was presented to the emergency operation theater for gastrointestinal tract perforation.

show abstract

“…The major predictors of early cardiovascular death in heart failure are primarily related to ventricular function, clinical status, and ventricular dysrhythmias (table 1) [1, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44]. Various parameters of each of these major categories have been reported to represent the best index of survival (for example, left ventricular stroke work, protodiastolic gallop, frequency of ventricular ectopic beats; see table 1).…”

Section: The Mortality Of Heart Failurementioning

confidence: 99%

The Problem of Ventricular Dysrhythmias and Sudden Death Mortality in Heart Failure: The Impact of Current Therapy

Leier¹,

Alvarez²,

Binkley³

2000

Cardiology

View full text Add to dashboard Cite

Congestive heart failure (CHF), one of the few cardiovascular conditions increasing in incidence and prevalence, is characterized by high morbidity and mortality. Up to 50% of the mortality is attributable to dysrhythmic sudden death. Risk stratification to identify those most susceptible to sudden death remains imperfect. The advances in CHF therapeutics and management over the past 16 years have had a favorable impact on CHF mortality including sudden death. The role of amiodarone and implantable cardioverter-defibrillator intervention is evolving and discussed in the context of current CHF management and available trials.

show abstract

Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy

Cited by 414 publications

References 29 publications

Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS)

Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS)

Anesthetic management of emergency laparotomy in a case of ischemic cardiomyopathy with COPD

The Problem of Ventricular Dysrhythmias and Sudden Death Mortality in Heart Failure: The Impact of Current Therapy

Contact Info

Product

Resources

About