Clinical diagnosis of Alzheimer's disease

Abstract

Article abstract-Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services *For Work Group Participants and Affiliations, see page 943.

Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community‐Dwelling Japanese Elderly: The Hisayama Study

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Diagnostic utility of ASL‐MRI and FDG‐PET in the behavioral variant of FTD and AD

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Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL‐VBM study

“…A total of 127 participants ( M age  = 78.26 years; SD age  = 7.33 years), including 47 with probable AD (McKhann et al ., 1984), 41 with probable DLB (McKeith et al ., 2005) and 39 similarly‐aged healthy controls, were recruited from a community‐dwelling population of patients referred to local Old Age Psychiatry, Geriatric Medicine or Neurology Services. Control participants were recruited from friends and spouses of patients and from a bank of volunteer participants held by the university and local clinical research network.…”