Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy

You, Guoxiang; Sha, Zhiyi; Jiang, Tao

doi:10.3389/fonc.2020.550353

Cited by 16 publications

(23 citation statements)

References 56 publications

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“…These alterations of gray matter induce the pathways of information conveying disruption. However, different from idiopathic epilepsy, preoperative GRE was a relatively short-term symptom, since the glioma is being removed as soon as possible once the GRE appears, and most of GRE onset will be controlled ( 1 ). Hence, our findings that the shortest path length decreased and global efficiency increased in the GRE group were conversely to idiopathic epilepsy.…”

Section: Discussionmentioning

confidence: 99%

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Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy

Sun

Weng

et al. 2022

Front. Oncol.

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BackgroundGlioma-related epilepsy (GRE) is a common symptom in patients with prefrontal glioma. Epilepsy onset is associated with functional network alterations. This study investigated alterations of functional networks in patients with prefrontal glioma and GRE.MethodsSixty-five patients with prefrontal lobe gliomas were retrospectively assessed and classified into GRE and non-GRE groups. Additionally, 25 healthy participants were enrolled after matching for general information. Imaging data were acquired within 72 h in pre-operation. The sensorimotor network was used to delineate alterations in functional connectivity (FC) and topological properties. One-way analysis of variance and post-hoc analysis with Bonferroni correction were used to calculate differences of FC and topological properties.ResultsAll significant alterations were solely found in the sensorimotor network. Irrespective of gliomas located in the left or right prefrontal lobes, the edge between medial Brodmann area 6 and caudal ventrolateral Brodmann area 6 decreased FC in the GRE group compared with the non-GRE group [p < 0.0001 (left glioma), p = 0.0002 (right glioma)]. Moreover, the shortest path length decrease was found in the GRE group compared with the non-GRE group [p = 0.0292 (left glioma) and p = 0.0129 (right glioma)].ConclusionsThe reduction of FC between the medial BA 6 (supplementary motor area) and caudal ventrolateral BA 6 in the ipsilateral hemisphere and the shortening of the path length of the sensorimotor network were characteristics alterations in patients with GRE onset. These findings fill in the gap which is the relationship between GRE onset and the alterations of functional networks in patients with prefrontal glioma.Significance StatementGlioma related epilepsy is the most common symptom of prefrontal glioma. It is important to identify characteristic alterations in functional networks in patients with GRE. We found that all significant alterations occurred in the sensorimotor network. Moreover, a decreased FC in the supplementary motor area and a shortening of the path’s length are additional characteristics of glioma-related epilepsy. We believe that our findings indicate new directions of research that will contribute to future investigations of glioma-related epilepsy onset.

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Section: Discussionmentioning

confidence: 99%

“…Tumor locations and low-grade glioma are susceptible factors for patients with glioma-related epilepsy (GRE) ( 1 , 2 ). However, why prefrontal glioma is frequently induced GRE was still unknown.…”

Section: Introductionmentioning

confidence: 99%

Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy

Sun

Weng

et al. 2022

Front. Oncol.

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“…Epileptic seizures often present as the first clinical symptom of brain tumors and probably the most common presentation of such diseases [ 43 , 44 ]. To properly frame the diagnostic process of seizures, in order to distinguish between idiopathic or glioma-related epilepsy, it is necessary to perform a comprehensive history-taking, detailed physical examination and the most suitable imaging [ 45 ] within the assessment of patients complaining of TOS-like symptoms. Unfortunately, the etiology of seizures, similar to most of the red flags [ 46 ], is tough and often manifold to identify among acute or remote causes [ 47 ], but brain tumors as glioblastomas, which are the most common malignant type of CNS tumor [ 14 ], commonly determine such episodes [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

A Thoracic Outlet Syndrome That Concealed a Glioblastoma. Findings from a Case Report

Storari¹,

Signorini

Barbari³

et al. 2021

Medicina

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Background: Glioblastoma is the most frequent and aggressive malignant brain tumor among adults. Unfortunately, its symptoms can vary considerably depending on the size, location and the anatomic structures of the involved brain. Case report: A 58-year-old male amateur cyclist who suffered from sharp arm pain was examined for a thoracic outlet syndrome due to a previous clavicle fracture. Because of ambiguous results of the neck and nerve plexus imaging, he was referred to a neurosurgeon who properly suspected a brain tumor. The neuroimaging of the brain shown a 3 cm disploriferative mass with a blood enhancement within the left parietal lobe. The mass was urgently removed, and its histologic analysis stated a grade 4 glioblastoma. Conclusion: This case report highlights the differential diagnosis process and the teamwork approach needed to diagnose a rare presentation of a brain glioblastoma, which started its symptoms mimicking a thoracic outlet syndrome caused by a previous bone fracture.

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“…The current standard treatment for LGG is aggressive surgical operation and postoperative chemotherapy and radiotherapy [12]. In recent years, with the development of immunotherapy, targeted therapy and tumor electric field therapy, active comprehensive treatment has improved; however, the 10-year survival rate of cases is still less than 50% and more than half of LGG patients develop therapy-resistant advanced aggressive glioma over time, with depressing prognosis [13]. Previous studies have suggested that ferroptosis is involved in the occurrence and prognosis of glioma.…”

Section: Introductionmentioning

confidence: 99%

Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma

et al. 2022

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Background Low-grade glioma (LGG) is susceptible to ferroptosis, which is involved in TMZ resistance. Ferroptosis induction can enhance the sensitivity to TMZ and synergistically kill glioma cells. T cell-promoted tumor ferroptosis is a vital anti-tumor mechanism of immune checkpoint inhibitors. The SAT1 activation is closely related to ferroptosis upon ROS induction due to the upregulation of arachidonate 15-lipoxygenase (ALOX15) expression. Methods The expression of SAT1 in pan-cancer and corresponding normal tissue from the TCGA data portal was primarily explored. The landscape of SAT1 and immune cell infiltration and their corresponding gene marker sets in different tissues were further explored. Additionally, we evaluated the relationships between SAT1 and the clinicopathologic parameters of LGG, and the disease-specific survival (DSS), progression-free interval (PFI), and overall survival (OS) were also assessed using KM survival curves and multivariate analysis in LGG. Meanwhile, the Gene Set Enrichment Analysis (GSEA) was also implemented to determine the potential effect of the SAT1 gene in LGG. Furthermore, the predictive power of SAT1 was validated using an independent LGG cohort from the Chinese Glioma Genome Atlas (CGGA) data. Results In general, the expression of SAT1 is different between most tumors and their adjacent normal tissues. The results demonstrated that SAT1 expression is positively associated with TMB in LGG, BRCA, and THYM. The results displayed that the expression level of SAT1 is obviously correlated with the level of infiltrating macrophages and CD8 + T cells, and the levels of most immune gene sets were associated with the SAT1 expression in LGG. Interestingly, univariate and multivariate models significantly indicated that the OS and PFI of patients with LGG with high SAT1 levels were poorer than those with low SAT1 expression in the TCGA LGG cohort. GSEA showed that SAT1 was involved in immune regulation and multiple signaling pathways. Finally, our analysis demonstrated that SAT1 was closely associated with IDH mutation, 1p19q codeletion, chemoradiotherapy resistance and disease recurrence. Conclusions Abundant expression of SAT1 was related to poor disease prognosis and abundant immune cell infiltration in LGG.

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Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy

Cited by 16 publications

References 56 publications

Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy

Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy

A Thoracic Outlet Syndrome That Concealed a Glioblastoma. Findings from a Case Report

Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma

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