Clinical Diagnosis of Electrical Versus Anatomic Left Ventricular Hypertrophy

Carfilzomib‐associated cardiovascular adverse events in a non‐Caucasian cohort of patients with multiple myeloma: A real‐world experience

“…Though EKG is not sensitive enough to detect LVH, the specificity reaches 95% in clinical and autopsy studies and hence should provide a basis for a detailed cardiac evaluation. 7 Although minority populations are at high cardiovascular risk compared to Caucasian population, our results do not show any correlation between cardiovascular risk factors such as HTN, DM, smoking, history of coronary events, stroke, Source of Support: The authors did not receive any support in the form of grants, equipment, or drugs.…”

Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

“…15 QRS amplitude has been clinically used in the diagnosis of LV hypertrophy (LVH) but proved to have limited sensitivity in predicting LV hypertrophy, irrespective of the imaging technique used. 12,44 This is supported by the independent relevance of the two variables in predicting cardiovascular mortality in normals and hypertensive patients. 45 In the absence of fixed slow depolarization, eg bundle branch block, the depolarization wave length is determined by myocardial thickness which is known to have mid-thickness fibrosis that itself adds to the slow conduction, as shown experimentally.…”

“…QRS amplitude has been clinically used in the diagnosis of LV hypertrophy (LVH) but proved to have limited sensitivity in predicting LV hypertrophy, irrespective of the imaging technique used . This is supported by the independent relevance of the two variables in predicting cardiovascular mortality in normals and hypertensive patients …”

Einthoven and electrical risk: Value of the electrocardiogram to predict sudden cardiac death

“…However ECG‐LVH was independently associated with SCD risk even after adjustment for echo‐LVH . These findings suggest that increased myocardial voltage likely represents adverse “electrical” remodeling, conferring a risk that is distinct from the “anatomic” remodeling of echocardiographic LV hypertrophy . Delayed intrinsicoid deflection (DID) of the QRS complex is an ECG marker that contributes to risk of arrhythmogenesis independent of anatomic increase in LV mass .…”