Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs

Ferguson, Heidi; Fréchet, Jean M. J.; Szoka, Francis C.

doi:10.1002/wnan.1209

Cited by 46 publications

(48 citation statements)

References 67 publications

(64 reference statements)

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“…Despite initial responses, cisplatin resistance often results in therapeutic failure. An intense research has been conducted on several mechanisms that account for the cisplatin resistance and various challenges have been made to overcome [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex

Lee

Chae

Kim

et al. 2015

Journal of Controlled Release

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Section: Introductionmentioning

confidence: 99%

Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex

Lee

Chae

Kim

et al. 2015

Journal of Controlled Release

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“…Due to the combined impact of cancer together with adverse side effects of many conventional chemotherapeutic agents, a significant effort is devoted to the design of nanoparticle vectors for cancer therapy [8–10]. Concerning CPT, attempts to improve its solubility and stability by means of nano-formulations cover a wide range of organic nanomaterials [11–19]. Noticeably, a cyclodextrin-containing polymer–CPT nano-formulation is currently undergoing phase II clinical trials [20].…”

Section: Introductionmentioning

confidence: 99%

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

Castillo¹,

Mata²,

Casula³

et al. 2014

Beilstein J. Nanotechnol.

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SummaryCamptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded into iron oxide superparamagnetic nanoparticles with an average size of 14 nm. It was found that surface modification of the nanoparticles by polyethylene glycol enables loading a large amount of camptothecin. While the unloaded nanoparticles do not induce apoptosis in the H460 lung cancer cell line, the camptothecin-loaded nanoparticle formulations exhibit remarkable pro-apoptotic activity. These results indicate that camptothecin retains its biological activity after loading onto the magnetic nanoparticles. The proposed materials represent novel materials based on naturally occurring bioactive molecules loaded onto nanoparticles to be used as chemotherapeutic formulations. The procedure seems apt to be extended to other active molecules extracted from natural products. In addition, these materials offer the potential of being further implemented for combined imaging and therapeutics, as magnetic nanoparticles are known to be multifunctional tools for biomedicine.

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“…17,25 Vesicles, large bio-inspired nanoscale assemblies, 26 have been of interest in CDDP delivery systems mainly in the form of drug-loaded, self-assembling, lipid-based vesicles (liposomes). [27][28][29] In contrast to micelles, vesicles contain a hydrophobic membrane and an aqueous cavity that allow for versatile drug transport properties and -due to their larger structure -encapsulation of a larger amount of drugs compared to micelles, thus allowing for smaller amounts of drug delivery vehicles to be administered whilst achieving similar drug doses. 30 Vesicles, like other nanoparticle systems, are able to passively target tumour cells by exploiting the leaky vasculature at tumour sites, commonly known as the enhanced permeability retention (EPR) effect.…”

mentioning

confidence: 99%

Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery

Shirbin

Ladewig

et al. 2015

Biomacromolecules

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Novel cisplatin (CDDP)-loaded, polypeptide-based vesicles for the targeted delivery of cisplatin to cancer cells have been prepared. These vesicles were formed from biocompatible and biodegradable maleimide-poly(ethylene oxide)114-b-poly(L-glutamic acid)12 (Mal-PEG114-b-PLG12) block copolymers upon conjugation with the drug itself. CDDP conjugation forms a short, rigid, cross-linked, drug-loaded, hydrophobic block in the copolymer, and subsequently induces self-assembly into hollow vesicle structures with average hydrodynamic diameters (Dh) of ∼ 270 nm. CDDP conjugation is critical to the formation of the vesicles. The reactive maleimide-PEG moieties that form the corona and inner layer of the vesicles were protected via formation of a reversible Diels-Alder (DA) adduct throughout the block copolymer synthesis so as to maintain their integrity. Drug release studies demonstrated a low and sustained drug release profile in systemic conditions (pH = 7.4, [Cl(-)] = 140 mM) with a higher "burst-like" release rate being observed under late endosomal/lysosomal conditions (pH = 5.2, [Cl(-)] = 35 mM). Further, the peripheral maleimide functionalities on the vesicle corona were conjugated to thiol-functionalized folic acid (FA) (via in situ reduction of a novel bis-FA disulfide, FA-SS-FA) to form an active targeting drug delivery system. These targeting vesicles exhibited significantly higher cellular binding/uptake into and dose-dependent cytotoxicity toward cancer cells (HeLa) compared to noncancerous cells (NIH-3T3), which show high and low folic acid receptor (FR) expression, respectively. This work thus demonstrates a novel approach to polypeptide-based vesicle assembly and a promising strategy for targeted, effective CDDP anticancer drug delivery.

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Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs

Cited by 46 publications

References 67 publications

Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex

Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery

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